Neurotoxicology: Approaches and Methods
Chang, Louis W.; Slikker, Jr., William
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Table of contents
- Contentsvii
- Contributorsxi
- Forewordxv
- Prefacexix
- Part I: Neuromorphological and Neuropathological Approaches1
- Chapter 1. Selected Histopathological and Histochemical Methods for Neurotoxicity Assessment5
- Chapter 2. Neuroanatomical Techniques for Labeling Neurons and Their Utility in Neurotoxicology27
- Chapter 3. Enzyme Histochemical Methods and Techniques67
- Chapter 4. Ultrastructural Methods for Neurotoxicology and Neuropathology81
- Chapter 5. Quantitative Morphometry for Neurotoxicity Assessment99
- Part II: Neurophysiological Approaches and Methods131
- Chapter 6. Electrophysiological Analysis of Ion Channel Function137
- Chapter 7. Electrophysiological Methods for Analysis of Effects of Neurotoxicants on Synaptic Transm157
- Chapter 8. Hippocampal Field Potentials: A Model System to Characterize Neurotoxicity183
- Chapter 9. Electrophysiological Analysis of Complex Brain Systems: Sensory Evoked Potentials and The205
- Part III: Neurobehavioral Toxicology223
- A. General Approaches231
- Chapter 10. Behavioral Screening Tests: Past, Present, and Future231
- Chapter 11. Neurobehavioral Methods for the Evaluation of Sensory Functions239
- Chapter 12. Motor Function and the Physical Properties of the Operant: Applications to Screening and265
- Chapter 13. Approaches to Utilizing Aspects of Cognitive Function as Indicators of Neurotoxicity301
- Chapter 14. Use of Drug Discrimination Learning in Behavioral Toxicology: Classification and Charact309
- Chapter 15. Extrapolating Scientific Data from Animals to Humans in Behavioral Toxicology and Behavi323
- B. Biochemical Correlates for Neurobehavioral Toxicity333
- Chapter 16. Role of Dopaminergic and Glutamatergic Neurotransmitter Systems in Lead-Induced Learning333
- Chapter 17. Dopaminergic Bases of Polychlorinated Biphenyl-Induced Neurotoxicity347
- Chapter 18. Bases of Excitatory Amino Acid System-Related Neurotoxicity359
- Chapter 19. Role of Serotonergic Systems in Behavioral Toxicity371
- Part IV: Neurochemical and Biomolecular Approaches381
- A. General and Selected Approaches385
- Chapter 20. Basic Biochemical Approaches in Neurotoxicology: Assessment of Neurotransmitters and Neu385
- Chapter 21. Biomolecular Approaches to Neurotoxic Hazard Assessment399
- Chapter 22. Nucleic Acid Hybridization Techniques and Neurotoxicity Assessment423
- Chapter 23. Application of the Technique of Brain Microdialysis in Determining the Mechanisms of Act433
- Chapter 24. Combined Electrical Resistance Method for Cell Volume Measurement and Continuous Perfusi439
- Chapter 25. Electron Probe X-Ray Microanalysis as a Tool for Discerning Mechanisms of Nerve Injury445
- B. Mechanism-Based Neurotoxicity Assessment455
- Chapter 26. Glutamate Receptor-Mediated Neurotoxicity455
- Chapter 27. Assessment of Neurotoxicity via Chemical Perturbation of Axonal Transport465
- Chapter 28. Disruption of Energy Metabolism and Mitochondrial Function483
- Part V: In Vitro Neurotoxicology491
- Chapter 29. Strategic Approaches to in Vitro Neurotoxicology495
- Chapter 30. The Use of Serum-Free Aggregating Brain Cell Cultures in Neurotoxicology507
- Chapter 31. Brain Slice Techniques in Neurotoxicology517
- Chapter 32. Cell Suspension Techniques in Neurotoxicology537
- Chapter 33. Central Nervous System Glial Cell Cultures for Neurotoxicological Investigations549
- Chapter 34. Neurotoxicology Studies Utilizing Schwann Cell-Neuronal Interactions in Vitro563
- Chapter 35. Organotypic Cultures of Mammalian Nerve Tissues: A Model System for Neurotoxicological:573
- Chapter 36. Human Neuronal Cell Lines as in Vitro Models581
- Chapter 37. In Vitro Systems for the Investigation of Calcium Homeostasis and Calcium-Induced Cell D595
- Chapter 38. In Vitro Electrophysiological Studies in Neurotoxicology603
- Part VI: Clinical Neurotoxicology613
- A. Principles and Issues617
- Chapter 39. Basic Principles of Clinical Neurotoxicology617
- Chapter 40. Clinical Neurotoxicology of Industrial and Agricultural Chemicals629
- Chapter 41. Clinical Neurotoxicological Concerns on Drugs of Abuse641
- Chapter 42. Clinical Neurotoxic Concerns on Antineoplastic Agents657
- Chapter 43. Neurotoxins and Neurodegenerative Diseases671
- B. Clinical Approaches to Neurotoxicology689
- Chapter 44. The Recognition and Differentiation of Neurotoxic and Nonneurotoxic Syndromes689
- Chapter 45. Exposure Assessment in Clinical Neurotoxicology: Environmental Monitoring And Biologic M695
- Chapter 46. Clinico-Neuropsychological Assessment Methods in Behavioral Neurotoxicology711
- Chapter 47. Behavioral Neurophysiology: Quantitative Measures of Sensory Toxicity727
- Chapter 48. Electrophysiological Investigations of Toxic Neuropathies737
- Chapter 49. Evoked Potential Testing in Clinical Neurotoxicology747
- Chapter 50. Neuroimaging in Neurotoxicology753
- Part VII: Risk Assessment for Neurotoxicty765
- Chapter 51. Concepts on Quantitative Risk Assessment of Neurotoxicants771
- Chapter 52. Quantitative Approaches to Risk Assessment in Neurotoxicology777
- Chapter 53. Use of Biological Markers in the Quantitative Assessment of Neurotoxic Risk789
- Chapter 54. Developmental Neurotoxicology Risk Assessment805
- Chapter 55. Unique Dimensions of Neurotoxic Risk Assessment815
- Index825
Book details
- Vendor Elsevier S & T
- SKU 9780121680558
- ISBN-13 9780080537474
- Author Chang, Louis W.; Slikker, Jr., William
- Category Medical
- Subject Reference
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Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market.
Key Features
* Discusses neurobehavioral testing methods for assessment of neural dysfunctions
* Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems
* Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity
* Presents step-by-step procedures for many methods
* Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation
Key Features
* Discusses neurobehavioral testing methods for assessment of neural dysfunctions
* Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems
* Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity
* Presents step-by-step procedures for many methods
* Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation
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