Elsevier S & T

NGF and Related Molecules in Health and Disease

Aloe, L.; Calza, L.

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Table of contents
  • NGF AND RELATED MOLECULES IN HEALTH AND DISEASEiii
  • Copyright Pageiv
  • Contentsxv
  • List of Contributorsv
  • Prefacexi
  • Acknowledgmentsxiii
  • Section I: Growth factors and cell signaling1
  • Chapter 1. Trafficking the NGF signal: implications for normal and degenerating neurons3
  • Chapter 2. The p75 neurotrophin receptor: multiple interactors and numerous functions25
  • Chapter 3. The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death s41
  • Chapter 4. The role of NT-3 signaling in Merkel cell development63
  • Section II: Growth factors, progenitor cells and cell survival73
  • Chapter 5. Stem cells and nervous tissue repair: from in vitro to in vivo75
  • Chapter 6. Pathways of survival induced by NGF and extracellular ATP after growth factor deprivation93
  • Chapter 7. ProNGF: a neurotrophic or an apoptotic molecule?101
  • Chapter 8. NGF deprivation-induced gene expression: after ten years, where do we stand?111
  • Chapter 9. Neural stem and progenitor cells: choosing the right Shc127
  • Section III: Neurotrophins and CNS135
  • Chapter 10. Acute and long-term synaptic modulation by neurotrophins137
  • Chapter 11. Neurotrophic factors and CNS disorders: findings in rodent models of depression and schi151
  • Chapter 12. Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative di167
  • Chapter 13. Neurobehavioral coping to altered gravity: endogenous responses of neurotrophins185
  • Chapter 14. Neurotrophic factors in Huntington’s disease195
  • Section IV: Neurotrophins, PNS and peripheral tissues231
  • Chapter 15. Neural crest development and neuroblastoma: the genetic and biological link233
  • Chapter 16. Neurotrophin-3 in the development of the enteric nervous system243
  • Chapter 17. Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance265
  • Chapter 18. Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role f279
  • Chapter 19. Neurotrophins in spinal cord nociceptive pathways291
  • Section V: Neurotrophins and the immune system323
  • Chapter 20. The role of neurotrophins in bronchial asthma: contribution of the pan-neurotrophin rece325
  • Chapter 21. Expression of nerve growth factor in the airways and its possible role in asthma335
  • Chapter 22. Neurotrophins and neurotrophin receptors in allergic asthma347
  • Chapter 23. Nerve growth factor and wound healing369
  • Section VI. Neurotrophins and neuro-inflammatory responses385
  • Chapter 24. Interactions between the cells of the immune and nervous system: neurotrophins387
  • Chapter 25. Role of nerve growth factor and other trophic factors in brain inflammation403
  • Chapter 26. Remyelination in multiple sclerosis: a new role for neurotrophins?415
  • Chapter 27. Role of NGF and neurogenic inflammation in the pathogenesis of psoriasis433
  • Section VII: Neurotrophic factors and potential therapeutic applications439
  • Chapter 28. Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene the441
  • Chapter 29. Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the inju451
  • Chapter 30. Neurotrophic factors and their receptors in human sensory neuropathies477
  • Chapter 31. Epithelial growth control by neurotrophins: leads and lessons from the hair follicle493
  • Chapter 32. Nerve growth factor, human skin ulcers and vascularization. Our experience515
  • Section VIII: Overview and conclusion523
  • Chapter 33. The nerve growth factor and the neuroscience chess board525
  • Index529
Book details
  • Vendor Elsevier S & T
  • SKU 9780444514721
  • ISBN-13 9780080497501
  • Author Aloe, L.; Calza, L.
  • Category Medical
  • Subject Neuroscience

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The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed.



Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Behçet's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy.