Nitric Oxide
Regular price
63.000 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Cover
- Nitric Oxideiii
- Copyright pageiv
- Information About the Society for Experimental Biology (SEB)v
- Information about the Series Editorsvii
- Professor Mike Thorndykevii
- Dr Rod Wilsonvii
- Information about the Volume Editorsix
- Professor Bruno Totaix
- Professor Barry Trimmerix
- Prefacexi
- List of Contributorsxiii
- Contentsxvii
- Chapter 1. On the comparative biology of Nitric Oxide (NO) synthetic pathways: Parallel evolution of1
- Introduction1
- Gaseous messengers in animals2
- The concept of NO signaling in animal physiology4
- NO in comparative and evolutionary contexts6
- Multiplicity of NO synthetic pathways8
- Abiotic reduction of nitrites results in nonenzymatic NO formation9
- Conditions for intracellular nonenzymatic NO formation: Neurons as models20
- Nonenzymatic NO formation: Nitrite photolysis21
- A brief overview of the diversity of conventional nitric oxide synthases23
- Nonconventional NOSs from plants and animals28
- Conclusions30
- References31
- Chapter 2. Nitric oxide biogenesis, signalling and roles in molluscs: The Sepia officinalis paradigm45
- Introduction45
- Molluscs46
- Conclusions and perspectives58
- References58
- Chapter 3. Soluble guanylyl cyclases in invertebrates: Targets for NO and O265
- Mammalian soluble guanylyl cyclases65
- Conventional invertebrate sGCs67
- Atypical sGCS70
- Behavioral studies indicating roles for atypical sGCs76
- Conclusion79
- Acknowledgements79
- References79
- Chapter 4. Nitric oxide signalling in insect epithelial transport83
- Nitric oxide synthase in D. melanogaster83
- NO modulates fluid transport85
- Interactions between NO and signalling components90
- Function of NO signalling in tubules: Fluid transport91
- Function of NO signalling in tubules: Immune function96
- Conclusions101
- Acknowledgements101
- References102
- Chapter 5. Nitric oxide/cyclic GMP signaling and insect behavior107
- NO in insect nervous systems107
- Components of NO signaling in insect nervous systems: NOS, NO, sGC, cGMP108
- Contribution of NO signaling to insect behavior111
- NO function in sensory neuropils111
- Central nervous mechanisms115
- The effector level118
- Summary120
- References121
- Chapter 6. Impact of nitrative/nitrosative stress in mitochondria: Unraveling targets for malaria ch129
- Introduction: Exposure of cells to nitrogen oxides129
- Protein nitration and S-nitrosation in mitochondria130
- Nitrative and nitrosative stress in a complex biological system: Malaria infection137
- Acknowledgements142
- References142
- Chapter 7. Effects of S-nitrosation of nitric oxide synthase151
- NOS enzymology and physiology151
- Regulation of NOS154
- Zinc tetrathiolate cluster and reactivity toward NO155
- S-nitrosation, also known as S-nitrosylation157
- Gaps in our current understanding of S-nitrosation158
- The specificity of S-nitrosation161
- S-nitrosation of eNOS162
- S-nitrosation of iNOS166
- S-nitrosation of nNOS168
- Implications and conclusions169
- Acknowledgments170
- References170
- Chapter 8. Regulatory role and evolution of unconventional NOS-related RNAs181
- Introduction181
- NOS mRNA in Lymnaea: Organisation and paradoxical expression183
- Paradoxical expression explained by an unconventional RNA produced from NOS pseudogene?186
- Reward conditioning regulates NOS gene and NOS pseudogene expression187
- Evolution of unconventional regulatory NOS-related RNAs188
- Other NOS-related transcripts in Lymnaea192
- From molluscs to mammals194
- Conclusions194
- References195
- Chapter 9. The role of blood nitrite in the control of hypoxic vasodilation199
- Introduction199
- The discovery of nitrite as a vasodilator201
- The reactions of nitrite with Hb202
- Transport of nitrite into RBCs203
- Nitrite reduction by hemoglobin204
- Escape of NO from RBCs205
- Induction of vasodilation207
- Conclusions and perspectives209
- Acknowledgments209
- References209
- Chapter 10. Nitrite is a vascular store of NO which mediates hypoxic signaling and protects against213
- Introduction213
- Nitrite is a vasodilator under normal physiological conditions and during hypoxic or exercise stress215
- Hemoglobin is a nitrite reductase215
- Hemoglobin-mediated nitrite reduction is regulated by oxygen and pH217
- Nitrite protects against ischemia/reperfusion (I/R) injury218
- Potential mechanisms of nitrite-mediated cytoprotection219
- S-nitrosation, caspases and apoptosis219
- Reactive oxygen species (ROS) and cellular injury221
- The role of guanylyl cyclase (GC) and mitochondrial KATP channels221
- Activation of cAMP-dependent pathways and cardiac contractility222
- Inflammation223
- Conclusions223
- Disclosure223
- References223
- Chapter 11. Nitric oxide and the zebrafish (Danio rerio): Developmental neurobiology and brain neuro229
- Introduction229
- Identities of NOS isoforms233
- NOS I ontogeny241
- NOS I and adult neurogenesis254
- Conclusions261
- Acknowledgements265
- References265
- Chapter 12. NO in the development of fish275
- Introduction275
- Nitric oxide synthases in fish276
- Expression of NOS during early development279
- NO and vascular reactivity280
- The influence of NO on cardiac activity in early stages283
- NO and tissue vascularization during development284
- NO in the developing enteric system286
- NO in the gill cells and opercular tissue287
- Acknowledgements288
- References288
- Color Plate SectionColour Pl
- Chapter 13. Role of nitric oxide in vascular regulation in fish293
- Introduction293
- Nitric oxide and the fish vascular system298
- NOS localization in fish circulation298
- Effects of NO on fish vasculature301
- Conclusions303
- References303
- Chapter 14. NOS distribution and NO control of cardiac performance in fish and amphibian hearts311
- Introduction311
- Basic functional morphology of the fish and amphibian hearts313
- NOS distribution in cardiac tissues315
- NO modulation of cardiac function in teleost and frog hearts318
- Teleosts319
- Frogs325
- Conclusions and perspectives332
- References332
- Chapter 15. Nitric oxide and histamine in hibernation and neuroprotection339
- Introduction339
- NO synthesis and localization in the CNS342
- Neurobiological role of NO344
- The histaminergic system and its roles in the brain348
- Histamine, hibernation, and neuroprotection351
- Concluding remarks356
- References358
- Chapter 16. Nitric oxide, peroxynitrite and matrix metalloproteinases: Insight into the pathogenesis367
- Defining sepsis367
- Initiation of sepsis369
- Manifestations of sepsis372
- Mechanisms of pathogenicity375
- MMPs and sepsis384
- Conclusions385
- Acknowledgements386
- References386
- Index of authors397
- Subject index447
This volume provides a novel insight to the evolutionary and comparative aspects of nitric oxide- nitric oxide synthase system as a central regulator of invertebrate and vertebrate homeostasis. By critically selecting and summarizing the ever–increasing number of original studies, these presentations review a variety of important signalling and modulatory roles played by nitric oxide at molecular, cell, organ and organ system levels. It addresses not only specialists and graduate students in the field, but also all biologists concerned with how this unique, gaseous, pleiotropic molecule has been employed by living systems, uncovering a new dimension of the wonders of life.