Nitric Oxide: Biology and Pathobiology
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Table of contents
- Copyright Pageiv
- Contentsvii
- Contributorsxi
- Prefacexvii
- Section I: Overview of Basic Principles1
- Chapter 1. Introduction and Overview3
- Section II: Principles of Biology21
- Chapter 2. The Chemical Properties of Nitric Oxide and Related Nitrogen Oxides23
- Chapter 3. The Chemical Biology of Nitric Oxide41
- Chapter 4. The Biological Chemistry of Peroxynitrite57
- Chapter 5. A Comparison of the Biological Reactivity of Nitric Oxide and Peroxynitrite83
- Chapter 6. Structural Variations to Accommodate Functional Themes of the Isoforms of NO Synthases91
- Chapter 7. Regulation of the Expression of Nitric Oxide Synthase Isoforms105
- Chapter 8. Molecular Regulation of Inducible Nitric Oxide Synthase129
- Chapter 9. Molecular Control of Endothelial Derived Nitric Oxide. A New Paradigm for Endothelial NOS157
- Chapter 10. Tetrahydrobiopterin: An Essential Cofactor of Nitric Oxide Synthase with an Elusive Role167
- Chapter 11. Regulation of Arginine Availability and Its Impact on NO Synthesis187
- Chapter 12. Relationship between Arginase Activity and Nitric Oxide Production199
- Chapter 13. The Physical Properties of Nitric Oxide: Determinants of the Dynamics of NO in Tissue209
- Chapter 14. Membrane Transport of Arginine and Cationic Amino Acid Analogs225
- Chapter 15. The Respiratory Cycle: A Three-Gas System243
- Chapter 16. Role for Nitric Oxide and Other Radicals in Signal Transduction251
- Chapter 17. Antioxidant Actions of Nitric Oxide265
- Chapter 18. Mechanisms through Which Reactive Nitrogen and Oxygen Species Interact with Physiologica277
- Chapter 19. Nitric Oxide, Oxygen Radicals, and Iron Metabolism293
- Chapter 20. Redox Modulation of Iron Regulatory Proteins by Nitric Oxide and Peroxynitrite315
- Chapter 21. Nitric Oxide, Oxidative Stress, and Signal Transduction329
- Chapter 22. Mechanisms of Antioxidant Defense against Nitric Oxide/Peroxynitrite343
- Chapter 23. Regulation of Oxygen Metabolism by Nitric Oxide355
- Chapter 24. Structure–Function Relationships in NO-Sensitive Guanylyl Cyclase369
- Chapter 25. Mechanism of Activation of Soluble Guanylyl Cyclase by NO: Allosteric Regulation through381
- Chapter 26. Cyclic GMP-Mediated Signaling Mechanisms in Smooth Muscle401
- Section III: Principles of Pathobiology427
- Chapter 27. Influence of Nitric Oxide on Neuroendocrine Function and Behavior429
- Chapter 28. Nitric Oxide and Cerebral Ischemia439
- Chapter 29. Role of Nitric Oxide in Neuronal Protection versus Apoptosis453
- Chapter 30. Nitric Oxide and Autoimmune Disease in the Nervous System: Pathobiology of Inflammation465
- Chapter 31. Role of Nitric Oxide in the Regulation of Blood Flow483
- Chapter 32. Nitric Oxide Synthase Gene Transfer503
- Chapter 33. Functional Influence of Gene Transfer of Recombinant Nitric Oxide Synthase to Cardiovasc525
- Chapter 34. Nitric Oxide and Vascular Endothelial Dysfunction547
- Chapter 35. Endothelium-Derived Hyperpolarizing Factor and Its Interaction with NO569
- Chapter 36. Role of Nitric Oxide in Myocardial Function585
- Chapter 37. Role of Nitric Oxide in the Microcirculation609
- Chapter 38. Activation of NOS by Ca2+-Dependent and Ca2+-Independent Mechanisms621
- Chapter 39. Role of Nitric Oxide in Ischemia–Reperfusion Injury633
- Chapter 40. Nitric Oxide: A Critical Determinant in Ischemia–Reperfusion649
- Chapter 41. Role of Nitric Oxide in Myocardial Ischemia–Reperfusion Injury661
- Chapter 42. Use of Mutant Mice to Elucidate Neuroprotective and Neurotoxic Actions of Nitric Oxide i687
- Chapter 43. Neurotoxic Actions and Mechanisms of Nitric Oxide695
- Chapter 44. Role of Macrophage-Derived Nitric Oxide in Target Cell Injury711
- Chapter 45. Physiological and Pathophysiological Roles of Nitric Oxide in Gastrointestinal Function725
- Chapter 46. Pathophysiological Effects of High-Output Production of Nitric Oxide733
- Chapter 47. Nitric Oxide and Septic Shock747
- Chapter 48. Nitric Oxide and Vascular Disease759
- Chapter 49. Cytotoxic Role of Nitric Oxide in Diabetes785
- Chapter 50. Role of Inducible Nitric Oxide Synthase in Autoimmune or Other Immune-Mediated Diseases811
- Chapter 51. Nitric Oxide and Platelet Function823
- Chapter 52. Pathophysiological Roles of Nitric Oxide in Inflammation841
- Chapter 53. Nitric Oxide, Chronic Joint Inflammation, and Pain873
- Chapter 54. Nitric Oxide and Cancer895
- Chapter 55. Vascular Nitric Oxide in Health and Disease921
- Chapter 56. Clinical Therapy with Inhaled Nitric Oxide in Respiratory Diseases931
- Chapter 57. Airborne Nitric Oxide in Health and Disease947
- Chapter 58. Nitric Oxide and Persistent Pulmonary Hypertension in the Newborn963
- Index983
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems.
NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells.
NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis.
This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications.
Key Features
* Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide
* Authored by world experts on nitric oxide
* Includes an overview of basic principles of biology and chemical biology
* Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense
NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells.
NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis.
This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications.
Key Features
* Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide
* Authored by world experts on nitric oxide
* Includes an overview of basic principles of biology and chemical biology
* Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense