Elsevier S & T

Nitric Oxide: Principles and Actions

Lancaster, Jr., Jack

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Table of contents
  • Cover
  • Contentsvii
  • Contributorsxiii
  • Prefacexv
  • Chapter 1. The Physiological and Pathological Chemistry of Nitric Oxide1
  • I. Introduction1
  • II. Why Is the Half-Life of Nitric Oxide So Short in Vivo10
  • III. Chemistry of Nitric Oxide and Related Nitrogen Oxides18
  • IV. Handling and Detection of Nitric Oxide32
  • V. Chemistry of Nitric Oxide Reacting with Superoxide39
  • VI. Conclusions69
  • References71
  • Chapter 2. Nitric Oxide Complexes of Metalloproteins: An Introductory Overview83
  • I. Introduction83
  • II. Nitric Oxide as a Paramagnetic Ligand84
  • III. Iron Model Complexes86
  • IV. Nitric Oxide Complexes of Ferrohemes in Proteins88
  • V. Nitric Oxide Complexes of Iron–Sulfur Proteins91
  • VI. Nitric Oxide Complexes of Other Nonheme Iron Proteins95
  • VII. Copper Complexes97
  • VIII. Conclusion98
  • IX. Appendix: Electron Paramagnetic Resonance99
  • References107
  • Chapter 3. Nitric Oxide as a Communication Signal in Vascular and Neuronal Cells111
  • I. Introduction111
  • II. Evidence That EDRF Is Nitric Oxide or a Labile Nitroso Precursor113
  • IV. Unique Chemical Properties for a Ubiquitous and General Physiological Mediator119
  • V. Signal Transduction Mechanisms for Transcellular Communication120
  • VI. Nitric Oxide as a Neuronal Messenger124
  • VII. Conclusions129
  • References130
  • Chapter 4. The Intracellular Reactions of Nitric Oxide in the Immune System and Its Enzymatic Synthe139
  • I. Introduction139
  • II. Intracellular Reactions of Nitric Oxide in the Immune System140
  • III. Enzymology of Nitric Oxide Synthesis148
  • References164
  • Chapter 5. The Role of Nitric Oxide in Autoimmune Diabetes177
  • I. Introduction177
  • II. Effects of Cytokines on β-Cell Function181
  • III. What Mediates Interleukin 1-Induced Islet Dysfunction?185
  • IV. Mechanism of Nitric Oxide Mediated Islet Dysfunction and Destruction187
  • V. Cellular Source of Interleukin 1-Induced Nitric Oxide Formation by Islets of Langerhans191
  • VI. Signaling Mechanism of Interleukin 1-Induced Expression of Nitric Oxide Synthase195
  • VII. Constitutive Nitric Oxide Synthase and Insulin Secretion196
  • VIII. Effects of Activated Macrophages on Islet Function198
  • IX. Proposed Mechanism by Which Interleukin 1 Induces β-Cell Dysfunction and Destruction198
  • X. Animal Models of Insulin-Dependent Diabetes Mellitus200
  • XI. Nitric Oxide and Islet Inflammation201
  • XII. Nitric Oxide Production by Human Islets202
  • XIII. Interventions204
  • XIV. Conclusions206
  • References207
  • Chapter 6. A Role for Nitric Oxide in Liver Inflammation and Infection219
  • I. Introduction219
  • II. Nitric Oxide and the Liver in Sepsis and Inflammation221
  • III. The Biochemistry of Hepatocyte Nitric Oxide Synthesis225
  • IV. Studies on in Vitro Actions of Nitric Oxide in Liver Cells227
  • V. Studies on in Vivo Actions of Nitric Oxide in the Liver231
  • VI. Summary233
  • References233
  • Chapter 7. Role of Nitric Oxide in Allograft Rejection237
  • I. Introduction237
  • II. Nitric Oxide Production in Rat Splenocyte Mixed Lymphocyte Reaction238
  • III. In Vitro Nitric Oxide Synthesis by Cells Recovered from Rat Sponge Matrix Allografts239
  • IV. In Vivo Nitric Oxide Synthesis during Allograft Rejection244
  • V. Effect of Nitric Oxide Synthesis in Defined Macrophage–Lymphocyte Cocultures245
  • VI. Effect of Authentic Nitric Oxide on Lymphocyte Function246
  • VII. Possible Mechanisms of Nitric Oxide-Induced Inhibition of Lymphocyte Activation248
  • VIII. Conclusion252
  • References253
  • Chapter 8. Role of Nitric Oxide in Treatment of Foods259
  • I. Introduction259
  • II. Historical Use of Nitrate and Nitrite in Cured Meats260
  • III. Nitric Oxide in Meat Curing: An Overview261
  • IV. Nitric Oxide and Cured Meat Color261
  • V. Nitric Oxide as an Antioxidant in Cured Meats266
  • VI. Nitrite and Nitric Oxide as Antimicrobial Agents269
  • VII. Direct Application of Nitric Oxide to Meats277
  • VIII. Nitrite, Nitric Oxide, and Nitrosamine Formation278
  • IX. Nitrate Prevention of "Late Gas" Defect in Cheese279
  • X. Nitric Oxide in Swollen Cans of Green Beans and Spinach279
  • XI. Summary279
  • References280
  • Chapter 9. The Enzymology and Occurrence of Nitric Oxide in the Biological Nitrogen Cycle289
  • I. Global Nitrogen Cycle289
  • II. Denitrifying Bacteria292
  • III. Evidence For and Against Nitric Oxide as an Intermediate in Denitrification Pathway297
  • IV. Nitric Oxide Reductase, Nitric Oxide-Consuming Enzyme of Denitrification Pathway307
  • V. Dissimilatory Nitrite Reductases, Enzymes That Generate Nitric Oxide in Denitrifying Bacteria312
  • VI. Genome for Denitrification320
  • VII. Nitric Oxide-Reducing Nitrite Reductases321
  • VIII. Denitrification by Chemolithotrophic Ammonia Oxidizers321
  • IX. Denitrification by Eukaryotic Microorganisms323
  • X. Nitric Oxide Production from Nitrite by Enteric and Related Bacteria324
  • XI. Nitric Oxide Production by Heterotrophic Nitrifiers326
  • XII. Toxicity of Nitric Oxide toward Bacteria, a Topic Joining Bacteria with the Nitric Oxide Syntha328
  • References329
  • Index345
Book details
  • Vendor Elsevier S & T
  • SKU 9780124355552
  • ISBN-13 9780080537542
  • Author Lancaster, Jr., Jack
  • Category Medical
  • Subject Biochemistry

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Description eBook delivery & access Reviews
This unique sourcebook serves as a comprehensive reference, bridging the well-established chemistry of nitric oxide and the new and exciting role of nitric oxide as an effector and signaling molecule in numerous biological systems. Nitric Oxide: Principles and Actions relates the chemical properties of the molecule to its possible effects on biological systems, under both normal physiological and pathophysiological conditions. Combining the chemistry and analysis of nitric oxide with newer studies of the relevance of the molecule gives this book a long life, making it extremely useful to researchers in a number of areas.

Key Features
* Provides a much needed compilation of what is known about nitric oxide and its properties
* Enables researchers to understand the importance and use of nitric oxide in systems of study
* Covers an area of tremendous growth in research
* Provides the first collection of the roles of nitric oxide in microbial and mammalian systems and as a probe of metalloenzymes
* Presents the historically important role of nitric oxide in food preservation