Nuclear Receptor Coregulators
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Table of contents
- Cover
- Contentsvii
- Contributorsxiii
- Prefacexv
- Chapter 1. Gene Silencing by Nuclear Orphan Receptors1
- I. Introduction2
- II. COUP-TFI, II (EAR3, ARP-1), and EAR2: Inhibitors of Diverse Genes by Multiple Mechanisms7
- III. DAX-1: Silencing in the Control of Steroidogenic and Sex-Determining Target Genes14
- IV. GCNF: Negative Control during Gametogenesis and Embryonic Development20
- V. SHP: Generic Heterodimeric Partner-Inhibiting Multiple Nuclear Receptor Pathways24
- VI. TR4 and TR2: Testicular Receptor with Homologous but Not Redundant Functions30
- VII. Conclusions34
- References35
- Chapter 2. Structure and Function of the Glucocorticoid Receptor Ligand Binding Domain49
- I. Functional Significance of the GR51
- II. Expression, Purification, and Characterization of the GR LBD55
- III. Fold of the Nuclear Receptor LBD and Specific Features of GR59
- IV. Ligand Recognition by GR64
- V. Modes of Ligand Recognition by GR Compared to Other Oxosteroid Receptors68
- VI. Characteristics of Cofactor Association with the GR LBD71
- VII. Role of the GR LBD in Chaperone Protein Association and Receptor Dimerization74
- VIII. Mutations in the GR LBD and Their Functional Consequences76
- IX. Progress Toward a Selective GR Modulator82
- X. Conclusions and Directions of Future Research83
- References84
- Chapter 3. Nuclear Receptor Recruitment of Histone-Modifying Enzymes to Target Gene Promoters93
- I. Overview of Nuclear Receptors94
- II. Chromatin Structure96
- III. Histone Modifications in Regulated Transcription98
- IV. NR Coactivators with Histone-Modifying Activity103
- V. NR Corepressors with Histone-Modifying Activity109
- VI. Conclusion114
- References115
- Chapter 4. Corepressor Recruitment by Agonist-Bound Nuclear Receptors123
- I. The Nuclear Receptor Superfamily124
- II. Coregulatory Proteins in Hormone-Dependent Regulation of Transcription127
- III. Histone Deacetylases in Regulation of Gene Expression132
- IV. LCoR and RIP140 Recruit the Corepressor C-Terminal Binding Protein (CTBP)135
- V. Potential Roles of LCoR and RIP140 in Hormone-Dependent Receptor Function136
- VI. Concluding Remarks137
- References138
- Chapter 5. Pharmacology of Nuclear Receptor„Coregulator Recognition145
- I. Introduction146
- II. Coregulators Involved in Nuclear Receptor Action150
- III. Nuclear Receptor„Coregulator Recognition164
- IV. Pharmacology of Nuclear Receptor„Coregulator Recognition170
- V. Conclusion173
- References174
- Chapter 6. Thyroid Hormone Receptor Subtypes and their Interaction with Steroid Receptor Coactivator185
- I. Introduction186
- II. Physiology of TR Function190
- III. Physiology of SRC Function (SRC-1, SRC-2, and SRC-3)194
- IV. Interaction of TRs and SRC in the Pituitary196
- V. SRC-1 and TRs in Peripheral Tissues200
- VI. Conclusions202
- References203
- Chapter 7. Corepressor Requirement and Thyroid Hormone Receptor Function During Xenopus Development209
- I. Introduction210
- II. Mechanism of TR Action212
- III. Dual Role of TRs During Amphibian Development216
- IV. Corepressor Function During Amphibian Development219
- V. Conclusion and Perspectives225
- References226
- Chapter 8. Cdc25B as a Steroid Receptor Coactivator231
- I. Introduction233
- II. The Cdc25 Family of Proteins234
- III. Evaluation of the Cdc25B Role in Murine Mammary Glands236
- IV. Cdc25B. A Coactivator that Enhances Steroid Receptor-Dependent Transcription239
- V. Coactivator Function of Cdc25B in the Prostate245
- VI. Conclusions248
- References252
- Chapter 9. Vitamin D Receptor„DNA Interactions257
- I. Introduction258
- II. VDR–DR3 Binding261
- III. Alternative Response Elements266
- IV. RXR–VDR Formation269
- V. Conclusions270
- References271
- Index275
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
*First published in 1943, Vitamins and Hormones is AP's longest running serial
*Each volume contains cutting edge reviews by leading contributors
*First published in 1943, Vitamins and Hormones is AP's longest running serial
*Each volume contains cutting edge reviews by leading contributors