Elsevier S & T

Nuclear Receptors

Russell, David W.

In stock

No reviews

74.000 KD inc. VAT

License

perpetual

Table of contents

Table of Contentsv
Contributor to Volume 364ix
Prefacexiii
Volumes in Seriesxv
Section I: Analysis of Nuclear Receptor Ligands1
Chapter 1. Identification of Novel Nuclear Hormone Receptor Ligands by Activity-Guided Purification3
Chapter 2. Quantitation of Receptor Ligands by Mass Spectrometry24
Chapter 3. Site-Specific Fluorescent Labeling of Estrogen Receptors and Structure–Activity Relatio37
Chapter 4. Cell-Free Ligand Binding Assays for Nuclear Receptors53
Chapter 5. Design and Synthesis of Receptor Ligands71
Section II: Structure/Function Analysis of Nuclear Receptors93
Chapter 6. Bioinformatics of Nuclear Receptors95
Chapter 7. Application of Random Peptide Phage Display to the Study of Nuclear Hormone Receptors118
Chapter 8. Methods for Detecting Domain Interactions in Nuclear Receptors142
Chapter 9. The Orphan Receptor SHP and the Three-Hybrid Interference Assay152
Chapter 10. Regulation of Glucocorticoid Receptor Ligand- Binding Activity by the hsp90/hsp70-based159
Chapter 11. Analysis of Receptor Phosphorylation173
Section III: Analysis of Nuclear Receptor Cofactors and Chromatin Remodeling203
Chapter 12. Acetylation and Methylation in Nuclear Receptor Gene Activation205
Chapter 13. Steroid Receptor Coactivator Peptidomimetics223
Chapter 14. Biochemical Isolation and Analysis of a Nuclear Receptor Corepressor Complex246
Chapter 15. Isolation and Functional Characterization of the TRAP/Mediator Complex257
Chapter 16. Study of Nuclear Receptor-Induced Transcription Complex Assembly and Histone Modificatio284
Section IV: Identification of Nuclear Receptor Target Genes and Effectors297
Chapter 17. Serial Analysis of Gene Expression and Gene Trapping to Identify Nuclear Receptor Target299
Chapter 18. Expression Cloning of Receptor Ligand Transporters322
Chapter 19. Nuclear Receptor Target Gene Discovery Using High-Throughput Chromatin Immunoprecipitati339
Chapter 20. RNA Gel Shift Assays for Analysis of Hormone Control of mRNA Stability350
Chapter 21. Expression Cloning of Ligand Biosynthetic Enzymes361
Section V: Use of Animal Models to Study Nuclear Receptor Function377
Chapter 22. Targeted Conditional Somatic Mutagenesis in the Mouse: Temporally-Controlled Knock Out o379
Chapter 23. Analysis of Small Molecule Metabolism in Zebrafish408
Chapter 24. Analysis of Nuclear Receptor Function in the Mouse Auditory System426
Chapter 25. Analysis of Estrogen Receptor Expression in Tissues448
Chapter 26. In Vivo and In Vitro Reporter Systems for Studying Nuclear Receptor and Ligand Activitie463
Chapter 27. Methods to Characterize Drosophila Nuclear Receptor Activation and Function In Vivo475
Author Index491
Subject Index525
Color Plates SectionColor Plete-1

Book details

Vendor Elsevier S & T
SKU 9780121822675
ISBN-13 9780080497075
Author Russell, David W.
Category Science
Subject Biochemistry

Do you have questions about this book?

Ask an expert!

Nuclear Receptors are inducible transcription factors that mediate complex effects on development, differentiation and homeostasis. They regulate the transcription of their target genes through binding to DNA sequences.

*Analysis of Nuclear Receptor Ligands
*Structure/Function Analysis of Nuclear Receptors
*Analysis of Nuclear Receptor Co-Factors and Chromatin Remodeling

Instant delivery by email
Your access email arrives within minutes of checkout, with a sign-in link for each book — no shipping, no waiting.

Read on any device
Books open in VitalSource Bookshelf on your phone, tablet, or computer, online or offline. Your library is always available at aafaq.vitalsource.com — just log in with the email you used at checkout.

Lost the email?
Resend it to yourself in seconds from My eBook orders, or email cs@aafaqeducation.com and we'll help.