Optical Biosensors: Today and Tomorrow
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Table of contents
- Cover
- Table of Contentsvii
- Prefaceix
- List of Contributorsxi
- PART I OPTICAL BIOSENSORS: TODAY1
- Chapter 1 Optrode-based fiber optic biosensors (bio-optrode)3
- 1.1. Principle of operation4
- 1.2. History34
- 1.3. State of the art for bio-optrodes35
- 1.4. Advantages and limitations of bio-optrode technology65
- 1.5. Potential for improving performance or expanding current capabilities66
- References73
- Chapter 2 Evanescent wave fiber optic biosensors83
- 2.1. Technical concept83
- 2.2. History106
- 2.3. State of the art107
- 2.4. Advantages and limitations125
- 2.5. Future of evanescent fiber optic biosensors129
- Acknowledgements132
- References132
- Chapter 3 Planar waveguides for fluorescence biosensors139
- 3.1. Technical concept140
- 3.2. History154
- 3.3. State of the art158
- 3.4. Advantages and limitations for use in optical biosensing169
- 3.5. Potential for improving performance or expanding current capabilities170
- Acknowledgements176
- References176
- Chapter 4 Surface plasmon resonance biosensors185
- 4.1. Technical concept185
- 4.2. History210
- 4.3. State of the art211
- 4.4. Advantages and limitations of SPR biosensors233
- 4.5. Potential for expanding current capabilities235
- References237
- Chapter 5 Flow immunosensors243
- 5.1. Principles of operation244
- 5.2. History of the displacement immunosensor249
- 5.3. Applications/implementation of the displacement immunosensor257
- 5.4. History of the kinetic exclusion sensor264
- 5.5. Advantages and limitations274
- 5.6. Future potential278
- Acknowledgments281
- References281
- Chapter 6 Fluorescence lifetime biosensing: Entering the mainstream287
- 6.1. Technical concept287
- 6.2. History298
- 6.3. State of the art302
- 6.4. Advantages and limitations for use in optical biosensing308
- 6.5. Potential for improving performance or expanding current capabilities311
- References314
- Chapter 7 Electrochemiluminescence317
- 7.1. Principles of operation317
- 7.2. History331
- 7.3. State of the art340
- 7.4. Advantages and limitations354
- 7.5. Potential for expanding current capabilities355
- References370
- Chapter 8 Plasmonic SERS molecular sentinels: A new biosensing approach385
- 8.1. Technical concept386
- 8.2. History389
- 8.3. State of the art393
- 8.4. Advantages and limitations for use in optical biosensing395
- 8.5. Potential for improving performance or expanding current capabilities396
- Acknowledgments398
- References398
- PART II OPTICAL BIOSENSORS: TOMORROW401
- Chapter 9 Cavity ring-down biosensing403
- 9.1. Technical concept403
- 9.2. History410
- 9.3. State of the art413
- 9.4. Potential for improving performance or expanding current capabilities416
- References417
- Chapter 10 Cantilever biosensors419
- 10.1. Technical concept419
- 10.2. History433
- 10.3. State of the art434
- 10.4. Advantages and limitations for use in optical biosensing446
- 10.5. Potential for improving performance or expanding current capabilities448
- Acknowledgements449
- References449
- Chapter 11 Protein microarray technologies: An array of applications453
- 11.1. Technical concept454
- 11.2. Historical background459
- 11.3. Applications for protein microarrays460
- 11.4. Advantages and limitations of protein microarrays464
- References465
- Chapter 12 Single-domain antibodies: Rugged recognition elements for tomorrow’s biosensors469
- 12.1. Technical concept470
- 12.2. History472
- 12.3. State of the art479
- 12.4. Advantages and limitations for use in optical biosensing487
- 12.5. Potential for improving performance or expanding current capabilities488
- Acknowledgements489
- References489
- Chapter 13 Nucleic acids for reagentless biosensors493
- 13.1. The concept of a reagentless biosensor494
- 13.2. History – in vitro selection495
- 13.3. State of the art501
- 13.4. Advantages and limitations525
- 13.5. Potential for improving performance527
- References535
- Chapter 14 Imprinted polymers and their application in optical sensors543
- 14.1. Molecular imprinting: technical concepts544
- 14.2. Development of MIP-based optical sensors: history and state of the art560
- 14.3. Market potential of MIP sensors and future prospects574
- 14.4. New developments575
- References577
- Chapter 15 Nanoparticles for biosensors583
- 15.1. Technical concepts584
- 15.2. State of the art592
- 15.3. Advantages and disadvantages612
- 15.4. Future perspectives614
- References616
- Chapter 16 Fluorescence-based intracellular sensing623
- 16.1. Technical concepts623
- 16.2. History629
- 16.3. State of the art634
- 16.4. Advantages and limitations for use in optical biosensing647
- 16.5. Potential for improving performance or expanding current capabilities649
- Acknowledgements652
- References652
- Chapter 17 Microfluidics659
- 17.1. Technical concept659
- 17.2. History664
- 17.3. State of the art665
- 17.4. Advantages and limitations for use in optical biosensing677
- 17.5. Potential for improving performance or expanding current capabilities678
- References679
- Index683
- Color Plates689
Optical Biosensors, 2ed describes the principles of successful systems, examples of applications, and evaluates the advantages and deficiencies of each. It also addresses future developments on two levels: possible improvements in existing systems and emerging technologies that could provide new capabilities in the future. The book is formatted for ease of use and is therefore suitable for scientists and engineers, students and researcher at all levels in the field.
* Comprehensive analysis and review of the underlying principles by optical biosensors
* Updates and informs on all the latest developments and hot topic areas
* Evaluates current methods showing the advantages and disadvantages of various systems involved
* Comprehensive analysis and review of the underlying principles by optical biosensors
* Updates and informs on all the latest developments and hot topic areas
* Evaluates current methods showing the advantages and disadvantages of various systems involved