Elsevier S & T

Oxygen Sensing

Semenza, Gregg L.

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Table of contents
  • Table of Contentsv
  • Contributors to Volume 381xi
  • Prefacexix
  • Volumes in Seriesxxi
  • Section I: Lung and the Airways1
  • Chapter 1. Assessment of Oxygen Sensing by Model Airway and Arterial Chemoreceptors3
  • Chapter 2. Methods to Study Neuroepithelial Bodies as Airway Oxygen Sensors26
  • Chapter 3. Role of Glutathione Redox State in Oxygen Sensing by Carotid Body Chemoreceptor Cells40
  • Chapter 4. Determination of Signaling Pathways Responsible for Hypoxic Pulmonary Vasoconstriction: U71
  • Chapter 5. Oxygen-Dependent Regulation of Pulmonary Circulation87
  • Chapter 6. Detection of Oxygen Sensing During Intermittent Hypoxia107
  • Chapter 7. Functional Analysis of the Role of Hypoxia-Inducible Factor 1 in the Pathogenesis of Hypo121
  • Section II: Cardiovascular and Blood231
  • Chapter 8. Perceived Hyperoxia: Oxygen-Regulated Signal Transduction Pathways in the Heart
  • Chapter 9. Evaluation of Cytochrome P450-4A w-Hydroxylase and 20-Hydroxyeicosatetraenoic Acid as an
  • Chapter 10. Assessment of Roles for Oxidant Mechanisms in Vascular Oxygen Sensing
  • Chapter 11. Survival Surgery for Coronary Occlusion and Reoxygenation in a Rodent Model
  • Chapter 12. Measurement of In Vivo Oxidative Stress Regulated by the Rac1 GTPase
  • Chapter 13. Proteomic Analysis of the Mammalian Cell Nucleus
  • Chapter 14. Oxygen-Dependent Regulation of Erythropoiesis
  • Chapter 15. Physiologic Responses to Chronic Anemia in Fetal Sheep
  • Chapter 16. Hypoxia-Inducible Factor 1 a-Deficient Chimeric Mice as a Model to Study Abnormal B Lymp
  • Section III: Ion Channels231
  • Chapter 17. Molecular Strategies for Studying Oxygen- Sensitive Kþ Channels233
  • Chapter 18. Oxygen Sensing by Human Recombinant K+* Channels: Assessment of the Use of Stable Cell L257
  • Chapter 19. Methods to Study Oxygen Sensing Sodium Channels275
  • Chapter 20. Analysis of Oxygen-Sensitive Human Cardiac L-Type Ca2+ Channel a1C Subunit (hHT Isoform)290
  • Section IV: Tumor Biology303
  • Chapter 21. Analysis of von Hippel–Lindau Tumor Suppressor as a Mediator of Cellular Oxygen Sensin305
  • Chapter 22. Analysis of von Hippel–Lindau Hereditary Cancer Syndrome: Implications of Oxygen Sensi320
  • Chapter 23. Tumor Hypoxia and Malignant Progression335
  • Section V: Metabolism355
  • Chapter 24. Oxygen-Dependent Regulation of Hepatic Glucose Metabolism357
  • Chapter 25. Assessing Oxygen Sensitivity of the Multidrug Resistance (MDR) Gene376
  • Chapter 26. Oxygen-Dependent Regulation of Adipogenesis387
  • Section VI: Nervous System397
  • Chapter 27. Methods to Detect Hypoxia-Induced Ischemic Tolerance in the Brain399
  • Chapter 28. Proximal Middle Cerebral Artery Occlusion Surgery for the Study of Ischemia–Reoxygenat416
  • Chapter 29. Carotid Chemodenervation Approach to Study Oxygen Sensing in Brain Stem Catecholaminergi422
  • Chapter 30. Discovery of Oxygen-Responsive Genes in Pheochromocytoma Cells449
  • Section VII: General465
  • Chapter 31. Oxygen-Dependent Asparagine Hydroxylation467
  • Chapter 32. Deciphering the Oxygen Sensing Pathway by Microscopy488
  • Chapter 33. Identification of Cyclic AMP Response Element-Binding Protein-Dependent Transcriptional511
  • Section VIII: Wound Healing525
  • Chapter 34. Determination of the Role of Hypoxia- Inducible Factor 1 in Wound Healing527
  • Chapter 35. Measuring Oxygen in Wounds539
  • Chapter 36. Regulatory Role of Lactate in Wound Repair565
  • Chapter 37. Protocols for Topical and Systemic Oxygen Treatments in Wound Healing575
  • Section IX: Unicellular Systems587
  • Chapter 38. Measurement of Oxidative Stress in Cells Exposed to Hypoxia and Other Changes in Oxygen589
  • Chapter 39. Evaluation of Oxygen Response Involving Differential Gene Expression in Chlamydomonas re604
  • Chapter 40. Resonance Raman and Ligand-Binding Analysis of the Oxygen-Sensing Signal Transducer Prot618
  • Chapter 41. Analysis of Fumarate Nitrate Reductase Regulator as an Oxygen Sensor in Escherichia coli628
  • Chapter 42. Experimental Strategies for Analyzing Oxygen Sensing in Yeast644
  • Section X: Physical Detection of Oxygen663
  • Chapter 43. Measuring Tissue PO2 with Microelectrodes665
  • Chapter 44. Identifying Oxygen Sensors by Their Photochemical Action Spectra690
  • Chapter 45. Fabrication and In Vivo Evaluation of Nitric Oxide-Releasing Electrochemical Oxygen-Sens704
  • Chapter 46. Methods in Optical Oxygen Sensing: Protocols and Critical Analyses715
  • Chapter 47. Concurrent 31P Nuclear Magnetic Resonance Spectroscopy and Fiber-Optic Oxygen Consumptio735
  • Chapter 48. Microximetry: Simultaneous Determination of Oxygen Consumption and Free Radical Producti747
  • Author Index763
  • Subject Index807
Book details
  • Vendor Elsevier S & T
  • SKU 9780121827854
  • ISBN-13 9780080497198
  • Author Semenza, Gregg L.
  • Category Medical
  • Subject Biochemistry

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The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.