Pathology and Pathogenesis of Human Viral Disease
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Table of contents
- Contentsix
- Prefacexv
- Acknowledgmentsxvii
- Chapter 1. Enteroviruses1
- Introduction1
- Virology and Epidemiology2
- Neurological Disease3
- Heart Disease10
- Striated Muscle Disease16
- Epidemic Myalgia Pleurodynia, Bomholm Disease17
- Lung Disease18
- Testicular Disease18
- Liver Disease19
- Kidney Disease19
- Placental Lesions of Neonatally Infected Infants19
- Skin and Mucus Membrane Disease20
- Type I Diabetes Mellitus21
- Chapter 2. Rhinoviruses29
- Chapter 3. Influenza Viruses35
- Influenza Viruses35
- Risk Factors39
- Lung Disease40
- Heart Disease41
- Muscle Disease43
- Salivary Gland Disease43
- Central Nervous System Disease43
- Reye-Johnson Syndrome43
- Chapter 4. Parainfluenza Viruses47
- Chapter 5. Respiratory Syncytial Virus (RSV)53
- Chapter 6. Herpesviruses: General Principles61
- Introduction61
- Cellular Virus Replication61
- Herpesvirus Latency62
- Herpesvirus Cytopathology (Alpha and Beta)63
- Chapter 7. Herpes Simplex Virus (HSV) Types 1 and 265
- Introduction65
- Primary and Recurrent Oral and Skin Infections65
- Urogenital Tract Disease66
- Generalized Systemic Disease69
- Central Nervous System Disease71
- Respiratory Tract Disease75
- Digestive Tract Disease76
- Liver Disease77
- Lymph Node Disease78
- Eye Disease78
- Chapter 8. Cytomegalovirus87
- Historical Overview87
- Cytomegalic Inclusion Body Cells88
- Epidemiology and Natural History89
- Congenital CMV Infection and Disease90
- Placental Infection and Diseases92
- Infections of Immunologically Intact Children and Adults92
- Mononucleosis and the Posttransfusion Syndrome93
- Nervous System Infection and Disease93
- Pulmonary Infection and Disease96
- Digestive Tract Infection and Disease100
- Liver Infection and Disease101
- Pancreas Infection and Disease102
- Genitourinary Tract Infection and Disease102
- Myocardial Infection and Disease105
- Eye Disease106
- Ear Disease107
- Possible Role of CMV in Atherosclerosis107
- Chapter 9. Epstein-Barr Virus (EBV)117
- Introduction and Historical Overview117
- Cellular and Molecular Biology of EBV118
- Infectious Mononucleosis120
- X-Linked Lymphoproliferative Disease (XLP) (Duncan's Disease)123
- Burkitt's Lymphoma (BL)124
- Lymphoproliferative Disorders (LPDs) Associated with Immunosuppression127
- Non-Hodgkin's Lymphoma129
- Hodgkin's Disease (HD)130
- Nasopharyngeal Carcinoma (NPC)131
- Lymphoepitheliomatous Gastric Carcinoma133
- Sinonasal Tumors133
- Pulmonary Disease134
- Lymphomatoid Granulomatosis135
- Inflammatory Pseudotumors135
- Sjögren's Syndrome and Salivary Gland Tumors135
- Hairy Leukoplakia (HCL)136
- Virus-Associated Hematophagocytic Syndrome138
- Chapter 10. Varicella-Zoster Virus (VZV)147
- Introduction and Historical Overview147
- Disseminated Childhood VZV Infection of the Skin: Chickenpox147
- Hemorrhagic VZV Infections of the Skin149
- Chronic VZV Infections of the Skin150
- Nervous System Disease151
- Eye Disease156
- Ear Disease158
- Pulmonary Disease158
- Digestive Tract Disease159
- Liver Disease159
- Renal Disease160
- Testicular Disease162
- Heart Disease162
- Joint, Synovial, and Muscle Diseases162
- Congenital VZV Infection162
- Chapter 11. Herpesvirus Type 6 (HHV-6)167
- Chapter 12. Kaposi Sarcoma-Associated Herpesvirus (KSHV, HHV-8)171
- Introduction171
- Epidemiology173
- Pathogenesis and Pathology174
- Angiosarcomas and Other Vascular Lesions178
- Body Cavity-Based Non-Hodgkin's Lymphoma (BCBL)178
- Angiofollicular Lymph Node Hyperplasia180
- Chapter 13. Herpesvirus Simiae Virus (Herpes B)187
- Chapter 14. Adenoviruses189
- Introduction189
- Epidemiology189
- Respiratory Tract Disease191
- Disease in Immunosuppressed Patients195
- Genitourinary Tract Disease196
- Digestive Tract Disease197
- Myocardial Disease197
- Central Nervous System Disease197
- Eye Disease198
- Chapter 15. Retroviruses: General Principles203
- Chapter 16. Human Immunodeficiency Viruses205
- Human Immunodeficiency Viruses 1 and 2 (HIV-1 and HIV-2)205
- HIV-1 Clinical Course in Adults207
- HIV-1 Clinical Course in Infants and Children210
- Persistent Generalized Lymphadenopathy (PGL) (syn. Progressive Generalized Lymphadeopathy)212
- Diseases of the Hematopoietic System215
- Diseases of the Central Nervous System216
- Diseases of the Respiratory Tract222
- Diseases of the Heart226
- Diseases of the Vasculature227
- Diseases of the Kidney228
- Diseases of the Testis229
- Diseases of the Digestive Tract230
- Tubuloreticular Structures (TRSs) and Cylindrical Confronting Cisternae (CCC)231
- Lymphomas231
- Kaposi's Sarcoma232
- Cervical Cancer234
- Chapter 17. Human T Cell Leukemia/Lymphoma Viruses (HTLV-1 and -2)243
- Introduction243
- T Cell Leukemia/Lymphoma (TLL) Syndrome244
- Tropical Spastic Paraparesis (TSP)247
- Inflammatory Conditions Associated with HTLV-1 Infection248
- HTLV-2249
- Chapter 18. Hepatitis Viruses253
- Introduction253
- Orally Acquired Short-Incubation-Period Acute Hepatitis254
- Parentally Acquired Long-Incubation-Period Acute and Chronic Hepatitis257
- Chronic Hepatitis (CH)262
- Hepatocellular Carcinoma (HCC)264
- Autoimmune Hepatitis (AH)270
- Papillary Acrodermatitis (Gianotti-Crosti Syndrome; GCS)271
- Glomerulonephritis272
- Chapter 19. Hemorrhagic Fever Viruses277
- Introduction277
- Arenaviruses277
- Bunyaviruses282
- Filoviruses287
- Flaviviruses289
- Chapter 20. Hantavirus Pulmonary Syndrome (HPS)297
- Chapter 21. Papillomaviruses303
- Introduction303
- Disease of the Skin305
- Disease of the Female Genital Tract308
- Disease of the Glans Penis314
- Disease of the Digestive Tract315
- Disease of the Larynx and Tracheobronchial Tree317
- Disease of the Eye321
- Disease of the Middle Ear322
- Chapter 22. Papovaviruses327
- Introduction327
- Progressive Multifocal Leukoencephalopathy (PML)329
- Urinary Tract Infection and Disease331
- Chapter 23. Parvoviruses335
- Introduction335
- Joint Disease337
- Erythropoietic Systemic Disease337
- Infections in Pregnancy339
- Inflammatory Lesions340
- Tissue Diagnosis340
- Chapter 24. Neurotropic Arthropod- Transmitted Viruses343
- Introduction343
- Togaviruses (Alphaviruses)344
- Flaviviruses349
- Bunyaviruses354
- Reoviruses354
- Chapter 25. Rabiesviruses357
- Introduction357
- Epidemiology357
- Clinical Disease358
- Pathogenesis359
- Central Nervous System Disease360
- Chapter 26. Poxviruses365
- Introduction365
- Orthopoxviruses366
- Parapoxviruses375
- Molluscipoxviruses377
- Chapter 27. Mumps381
- Introduction381
- Salivary Gland Disease382
- Central Nervous System Disease382
- Testicular Disease383
- Pancreatic Disease384
- Mumps-Associated Diabetes Mellitus385
- Ear Disease386
- Joint Disease386
- Chapter 28. Rubellavirus389
- Introduction389
- Naturally Acquired Postnatal Infections390
- Congenitally Acquired Infections391
- Chapter 29. Rubeola (Measles)397
- Introduction397
- Respiratory Tract Disease399
- Atypical Measles Syndrome402
- Central Nervous System Disease403
- Middle Ear Disease407
- Eye Disease407
- Pregnancy407
- Chapter 30. Transmissible Spongiform Encephalopathy411
- Introduction411
- Scrapie412
- Human Spongiform Encephalopathies: Clinical Features412
- Human Spongiform Encephalopathies: Pathological Features415
- Prions (Protein Infectious Organisms)417
- New Variant CJD (vCJD)421
- Iatrogenic CJD422
- Precautions for Pathologists422
- Ancillary Nonhistopathological Diagnostic Approaches of the Prion Diseases424
- Chapter 31. Lymphocytic Choriomeningitis Virus (LCMV)427
- Chapter 32. Enteric Viral Disease431
- Introduction431
- Norwalk-Like Viruses (NLVs)432
- Rotaviruses (RVs)433
- Additional Enteric Viruses438
- Pathophysiology of Viral Enteritis439
- Index441
Pathology and Pathogenesis of Human Viral Disease is a comprehensive reference that examines virus-induced clinical disease of humans in the context of the responsible virus and its epidemiology. Encompassing everything from cold and flu viruses to sexually transmitted diseases, this important resource describes the cellular and tissue pathological changes attributable to infection in the context of the pathogenic mechanisms involved. The author provides a comprehensive review of the older and contemporary literature, considering both the common and much rarer complications of infection.
Pathology and Pathogenesis of Human Viral Disease is written from the unique perspective of the clinical pathologist. It will help clinicians and pathologists gain a better understanding of changes that occur in viral infected cells, tissues, and organs. It will also serve as a pathology source book for virologists, internists, and pediatricians.
Key Features
* Provides a comprehensive, worldwide perspective of viral disease pathology
* Bridges the fields of pathology and virology; integrating clinical disease with cell and tissue pathology
* Addresses topics from the perspective of the clinical pathologist
* Illustrates unique, viral induced pathological lesions
* Considers common and uncommon complications of infection
Pathology and Pathogenesis of Human Viral Disease is written from the unique perspective of the clinical pathologist. It will help clinicians and pathologists gain a better understanding of changes that occur in viral infected cells, tissues, and organs. It will also serve as a pathology source book for virologists, internists, and pediatricians.
Key Features
* Provides a comprehensive, worldwide perspective of viral disease pathology
* Bridges the fields of pathology and virology; integrating clinical disease with cell and tissue pathology
* Addresses topics from the perspective of the clinical pathologist
* Illustrates unique, viral induced pathological lesions
* Considers common and uncommon complications of infection