Elsevier S & T

Pediatrics in Systemic Autoimmune Diseases

Cimaz, Rolando; Lehman, Thomas J.A.

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Table of contents
  • Cover
  • Contentsxiii
  • Prefacev
  • Series Editorvii
  • Volume Editorsix
  • List of Contributorsxi
  • Chapter 1. Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis1
  • 1. Introduction1
  • 2. Prevalence/epidemiology2
  • 3. Etiology and pathogenesis2
  • 4. Clinical manifestations4
  • 5. Diagnostic investigations5
  • 6. Differential diagnosis7
  • 7. Treatment8
  • 8. Prognosis10
  • References10
  • Chapter 2. The Juvenile-Onset Spondyloarthritides15
  • 1. Introduction15
  • 2. Epidemiology17
  • 3. Pathogenesis17
  • 4. Clinical manifestations18
  • 5. Clinical forms21
  • 6. Therapeutic approach26
  • References29
  • Chapter 3. Systemic Juvenile Idiopathic Arthritis35
  • 1. Introduction35
  • 2. Prevalence and epidemiology35
  • 3. Pathogenesis of S-JIA35
  • 4. Common clinical manifestations37
  • 5. Growth39
  • 6. Less common clinical manifestations41
  • 7. Macrophage activation syndrome42
  • 8. Laboratory investigations44
  • 9. Radiologic investigations44
  • 10. Differential diagnosis45
  • 11. Treatment47
  • 12. Disease course, outcome and prognosis48
  • 13. Mortality49
  • References50
  • Chapter 4. Macrophage Activation Syndrome55
  • 1. Introduction55
  • 2. Clinical features55
  • 3. Epidemiology56
  • 4. Nomenclature and classification57
  • 5. Pathogenesis58
  • 6. Diagnostic guidelines59
  • 7. Management60
  • References61
  • Chapter 5. Systemic Lupus Erythematosus: Etiology, Pathogenesis, Clinical Manifestations, and Manage65
  • 1. Introduction65
  • 2. Definition/classification65
  • 3. Epidemiology66
  • 4. Genetics66
  • 5. Etiology/pathogenesis66
  • 6. Clinical manifestations and treatment67
  • 7. General aspects of management72
  • 8. Course and prognosis73
  • 9. Alternate forms of lupus: neonatal, discoid, drug-induced73
  • References74
  • Chapter 6. Neonatal Lupus Syndromes77
  • 1. Introduction77
  • 2. Clinical features77
  • 3. Epidemiology78
  • 4. Pathogenesis79
  • 5. Prognosis81
  • 6. Treatment82
  • References84
  • Chapter 7. Juvenile Dermatomyositis89
  • 1. Introduction89
  • 2. Incidence of JDM89
  • 3. JDM epidemiology89
  • 4. Pathogenesis90
  • 5. Clinical manifestations90
  • 6. Diagnostic investigations93
  • 7. Diagnosis94
  • 8. Treatment95
  • Acknowledgements97
  • References97
  • Chapter 8. Localized Scleroderma in Children99
  • 1. Introduction99
  • 2. Epidemiology99
  • 3. Etiology and pathogenesis99
  • 4. Clinical manifestations100
  • 5. Diagnostic investigations102
  • 6. Treatment103
  • References105
  • Chapter 9. Juvenile Systemic Sclerosis107
  • 1. Introduction107
  • 2. Incidence and prevalence107
  • 3. Classification and epidemiology107
  • 4. Etiology/pathogenesis108
  • 5. Clinical manifestations108
  • 6. Diagnostic investigations113
  • 7. Differential diagnosis114
  • 8. Treatment115
  • References116
  • Chapter 10. Episodic Autoinflammatory Disorders in Children119
  • 1. Introduction119
  • 2. Familial Mediterranean Fever (FMF)119
  • 3. TNF-Receptor Associated Periodic Syndrome (TRAPS)121
  • 4. Hyper IgD Syndrome (HIDS)123
  • 5. Cryopyrin Associated Periodic Syndromes (CAPS)124
  • 6. Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne syndrome (PAPA)127
  • 7. Periodic Fever with Aphthous stomatitis, Pharyngitis and Adenitis (PFAPA)128
  • 8. Differential diagnosis131
  • Acknowledgements132
  • References132
  • Chapter 11. Kawasaki Disease137
  • 1. Introduction137
  • 2. Epidemiology137
  • 3. Etiology138
  • 4. Pathogenesis139
  • 5. Clinical manifestations139
  • 6. Laboratory findings140
  • 7. Atypical and incomplete KD141
  • 8. Infants and adolescents142
  • 9. Therapy144
  • 10. Cardiac follow-up145
  • 11. Vaccinations146
  • References147
  • Chapter 12. Henoch-Schönlein Purpura, Polyarteritis Nodosa, Wegener’s Granulomatosis, and Other V151
  • 1. Introduction151
  • 2. Classification151
  • 3. Henoch-Schönlein purpura151
  • 4. Polyarteritis nodosa155
  • 5. Wegener granulomatosis159
  • 6. Takayasu arteritis161
  • 7. Other vasculitides162
  • References164
  • Chapter 13. Pediatric Antiphospholipid Syndrome169
  • 1. Introduction169
  • 2. Prevalence of aPL169
  • 3. Epidemiology of APS171
  • 4. Etiology and pathogenesis172
  • 5. Clinical manifestations173
  • 6. Diagnostic investigations175
  • 7. Differential diagnosis176
  • 8. Treatment176
  • References177
  • Chapter 14. Behçet’s Disease181
  • 1. Introduction181
  • 2. Epidemiology181
  • 3. Etiology/pathogenesis182
  • 4. Clinical manifestations183
  • 5. Diagnostic investigations184
  • 6. Differential diagnosis185
  • 7. Treatment185
  • References186
  • Chapter 15. Childhood Sarcoidosis189
  • 1. Introduction189
  • 2. Epidemiology191
  • 3. Etiology/pathogenesis191
  • 4. Clinical manifestations195
  • 5. Diagnostic investigations201
  • 6. Differential diagnosis202
  • 7. Treatment and prognosis204
  • References205
  • Chapter 16. Rheumatic Fever209
  • 1. Introduction209
  • 2. Prevalence209
  • 3. Epidemiology209
  • 4. Etiology/pathogenesis209
  • 5. Clinical manifestations210
  • 6. Diagnosis212
  • 7. Treatment214
  • References215
  • Chapter 17. Lyme Borreliosis219
  • 1. Introduction219
  • 2. Persistent infection219
  • 3. Immunopathological reactions220
  • 4. Autoimmunity220
  • 5. Conclusions220
  • References221
  • Chapter 18. TNF-Inhibitors in Pediatric Rheumatology223
  • 1. Introduction223
  • 2. TNF in the pathogenesis of JIA224
  • 3. Adverse events of TNFα blockade228
  • 4. TNFα-inhibitors in juvenile dermatomyositis232
  • 5. TNFα-inhibitors in other pediatric rheumatic diseases232
  • 6. Conclusions233
  • References234
  • Chapter 19. Autologous Stem Cell Transplantation (ASCT) for Drug Resistant Systemic Onset Juvenile I241
  • 1. Rational of autologous stem cell transplantation for autoimmune disease241
  • 2. Autologous stem cell transplantation for juvenile idiopathic arthritis242
  • 3. Clinical results243
  • 4. Mechanisms of tolerance induction by ASCT244
  • Reference247
  • Chapter 20. Physical Therapy Management of Pediatric Rheumatology Conditions251
  • 1. Physical therapy management251
  • 2. Information to be gained from the subjective assessment251
  • 3. Objective assessment256
  • 4. Physical therapy management258
  • References265
  • Subject Index269
  • Colour Plate SectionColour Pla
Book details
  • Vendor Elsevier S & T
  • SKU 9780444529718
  • ISBN-13 9780080553443
  • Author Cimaz, Rolando; Lehman, Thomas J.A.
  • Category Medical
  • Subject Immunology

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Many of the systemic autoimmune diseases seen in children are different from those seen in adults making them a special problem for physicians and scientists who care for the affected children and study their diseases. Benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties, this volume covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices.