Elsevier S & T

Peptidases and Neuropeptide Processing: Volume 23

Conn, P. Michael

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Table of contents
  • Table of Contentsv
  • Contributors to Volume 23ix
  • Prefacexiii
  • Volumes in Seriesxv
  • Section I: Molecular Approaches for the Study of Intracellular Processing Enzymes1
  • Chapter 1. Molecular Strategies for Identifying Processing Enzymes3
  • Chapter 2. In Situ Hybridization Techniques to Map Processing Enzymes16
  • Chapter 3. Analysis of Ontogeny of Processing Enzyme Gene Expression and Regulation45
  • Chapter 4. Use of Vaccinia Virus Vectors to Study Neuropeptide Processing65
  • Chapter 5. Overexpression of Neuropeptide Precursors and Processing Enzymes94
  • Chapter 6. Use of Antisense RNA to Block Peptide-Processing Enzyme Expression109
  • Section II: Immunological and Biochemical Approaches to the Study of Peptide-Processing Pathways123
  • Chapter 7. Combination of High-Performance Liquid Chromatography and Radioimmunoassay for Characteri125
  • Chapter 8. Development and Use of Two-Site Immunometric Assays for Examining Peptide-Processing Path140
  • Chapter 9. Methods for Identification of Neuropeptide-Processing Pathways155
  • Chapter 10. Immunological and Related Techniques for Studying Neurohypophyseal Peptide-Processing Pa195
  • Chapter 11. Approaches to Assessing Ontogeny of Processing Enzymes208
  • Chapter 12. Measurement, Distribution, and Subcellular Localization of Peptide-Amidating Activity219
  • Chapter 13. Methods for Studying Carboxypeptidase E237
  • Chapter 14. Characterization of Endothelin-Converting Enzymes251
  • Chapter 15. In Vivo Approaches for Studying Peptide Processing266
  • Section III: Identification and Characterization of Extracellular Processing Enzymes in the Central279
  • Chapter 16. Identification and Characterization of Central Nervous Peptidase Activities281
  • Chapter 17. Strategies for Characterizing, Cloning, and Expressing Soluble Endopeptidases296
  • Chapter 18. Proteolytic Processing and Amyloid Protein Precursor of Alzheimer's Disease317
  • Chapter 19. Strategies for Measurement of Angiotensin and Bradykinin Peptides and Their Metabolites328
  • Chapter 20. Distribution and Roles of Endopeptidase 24.11344
  • Chapter 21. Identification and Distribution of Endopeptidase 24.16 in the Central Nervous System363
  • Chapter 22. Autoradiographic Techniques to Map Angiotensin-Converting Enzyme in Brain and Other Tiss383
  • Index399
  • Color Plate SectionColor Plate-1
Book details
  • Vendor Elsevier S & T
  • SKU 9780121852931
  • ISBN-13 9780080536422
  • Author Conn, P. Michael
  • Category Science
  • Subject Organic

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The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike.

Comprehensive protocols included for:
* Enzymes involved in the activation of bioactive peptidases and proteins
* Prohormone/neuropeptide processing pathways
* Enzymes involved in peptide metabolism
* Posttranslational processing enzymes