Plasticity in the Adult Brain: From Genes to Neurotherapy: From Genes to Neurotherapy
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Table of contents
- PLASTICITY IN THE ADULT BRAIN: FROM GENES TO NEUROTHERAPYiii
- Copyright Pageiv
- Contentsxiii
- List of Contributorsv
- Prefaceix
- Acknowledgementsxi
- Section I: Neurogenesis in adulthood: New neurons in old brains1
- Chapter 1. Neurogenesis in adult primates3
- Section II: Brain plasticity: From molecule to neural network15
- Chapter 2. Semaphorins: contributors to structural stability of hippocampal networks?17
- Chapter 3. Neurotrophins and visual cortical plasticity39
- Chapter 4. Dendritic spines: elementary structural units of neuronal plasticity53
- Chapter 5. Abnormal plastic changes in a rat model for mesial temporal lobe epilepsy: a short review61
- Chapter 6. Cortical map plasticity in animals and humans73
- Section III: Learning and memory89
- Chapter 7. A brain adaptation view of plasticity: is synaptic plasticity an overly limited concept?91
- Chapter 8. Environmental enrichment and the brain109
- Chapter 9. Sex hormones, neuroprotection and cognition135
- Chapter 10. Memory reactivation and consolidation during sleep: from cellular mechanisms to human pe143
- Chapter 11. Sensory loss and cortical reorganization in mature primates167
- Chapter 12. Human brain plasticity: evidence from sensory deprivation and altered language experienc177
- Section IV: Circadian and seasonal plasticity189
- Chapter 13. Modes of plasticity within the mammalian circadian system191
- Chapter 14. Functional plasticity of the circadian timing system in old age: light exposure205
- Chapter 15. What is the adaptive role of neurogenesis in adult birds?233
- Chapter 16. A brain for all seasons: cellular and molecular mechanisms of photoperiodic plasticity255
- Section V: Neural plasticity in aging and neuropathology281
- 17. Regulation of synaptic plasticity in memory and memory decline with aging283
- 18. Synaptic plasticity in the diabetic brain: advanced aging?305
- 19. Adult neurogenesis: implications for psychiatry315
- 20. Brain aging and Alzheimer’s disease; use it or lose it343
- 21. Functional genomics and psychiatric illness375
- Section VI: Cell implantation and gene therapy395
- Chapter 22. The fifteenth C.U. Ariëns Kappers Lecture (An introduction)397
- Chapter 23. New strategies in neural repair401
- Chapter 24. Regulation of dopamine cell type and transmitter function in fetal and stem cell transpl411
- Chapter 25. Neuroprotection for Parkinson’s disease using viral vector-mediated delivery of GDNF421
- Section VII: Stem cells: Their role in brain repair433
- Chapter 26. Glial stem-like cells: implications for ontogeny, phylogeny, and CNS regeneration435
- Chapter 27. Induced neurogenesis by endogenous progenitor cells in the adult mammalian brain451
- Chapter 28. The use of human embryonic stem cells for research: an ethical evaluation465
- Subject Index471
In the past decade neuronal plasticity has become a major theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in worms and insects to behavioural recovery from strokes in elderly humans. For this reason the focus of interest in the present volume of Progress in Brain Research is on the topic of neuroplasticity in mature organisms, including humans. Contributions range from neurogenesis and synaptic plasticity in the adult primate brain, to neural mechanisms of learning and memory, and the influence of environmental factors and aging on the functional potential of the central nervous system. Several contributions focus on recent developments in neural regeneration and brain repair, providing challenging evidence that the use of stem cell neurotherapy may be beneficial to humans suffering from various neurological and psychiatric diseases. This volume integrates new information on the cellular and molecular mechanisms of neuroplasticity and highlights challenging future questions in this exciting and topical area of neuroscience.