Post-Genomic Cardiology

Marín-García, José

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Table of contents
  • Contentsv
  • Prefacevii
  • Section I: Biochemical, Cellular, and Molecular Functioning of the Heart1
  • Chapter 1. Introduction to Post-Genomic Cardiology3
  • Chapter 2. Molecular and Biochemical Methodology in the Post-Genomic Era11
  • Chapter 3. Cardiovascular Gene Expression27
  • Chapter 4. Cellular Techniques51
  • Chapter 5. Cardiovascular Signaling Pathways77
  • Section II: Pediatric Cardiology in the Post-Genomic Era115
  • Chapter 6. Cardiac Development: Molecular and Genetic Analysis117
  • Chapter 7. Congenital and Acquired Heart Disease165
  • Section III: Post-Genomic Analysis of Coronary Artery Disease, Angiogenesis, and Hypertension209
  • Chapter 8. Molecular Basis of Lipoprotein Disorders, Atherogenesis, and Thrombosis211
  • Chapter 9. Ischemia and Myocardial Infarction: A Post-Genomic Analysis261
  • Chapter 10. Cellular Pathways and Molecular Events in Cardioprotection281
  • Chapter 11. Cardiac Neovascularization: Angiogenesis, Arteriogenesis, and Vasculogenesis315
  • Chapter 12. Systemic and Pulmonary Hypertension341
  • Section IV: Post-Genomic Analysis of the Myocardium361
  • Chapter 13. Cardiomyopathies363
  • Chapter 14. Heart Response to Inflammation and Infection415
  • Section V: The Failing Heart439
  • Chapter 15. Molecular Analysis of Heart Failure and Remodeling441
  • Section VI: Molecular and Genetic Analysis of Metabolic Disorders471
  • Chapter 16. Fatty Acid and Glucose Metabolism in Cardiac Disease473
  • Section VII: Molecular Genetics of Dysrhythmias511
  • Chapter 17. Dysrhythmias and Sudden Death513
  • Section VIII: Genes, Gender, and Environment553
  • Chapter 18. Gender and Cardiovascular Disease555
  • Section IX: Aging and the Cardiovascular System577
  • Chapter 19. The Aging Heart: A Post-Genomic Appraisal579
  • Section X: Looking to the Future617
  • Chapter 20. Future of Post-Genomic Cardiology619
  • Section XI637
  • Glossary639
  • Index657
Book details
  • Vendor Elsevier S & T
  • SKU 9780123736987
  • ISBN-13 9780080554549
  • Author Marín-García, José
  • Category Medical
  • Subject Cardiology

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Recent advances in molecular and cellular biology have markedly changed our understanding of the heart, and this is having tremendous ramifications for the clinician. This unique reference offers a comprehensive and critical evaluation of this contribution in the field of cardiovascular molecular medicine providing the reader with a sense of new directions in which molecular medicine might be applied. It begins with a detailed primer that makes readily accessible recent molecular, genetic and cellular techniques. Rounding out the coverage of this exciting field are critical and comprenhesive discussions on the use of molecular, genetic and cellular techniques used to identify the etiology and pathophysiology of specific cardiac diseases.

* Discusses diagnostic and therapeutic options available not only in the adult and aging individuals but also in infants/children
* Numerous illustrations and flow-charts
* Explans cutting-edge molecular techniques, including analysis of mitochondria, their role in cardiac dysfunction and updated analysis of Cardioprotection and Metabolic Syndrome
* Presentation of recent translational studies for the treatment of cardiovascular diseases is included (e.g., gene therapy, pharmacological treatments and stem cell transplantation)