Elsevier S & T

Principles of Bone Biology, Two-Volume Set

John P. Bilezikian

In stock

No reviews

218.250 KD inc. VAT

License

perpetual

Table of contents

Contentsv
Contributorsxix
Preface to the Second Editionxxvii
Preface to the First Editionxxix
Volume 11
Part I: Basic Principles1
A. Cell Biology3
Chapter 1. Structure and Development of the Skeleton3
Chapter 2. Biomechanics of Bone17
Chapter 3. Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endocho33
Chapter 4. Mesenchymal Stem Cells and Osteoblast Differentiation59
Chapter 5. Transcriptional Control of Osteoblast Differentiation and Function83
Chapter 6. The Osteocyte93
Chapter 7. Cells of Bone: Osteoclast Generation109
Chapter 8. Osteoclast Function: Biology and Mechanisms127
Chapter 9. Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Func141
Chapter 10. Apoptosis in Bone Cells151
Chapter 11. Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells169
B. Biochemistry189
Chapter 12. Type I Collagen: Structure, Synthesis, and Regulation189
Chapter 13. Collagen Cross-Linking and Metabolism211
Chapter 14. Bone Matrix Proteoglycans and Glycoproteins225
Chapter 15. Osteopontin239
Chapter 16. Bone Proteinases251
Chapter 17. Integrins and Other Cell Surface Attachment Molecules of Bone Cells265
Chapter 18. Intercellular Junctions and Cell–Cell Communication in Bone287
C. Bone Remodeling and Mineral Homeostasis303
Chapter 19. Histomorphometric Analysis of Bone Remodeling303
Chapter 20. Phosphorus Homeostasis and Related Disorders321
Chapter 21. Magnesium Homeostasis339
Chapter 22. Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, and Strontium359
Chapter 23. Biology of the Extracellular Ca2+-Sensing Receptor (CaR)371
Chapter 24. Receptors for Parathyroid Hormone (PTH) and PTH-Related Peptide389
Chapter 25. Parathyroid Hormone: Molecular Biology407
Chapter 26. Parathyroid Hormone– Receptor Interactions423
Chapter 27. Actions of Parathyroid Hormone463
Chapter 28. Renal and Skeletal Actions of Parathyroid Hormone (PTH) and PTH-Related Protein483
Chapter 29. Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein: Epidermal, M515
Chapter 30. Vascular, Cardiovascular, and Neurological Actions of Parathyroid-Related Protein531
Chapter 31. 1a, 25(OH)2Vitamin D3: Nuclear Receptor Structure (VDR) and Ligand Specificities for Gen545
Chapter 32. Vitamin D Gene Regulation573
Chapter 33. Photobiology and Noncalcemic Actions of Vitamin D587
Chapter 34. Structure and Molecular Biology of the Calcitonin Receptor603
Chapter 35. Calcitonin Gene Family of Peptides: Structure, Molecular Biology, and Effects619
Chapter 36. Amylin and Calcitonin Gene-Related Peptide641
E. Other Systemic Hormones That Influence Bone Metabolism655
Chapter 37. Estrogens and Progestins655
Chapter 38. Selective Estrogen Receptor Modulators677
Chapter 39. Mechanisms of Estrogen Action in Bone693
Chapter 40. Thyroid Hormone and Bone707
Chapter 41. Clinical and Basic Aspects of Glucocorticoid Action in Bone723
Chapter 42. Effects of Diabetes and Insulin on Bone Physiology741
Chapter 43. Androgens: Receptor Expression and Steroid Action in Bone757
Chapter 44. Kinins and Neuro-osteogenic Factors773
F. Local Regulators801
Chapter 45. The Role of Insulin-like Growth Factors and Binding Proteins in Bone Cell Biology801
Chapter 46. Platelet-Derived Growth Factor and the Skeleton817
Chapter 47. Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone825
Volume 2853
Chapter 48. Vascular Endothelial Growth Factors883
Chapter 49. Transforming Growth Factor-B903
Chapter 50. Bone Morphogenetic Proteins919
Chapter 51. Bone Morphogenetic Protein Receptors and Actions929
Chapter 52. Colony-Stimulating Factors943
Chapter 53. Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-#, IL-8, IL-10, IL-4, the L961
Chapter 54. Prostaglandins and Bone Metabolism979
Chapter 55. Nitric Oxide and Other Vasoactive Agents995
Part II: Molecular Mechanisims of Metabolic Bone Diseases1015
Chapter 56. Molecular Basis of PTH Overexpression1017
Chapter 57. Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism1031
Chapter 58. Multiple Endocrine Neoplasia Type 11047
Chapter 59. The Role of the RET Protooncogene in Multiple Endocrine Neoplasia Type 21067
Chapter 60. Systemic Factors in Skeletal Manifestations of Malignancy1079
Chapter 61. Local Factors in Skeletal Malignancy1093
Chapter 62. Molecular Basis of PTH Underexpression1105
Chapter 63. Jansen’s Metaphysical Chondrodysplasia and Blomstrand’s Lethal Chondrodysplasia: Two1117
Chapter 64. Pseudohypoparathyroidism1137
Chapter 65. Other Skeletal Diseases Resulting from G Protein Defects: Fibrous Dysplasia of Bone and1165
Chapter 66. Osteogenesis Imperfecta1177
Chapter 67. Hereditary Deficiencies in Vitamin D Action1195
Chapter 68. Oncogenic Osteomalacia1209
Chapter 69. Osteopetrosis1217
Chapter 70. Hypophosphatasia: Nature’s Window on Alkaline Phosphatase Function in Man1229
Chapter 71. Paget’s Disease of Bone1249
Chapter 72. Genetic Determinants of Bone Mass and Osteoporotic Fracture1259
Chapter 73. Pathophysiology of Osteoporosis1275
Chapter 74. Evaluation of Risk for Osteoporosis Fractures1291
Part III: Pharmacological Mechanisms of Therapeutics1303
Chapter 75. Parathyroid Hormone1305
Chapter 76. Calcium1325
Chapter 77. Calcium Receptors as Novel Drug Targets1339
Chapter 78. Bisphosphonates: Mechanisms of Action1361
Chapter 79. Fluoride in Osteoporosis1387
Chapter 80. The Pharmacology of Estrogens in Osteoporosis1401
Chapter 81. Vitamin D and Analogs1407
Chapter 82. Molecular and Clinical Pharmacology of Calcitonin1423
Chapter 83. Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases1441
Chapter 84. Anabolic Steroid Effects on Bone in Women1455
Chapter 85. Estrogen Effects on Bone in the Male Skeleton1467
Chapter 86. Mechanisms of Exercise Effects on Bone1477
Part IV: Methods in Bone Research1489
Chapter 87. Application of Transgenic Mice to Problems of Skeletal Biology1491
Chapter 88. Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulato1503
Chapter 89. Current Methodologic Issues in Cell and Tissue Culture1529
Chapter 90. Biochemical Markers of Bone Metabolism1543
Chapter 91. Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry1573
Chapter 92. Controversial Issues in Bone Densitometry1587
Chapter 93. Macro- and Microimaging of Bone Architecture1599
Chapter 94. Transilial Bone Biopsy1625
Chapter 95. Animal Models in Osteoporosis Research1635
Chapter 96. Defining the Genetics of Osteoporosis: Using the Mouse to Understand Man1657
Index for Volumes 1 and 21667

Book details

Vendor Elsevier S & T
SKU 9780120986521
Author John P. Bilezikian
Edition 2nd
Category Medical
Subject Orthopedics

Do you have questions about this book?

Ask an expert!

Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics.
The most current and timely source of information about the biology and pathology of bone
Provides succinct coverage of the subject
Contributors include over 200 of the most respected researchers in the field
Extensive table of contents and index for easy reference
Easy-to-read and highly informative to both the newcomer and the initiated to the field
Spans the spectrum from molecular biology to in vivo pharmacology
Complete bibliography with each entry fully referenced for additional background reading
First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996

Instant delivery by email
Your access email arrives within minutes of checkout, with a sign-in link for each book — no shipping, no waiting.

Read on any device
Books open in VitalSource Bookshelf on your phone, tablet, or computer, online or offline. Your library is always available at aafaq.vitalsource.com — just log in with the email you used at checkout.

Lost the email?
Resend it to yourself in seconds from My eBook orders, or email cs@aafaqeducation.com and we'll help.