Elsevier S & T

Profiles of Drug Substances, Excipients and Related Methodology: Critical Compilation of pKa Values for Pharmaceutical Substances

Brittain, Harry G.

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Table of contents
  • Contentsv
  • Forewordvii
  • Acknowledgmentsix
  • Dedicationxi
  • Prefacexiii
  • Critical Compilation of pKa Values for Pharmaceutical Substances1
  • 1. Introduction1
  • 1.1. The IUPAC pKa compilations2
  • 1.2. Limitations of current pharmaceuticals pKa compilations4
  • 2. Evaluation of Methods for pKa Determination7
  • 2.1. Inherent precision7
  • 2.2. Physicochemical factors controlling the accuracy and precision of pKa values8
  • 2.3. Validation of data quality23
  • 3. pKa Values from Computer Programs24
  • 4. Summary of the Data Compilation26
  • References28
  • Appendix A35
  • Main List35
  • pKa Values Found with Significant Data Quality Information„Mainly Primary Literature35
  • Appendix B425
  • Supplementary List-pKa Values Found with Little or No Data Quality Information„Mainly Secondary Li425
  • Index627
  • Alphabetical Index of Drugs or Drug Related Compounds Found in pKa Database Files627
  • Subject Index725
Book details
  • Vendor Elsevier S & T
  • SKU 9780122608339
  • ISBN-13 9780080555966
  • Author Brittain, Harry G.
  • Category Medical
  • Subject Pharmacology

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Description eBook delivery & access Reviews
Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions will now also be augmented by publication of critical review chapters that summarize information related to the characterization of drug substances and excipients. This change is required to better meet the needs of the pharmaceutical communtiy and to allow the development of a timely vehicle for publishing review materials on this topic.



The scope of the Profiles series will encompass review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

* Presents comprehensive reviews covering all aspects of drug development and formulation of drugs
* Now encompassing critical review chapters
* Meets the information needs of the drug development community