PROG NUCLEIC ACID RES&MOLECULAR BIO V22
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Table of contents
- Cover
- Contentsv
- List of Contributorsix
- Abbreviations and Symbolsxi
- Some Articles Planned for Future Volumesxv
- Chapter 1. The -C-C-A End of tRNA and Its Role in Protein Biosynthesis1
- I . Introduction2
- II . Structure of the -N-C-C-A Terminus3
- III. Structure of Aminoacyl-tRNA10
- IV. Enzymic Modification of the 3' End of tRNA14
- V. Aminoacylation of tRNA23
- VI. Positional Specificity of Aminoacylation and Chemical ŽProofreadingŽ39
- VII. Binding of Aminoacyl-tRNA to Ribosomes46
- VIII. Ribosomal Peptidyltransferase Center59
- References63
- Chapter 2. The Mechanism of Action of Antitumor Platinum Compounds71
- I. Introduction71
- II. Chemical Features of Platinum Drugs75
- III. Biological Effects of Platinum Coordination Complexes Indicative of Reactions with DNA85
- IV. Biochemical Effects of Platinum Complexes Indicative of Reactions with DNA88
- V. Interaction of Platinum Compounds with DNA94
- VI. Repair of DNA Damage Induced by Platinum Complexes in Vivo110
- VII. Concluding Remarks128
- References129
- Chapter 3. DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair135
- I. Introduction135
- II. Models for Excision-Repair of DNA136
- III. DNA Glycosylases145
- IV. Endonucleases for Apurinic/Apyrimidinic Sites (AP Endonucleases)173
- V. Repair of Apurinic Sites in DNA by Alternative Pathways187
- References188
- Chapter 4. Naturally Occurring Nucleoside and Nucleotide Antibiotics193
- Introduction193
- I. Inhibitors of Protein Synthesis196
- II. Inhibitors of RNA Synthesis209
- III. Inhibitors of DNA Synthesis, DNA Viruses, and RNA Viruses239
- IV. Inhibitors of Adenosine Deaminase and Effectors of the Immune Response245
- V. Inhibitors of Cell- Wall Synthesis and Antifungal Agents249
- VI. Inhibitors of Purine and Pyrimidine lnterconversions266
- VII. Hyperesthetic and Hyperemic Agents269
- VIII. Cyclic-AMP Phosphodiesterase Inhibitors269
- IX. Miscellaneous Naturally Occurring Nucleosides270
- References272
- Chapter 5. Genetically Controlled Variation in the Shapes of Enzymes293
- I. Introduction293
- II. Internal Standardization294
- III. The Interaction of Protein Size and Charge during Electrophoresis295
- IV. Detecting "Hidden" Variation in Shape303
- V. The Nature of Cryptic Variants305
- VI. Major Unresolved Issues: Posttranslational Modification315
- VII. Novel Approaches to Electrophoresis321
- References325
- Chapter 6. Transcription Units for mRNA Production in Eukaryotic Cells and Their DNA Viruses327
- I. Introduction327
- II . Techniques for Defining Transcription Units329
- III. Definition of Transcription Units for mRNA331
- IV. The Precursor Relationship of Large Nuclear Primary Transcripts to mRNA337
- V. Recent Evidence on the Formation of mRNA from Primary Transcripts339
- VI. Models for the Regulation of Eukaryotic Gene Expression344
- VII. Conclusion349
- References350
- Note Added In Proof353
- Index355
- Contents of Previous Volumes358
PROG NUCLEIC ACID RES&MOLECULAR BIO V22