PROG NUCLEIC ACID RES&MOLECULAR BIO V39
Regular price
27.000 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Cover
- Contentsv
- Abbreviations and Symbolsix
- Some Articles Planned for Future Volumesxi
- Chapter 1. DNA–Protein Interactions: The Use of Synthetic Oligo- and Polynucleotides for Studying1
- I. Nonspecific DNA–Protein Complexes: Structural Studies in the System: fl Gene-5 Protein–Oligo(3
- II. Specific Protein–Nucleic Acid Interactions: Restriction Endonucleases EcoRII, Mval, and SsoII12
- III. Mechanism of Cleavage of DNA Duplexes by Endonucleases EcoRII, Mval, and SsoII41
- IV. Conclusion44
- References45
- Chapter 2. A Tale of Two Enzymes, Deoxycytidylate Deaminase and Thymidylate Synthase49
- I. Deoxycytidylate Deaminase: Historical Perspective49
- II. Thymidylate Synthase: Historical Perspective61
- III. Concluding Remarks75
- References76
- Chapter 3. Stable DNA Loops in Vivo and in Vitro: Roles in Gene Regulation at a Distance and in Biop81
- I. Historical Perspective82
- II. DNA Cyclization as a Model for Looping85
- III. Survey of Some Regulatory Systems in Which Stable DNA Loops Are Implicated in Action-at-a-Dista90
- IV. Interpretation of Length Dependence of DNA Looping110
- V. The Local Concentration Model and Topological Models for Regulatory Effects Involving DNA Looping118
- VI. Conclusions122
- References124
- Chapter 4. Mitochondrial Aminoacyl-tRNA Synthetases129
- I. Genetic System of Yeast Mitochondria130
- II. Mitochondrial Aminoacyl-tRNA Synthetases133
- III. Cloning of the Genes for Mitochondrial Aminoacyl-tRNA Synthetases139
- IV. Threonyl-tRNA Synthetases of Yeast Mitochondria141
- V. Degree of Sequence Conservation between Yeast Mitochondrial, Yeast Cytoplasmic, and Prokayotic Am142
- VI. Homologous Proteins within the Aminoacyl-tRNA Synthetase Family145
- VII. Catalytic Sites of Aminoacyl-tRNA Synthetases151
- References155
- Chapter 5. Ribosomal Frameshifting from–2 to +50 Nucleotides159
- I. Perspectives159
- II. Exploration of the Effects of Simple Sequence Context on Reading-frame Alignment163
- III. Further Observations on the Context of High-level Frameshifts177
- References181
- Chapter 6. Inaccuracy and the Recognition of tRNA185
- I. Mischarging Mutants of GlnRS187
- II. Mischarging by Overproduction of Wild-type GlnRS193
- III. Mischarging of Mutant tRNAs by GlnRS197
- IV. The Structure of the GlnRS:tRNAGln Complex as It Relates to tRNAGin Identity201
- V. The Identity Elements of tRNAGin202
- VI. Mischarging by Other Aminoacyl-tRNA Synthetases203
- VII. Outlook204
- References206
- Chapter 7. Ribonucleases, tRNA Nucleotidyltransferase, and the 3' Processing of tRNA209
- I. Overview: 3' Terminus of tRNA209
- II. Encoding of the -C-C-A Sequence210
- III. Outline of tRNA Processing212
- IV. RNases Active at the 3' Terminus of tRNA and tRNA Precursors220
- V. tRNA Nucleotidyltransferase233
- VI. Regulation at the 3' Terminus of tRNA237
- References237
- Chapter 8. The Numerous Modified Nucleotides in Eukaryotic Ribosomal RNA241
- I. Introduction242
- II. Types and Numbers of Modified Nucleotides243
- III. Locations of Modified Nucleotides in the rRNA Sequences252
- IV. Diversity of Modification Sites in Relation to Local Primary Structure265
- V. Modified Nucleotides in the Secondary Structure270
- VI. rRNA Modification and Ribosome Maturation286
- VII. Outlook290
- References300
- Chapter 9. Damage to DNA and Chromatin Structure from Ionizing Radiations, and the Radiation Sensiti305
- I. Some Considerations of Single-Cell Survival Curves308
- II. Mechanisms of Energy Transfer312
- III. Chemical Protection and Radical Scavengers326
- IV. Strand Breakage in Cellular DNA327
- V. General Conclusions345
- Glossary346
- References347
- Index353
PROG NUCLEIC ACID RES&MOLECULAR BIO V39