Progress in Nucleic Acid Research and Molecular Biology
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Table of contents
- Cover
- Contentsv
- Some Articles Planned For Future Volumeix
- Chapter 1. Molecular Regulation, Evolutionary, and Functional Adaptations Associated with C to U Edi1
- I. RNA Editing: General Overview of Underlying Biochemical Mechanisms and Evolutionary Development2
- II. C to U RNA Editing5
- III. C to U ApoB RNA Editing: cis-Acting Elements14
- IV. C to U ApoB RNA Editing: trans-Acting Factors17
- V. Summary33
- Acknowledgments33
- References33
- Chapter 2. Polymorphisms in the Genes Encoding Members of the Tristetraprolin Family of Human Tandem43
- I. Introduction44
- II. Materials and Methods45
- III. Results52
- IV. Discussion63
- Acknowledgments66
- References66
- Chapter 3. Molecular and Cell Biology of Phosphatidylserine and Phosphatidylethanolamine Metabolism69
- I. Membrane Phospholipids70
- II. Pathways for Biosynthesis of Phosphatidylserine and Phosphatidylethanolamine71
- III. Enzymes of Phosphatidylserine Biosynthesis74
- IV. Enzymes of Phosphatidylethanolamine Biosynthesis82
- V. Regulation of PS and PE Biosynthesis85
- VI. Interorganelle Transport of PS and PE87
- VII. Intramembrane Transport of PS and PE92
- VIII. Biological Functions of PS and PE95
- IX. Future Directions97
- References98
- Chapter 4. DNA–Protein Interactions during the Initiation and Termination of Plasmid pT181 Rolling113
- I. Introduction114
- II. Origins of Replication of the Plasmids of the pT181 Family116
- III. Initiator Proteins of the Plasmid pT181 Family122
- IV. Mechanism of Inactivation of the Plasmid pT181 Family Rep Proteins126
- V. Role of Host Proteins in pT181 RC Replication129
- VI. Replication of the Lagging Strand of Plasmid pT181132
- VII. Conclusions and Future Directions133
- Acaknowldgment133
- References133
- Chapter 5. Herpes Simplex Virus Type-1: A Model for Genome Transactions139
- I. Introduction to Herpesviridae140
- II. HSV-1 Life Cycle, Genome Structure, and Replication Genes140
- III. Initiation of Replication144
- IV. Elongation151
- V. Interaction of the HSV-1 DNA Replication Machinery with DNA Damage155
- VI. Homologous Recombination159
- VII. Concluding Remarks163
- Acknowledgments165
- References165
- Chapter 6. Enzymology and Molecular Biology of Glucocorticoid Metabolism in Humans173
- I. Introduction174
- II. Glucocorticoid Action175
- III. The Free Hormone Hypothesis177
- IV. Glucocorticoid Receptors178
- V. Nongenomic Action of Glucocorticoids179
- VI. Glucocorticoid Resistance180
- VII. 11 b-Hydroxysteroid Dehydrogenase (11 b-HSD) as Prereceptor Control181
- VIII. Hydroxysteroid Dehydrogenases: Physiological Role .182
- IX. The History of Two Isoforms: 11 b-HSD Type 1 and 11 b-HSD Type 2182
- X. A (Patho)physiological Role for 11 b-HSD 1 and 11 b-HSD 2183
- XI. 11 -HSD 2 and the Syndrome of ‘‘Apparent Mineralocorticoid Excess’’ (AME)184
- XII. 11 b-Hydroxysteroid Dehydrogenase Type 1 (11 b-HSD 1)187
- XIII. Conclusions203
- References203
- Chapter 7. Dancing with Complement C4 and the RP-C4-CYP21-TNX (RCCX) Modules of the Major Histocompa217
- I. Introduction219
- II. The Sophisticated Genetic Diversities of Human C4 and RCCX Modules221
- III. Structural Diversities of the Human and Mouse C4 Proteins232
- IV. Nucleotide Polymorphisms in Human C4A and C4B Genes245
- V. Expression of C4A and C4B Transcripts and Proteins255
- VI. The Endogenous Retrovirus that Mediates the Dichotomous Size Variation of C4 Genes260
- VII. Evolution of Complement C3/C4/C5 and the RCCX Modules in the MHC267
- VIII. Afterthoughts: Eleven Outstanding Issues to be Addressed274
- Acknowledgments276
- References276
- Chapter 8. The Roles and Regulation of Potassium in Bacteria293
- I. Paths of K+ Movement296
- II. Regulation of K+ Transport Systems305
- III. K As An Intracellular Activator309
- IV. Regulation of Internal pH by K+311
- V. Future Directions312
- References313
- Chapter 9. Conformational Polymorphism of d(A-G)n and Related Oligonucleotide Sequences321
- I. Introduction321
- II. a-DNA HelixQAcid-Dependent Duplex Equilibrium323
- III. Acid-Dependent Parallel DuplexQpH-Independent Parallel Duplex Equilibrium332
- IV. pH-Independent Parallel DuplexQSingle-Hairpin DuplexQTwo-Hairpin Tetraplex Equilibria334
- V. Concluding Remarks342
- Acknowledgments344
- References344
- Index349
- Color Plate SectionColor Plat
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.
* Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology
* Includes contributions from the leaders in the field
* Has abundant references
* Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology
* Includes contributions from the leaders in the field
* Has abundant references