Elsevier S & T

Progress in Nucleic Acid Research and Molecular Biology

Moldave, Kivie

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Table of contents
  • Cover
  • Contentsv
  • Some Articles Planned for Future Volumesix
  • Chapter 1. Nuclear Receptor-Mediated Transactivation Through Interaction with Sp Proteins1
  • I. Sp1 Protein2
  • II. Sp/KLF Family of Proteins3
  • III. Cooperative Sp1 and Related Sp/KLF Protein Interactions with Other Transcription Factors4
  • IV. Interactions of Sp Family Proteins with Estrogen Receptors9
  • V. Interaction of Sp Family Proteins with Other Steroid Hormone Receptors and NRs20
  • VI. Summary23
  • References24
  • Chapter 2. Site-Specific DNA Damage Recognition by Enzyme-Induced Base Flipping37
  • I. Why Do Enzymes Flip Bases?39
  • II. Nonenzymatic Base Pair Breathing41
  • III. Enzymatic Base Flipping43
  • IV. New Experimental Approaches54
  • V. Future Directions60
  • References61
  • Chapter 3. Bacteriophage T2Dam and T4Dam DNA-[N6-adenine]-methyltransferases67
  • I. Historical Background68
  • II. Binding Properties of T4Dam73
  • III. Kinetic Properties of T4Dam Methylation of Substrate Duplexes Containing Native or Altered Reco84
  • IV. Structure of T4Dam112
  • V. Concluding Comments118
  • References120
  • Chapter 4. Site-Specific Recombination and Partitioning Systems in the Stable High Copy Propagation127
  • I. The Flp Site-Specific Recombination System130
  • II. The Shared Active Site of Flp: DNA Cleavage in trans135
  • III. The Geometry and Topology of Flp Recombination142
  • IV. The 2-Micron Circle Partitioning System151
  • V. Cohesin Disassembly is a Prerequisite for Separation of Plasmid Clusters161
  • VI. Summary and Perspectives164
  • References167
  • Chapter 5. Did an Early Version of the Eukaryal Replisome Enable the Emergence of Chromatin?173
  • I. Introduction173
  • II. Deep-Rooted Features of Two Replisome Types174
  • III. Coordinated Syntheses of the Opposite DNA Strands187
  • IV. Possible Implications of a Symmetrical Eukaryal Replication Fork196
  • References199
  • Chapter 6. Initiation and Elongation Factors in Mammalian Mitochondrial Protein Biosynthesis211
  • I. Mammalian Mitochondrial Protein Synthesis211
  • II. Initiation of Protein Biosynthesis in Mammalian Mitochondria214
  • III. Elongation Factors in Mammalian Mitochondria231
  • IV. Conclusions252
  • References253
  • Chapter 7. Cyclin Dependent Kinase 11 in RNA Transcription and Splicing263
  • I. Introduction263
  • II. CDK11 Gene Structure and Expression264
  • III. CDK11 Protein Isoforms and Regulation270
  • IV. CDK Regulation of RNA Transcription275
  • V. CDK11p110 Protein Complexes and Biological Function278
  • VI. Alterations in CDK11p110 Expression in Human Disease282
  • References283
  • Chapter 8. The Eukaryotic Ccr4-Not Complex: A Regulatory Platform Integrating mRNA Metabolism with C289
  • I. Introduction290
  • II. The Ccr4-Not Complex: Conserved in Composition and Organization292
  • III. Interaction of the Core Ccr4-Not Complex with Additional Proteins in Larger Structures298
  • IV. Role of the Yeast Ccr4-Not Complex in mRNA Metabolism305
  • V. Role of the Ccr4-Not Complex in Ubiquitylation312
  • VI. Role of the Ccr4-Not Complex in Protein Modification314
  • VII. The Ccr4-Not Complex as a Regulatory Platform that Senses Glucose Levels and Stress314
  • VIII. Perspectives316
  • References317
  • Chapter 9. Signaling Repression of Transcription by RNA Polymerase III in Yeast323
  • I. Introduction323
  • II. Coupling Plasma Membrane Expansion to Transcriptional Regulation of Ribosomal Components and tRN326
  • III. Nutrients, Starvation, and TOR Signaling335
  • IV. Repression of Pol III Transcription in Response to DNA Damage341
  • V. Maf1 and its Essential Role in Pol III Transcriptional Repression342
  • VI. Future Studies346
  • References348
  • Index355
Book details
  • Vendor Elsevier S & T
  • SKU 9780125400770
  • ISBN-13 9780080522715
  • Author Moldave, Kivie
  • Category Science
  • Subject Molecular Biology

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Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.