Progress in Nucleic Acid Research and Molecular Biology
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Table of contents
- Cover
- Title pageiii
- Copyright Pageiv
- Contentsv
- Some Articles Planned for Future Volumesix
- Chapter 1. Structure, Mechanism, and Evolution of the mRNA Capping Apparatus1
- I. Genetic and Physical Organization of the Cellular Capping Apparatus3
- II. Structure and Mechanism of mRNA Guanylyltransferase4
- III. Structure and Mechanism of Yeast RNA Triphosphatase12
- IV. Metazoan RNA Triphosphatase19
- V. Assembly of the Yeast Triphosphatase–Guanylyltransferase Complex22
- VI. Other RNA Triphosphatases of Unknown Function24
- VII. Cap Methyltransferase28
- VIII. Perspective34
- References35
- Chapter 2. Folding of a Nascent Peptide on the Ribosome41
- I. Introduction42
- II. RNA Binding Sites during Translation43
- III. Ribosomal RNA and Peptide Synthesis45
- IV. Nascent Peptides47
- V. Tunnel in the Large Ribosomal Subunit.51
- VI. Folding of Nascent Peptides54
- VII. Pause-Site Peptides55
- VIII. Chaperonelike Activity of Ribosomes56
- IX. Effects of Chaperones on Nascent Peptides57
- X. Problems and Prospects60
- References62
- Chapter 3. Exoribonucleases and Their Multiple Roles in RNA Metabolism67
- I. Overview of Exoribonuclease Diversity and Function68
- II. Catalog of Exoribonucleases.71
- III. Exoribonucleases in Multienzyme Complexes91
- IV. Concluding Remarks94
- References95
- Chapter 4. Protein Traffic in Bacteria: Multiple Routes From the Ribosome To and Across the Membrane107
- I. SecA/SecB-Dependent Targeting to the SecYE Translocon109
- II. SRP-Dependent Targeting to the SecYE Translocon115
- III. Is There a Concerted Targeting by SRP and SecA/SecB to the SecYE Translocon?123
- IV. Translocation and Integration at the SecYE Translocon124
- V. Spontaneous Insertion into the Plasma Membrane131
- VI. TAT-Specific Targeting and Export136
- VII. Posttranslocational Events in the Periplasmic Space138
- References141
- Chapter 5. The Intrinsically Unstable Life of DNA Triplet Repeats Associated with Human Hereditary D159
- I. Diseases Associated with Expansions of DNA Triplet Repeats.160
- II. Mechanisms of Disease Pathology Caused by Expansions of DNA Triplet Repeats165
- III. Molecular Mechanisms of Expansions and Deletions of DNA-Triplet Repeats169
- IV. Genetic Instabilities of Other Microsatellite Sequences189
- V. Summary and Future Prospects190
- References192
- Chapter 6. Molecular and Cell Biology of Acid B-Glucosidase and Prosaposin203
- I. Molecular and Cell Biology of Acid B-Glucosidase204
- II. Molecular Biology and Function of Prosaposin and Saposins211
- III. Multifunctional Roles of Saposin C and Prosaposin221
- IV. Conclusions.234
- References235
- Chapter 7. Regulation and Function of the Cyclic Nucleotide Phosphodiesterase (PDE3) Gene Family241
- I. Introduction242
- II. The PDE3 Gene Family247
- III. Hormonal Regulation of PDE3 Enzymes254
- IV. Long-Term Regulation of PDE3 Enzymes260
- V. Pharmacology and Potential Therapeutic Applications of PDE3 Inhibitors262
- VI. Present and Future Therapeutic Applications for PDE3 Inhibitors268
- References270
- Chapter 8. Understanding Nuclear Receptor Function: From DNA to Chromatin to the Interphase Nucleus279
- I. Identification of Regulatory Elements for Steroid Receptors279
- II. Chromatin Involvement in Gene Regulation by Steroid Receptors281
- III. Beyond the Chromatin Fiber: Receptor Traf.cking in Living Cells296
- References301
- Chapter 9. A Unique Combination of Transcription Factors Controls Differentiation of Thyroid Cells307
- I. Introduction308
- II. Expression, Biological Effects, and Molecular Characteristics of the Thyroid-Specific Transcript312
- III. Target Genes, Cooperativity, Recycling, and Regulation330
- IV. Thyroid-Speci.c Transcription Factors in Congenital Hypothyroidism339
- V. Conclusions and Perspectives341
- References343
- Chapter 10. Regulation of Metallothionein Gene Expression357
- I. Metallothionein Proteins358
- II. Probable Functions of Metallothioneins359
- III. Gene Structure of Mammalian Metallothioneins361
- IV. CIS-Acting Elements in MT-I Promoter362
- V. Trans-Acting Factors362
- VI. Basal Expression362
- VII. Heavy Metal–Induced Expression365
- VIII. Induction by Other Agents367
- IX. Tissue-Speci.c Expression370
- X. Role of Repressors371
- XI. Role of Chromatin Structure372
- XII. Regulation by Epigenetic Mechanism373
- XIII. Concluding Remarks378
- References379
- Index385
Description
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes.
Importance of Topic
Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology.
Why This Title
Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.
Key Features
* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology
* Features contributions from leaders in their fields
* Contains abundant references
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes.
Importance of Topic
Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology.
Why This Title
Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.
Key Features
* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology
* Features contributions from leaders in their fields
* Contains abundant references