Progress in Nucleic Acid Research and Molecular Biology
Regular price
64.750 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Cover
- Contentsv
- Some Articles Planned For Future Volumesix
- Chapter 1. Modulation of RNA Function by Oligonucleotides Recognizing RNA Structure1
- I. RNA Structures: Targets of Interest2
- II. Antisense Oligonucleotides5
- III. Triple-Stranded Complexes19
- IV. Oligonucleotides Identified through Combinatorial Approaches25
- V. Conclusion38
- References39
- Chapter 2. Regulation of the DNA Methylation Machinery and Its Role in Cellular Transformation47
- I. DNA Methylation Is a Covalent Epigenetic Modification of DNA49
- II. DNA Methylation Represses Gene Expression by Two Different Mechanisms50
- III. Enzymatic DNA Methylation Machinery53
- IV. Coordination of DNA Replication and DNA Methylation Machineries55
- V. Inhibition of DNMT1 Inhibits DNA Replication in Human Lung Cancer Cells63
- VI. DNMT1 and Oncogenesis64
- VII. Conclusions71
- References72
- Chapter 3. Lysosomal Multienzyme Complex: Biochemistry, Genetics, and Molecular Pathophysiology81
- I. Introduction82
- II. Discovery of Lysosomal Multienzyme Complex82
- III. Components of the Complex84
- IV. Composition, Stoichiometry, and Structure of Lysosomal Multienzyme Complex97
- V. Plasma Membrane Complex of Elastin-Binding Protein, Cathepsin A, and Sialidase98
- VI. Molecular Pathology of Lysosomal Multienzyme Complex99
- VII. Future Perspectives105
- References107
- Chapter 4. Phosphoribosylpyrophosphate Synthetase and the Regulation of Phosphoribosylpyrophosphate115
- I. PRPP and the PRPP Synthetase Reaction117
- II. PRPP Utilization119
- III. PRPP: Regulatory Role121
- IV. PRPP Synthetase125
- V. Regulation of PRPP Synthesis in Human Cells140
- References145
- Chapter 5. Ethanol Catabolism in Aspergillus nidulans: A Model System for Studying Gene Regulation149
- I. Identification of Three alc Genes and Their Products, Which Are Responsible for Ethanol Catabolis152
- II. AlcR: The Transcriptional Activator of the Ethanol Regulon in A. nidulans156
- III. Induction of the alc Gene System: The Inducer167
- IV. The CreA Repressor174
- V. Mechanism of Regulation of the alc Genes180
- VI. The alc System as a Heterologous Expression Tool in Fundamental Research and Biotechnology192
- VII. Conclusions and Prospects195
- References198
- Chapter 6. The ROR Nuclear Orphan Receptor Subfamily: Critical Regulators of Multiple Biological Pro205
- I. Introduction207
- II. Cloning and Expression Pattern of RORs208
- III. Structure of ROR Proteins212
- IV. Characterization of ROR Response Elements214
- V. Transcriptional Control by RORs217
- VI. Genomic Structure and Chromosomal Localization224
- VII. Targeted Knockouts of RORs226
- VIII. Overexpression of RORs236
- IX. Other Target Genes239
- X. Concluding Remarks241
- References242
- Chapter 7. PDE4 cAMP-Specific Phosphodiesterases249
- I. Entities Involved in cAMP Metabolism250
- II. Cyclic Nucleotide Phosphodiesterase Families253
- III. Cyclic Nucleotide Phosphodiesterases and Intracellular Targeting258
- IV. PDE4 cAMP-Specific Phosphodiesterases261
- V. PDE4 Gene Organization262
- VI. Domain Structure of PDE4 Isoenzymes266
- VII. Intracellular Targeting of PDE4 Isoforms279
- VIII. Phosphorylation288
- IX. Activation of PDE4A Isoforms through a PI-3 Kinase-Mediated Process298
- X. Activation of the Long PDE4D3 Isoform by Phosphatidic Acid300
- XI. Induction of PDE4 Isoforms301
- XII. PDE4 Knockouts304
- XIII. Conclusion305
- References306
- Chapter 8. Domain–Domain Communication in Aminoacyl-tRNA Synthetases317
- I. Function and Domain Organization of AARSs318
- II. Domain Functions Are Separable320
- III. Noncovalent Assembly of Aminoacylation Systems Demonstrating Capacity for Communication323
- IV. Examples of Domain–Domain Communication Revealed by Functional Analysis of Aminoacylation Effi325
- V. Understanding Communication Based on Structural Analysis330
- VI. Communication by Conformational Changes in tRNA Studied in Solution334
- VII. Communication in Aminoacylation That Requires Covalent Continuity of the tRNA Demonstrated by F335
- VIII. Domain Communication in Editing337
- IX. Role of Induced Fit341
- X. Conclusion345
- References346
- Index351
Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.