Progress in Nucleic Acid Research and Molecular Biology
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Table of contents
- Cover
- Contentsv
- Some Articles Planned For Future Volumeix
- Chapter 1. Lysyl Oxidases: A Novel Multifunctional Amine Oxidase Family1
- I. Conserved Structural and Functional Domains of Lysyl Oxidase (LOX)2
- II. LOXL, LOXL2, and LOXL3, Novel Members of the LOX Family3
- III. Genomic Structure and Chromosomal Localizations of the LOX and LOX-like Genes5
- IV. Evolutionary Relationships of the LOX Genes7
- V. Regulation of LOX and LOX-like Gene Expression8
- VI. Synthesis, Transport, and Processing of LOX and LOX-like Proteins13
- VII. The Catalytic Site and Amine Oxidase Activity of the LOX-like Proteins15
- VIII. Novel Functional LOX Domains: Cytokine Receptor-like and SRCR Domains.18
- IX. Tissue, Cell, and Developmental Expression of LOX and LOX-like Proteins.21
- X. Conclusion27
- References28
- Chapter 2. Distinct Regulatory Properties of Pyruvate Dehydrogenase Kinase and Phosphatase Isoforms33
- I. Introduction34
- II. Pyruvate Dehydrogenase Complex (PDC) System, Roles, and General Regulation36
- III. Kinase and Phosphatase Isoform Properties47
- IV. E2 Mediation of Activated Function and Regulatory Control of PDKs and PDP159
- References69
- Chapter 3. A Tale of Two HSV-1 Helicases: Roles of Phage and Animal Virus Helicases in DNA Replicati77
- I. Helicases Play Important Roles in Many Biological Processes78
- II. Helicases Contain Conserved Motifs79
- III. Roles of Helicases in Replication and Recombination83
- IV. Replication and Recombination in Large DNA Bacteriophages87
- V. Herpes Simplex Virus DNA Replication93
- VI. HSV-1 Encodes Two Helicases Required for Viral DNA Replication97
- VII. Concluding Remarks111
- References112
- Chapter 4. The RNA World of Plant Mitochondria119
- I. The Origin of Mitochondria121
- II. Transcription of Higher Plant Mitochondrial Genomes124
- III. Processing of Plant Mitochondrial mRNAs135
- IV. Processing of tRNAs and rRNAs142
- V. Posttranscriptional RNA Processing Involved in Cytoplasmic Male Sterility147
- References150
- Chapter 5. Multiple Controlling Mechanisms of FGF1 Gene Expression through Multiple Tissue-Specific155
- I. Fibroblast Growth Factor (FGF) Family156
- II. Role of FGF1 in Disease and Development157
- III. Tissue-Speci.c Expression of Multiple FGF1 Transcripts158
- IV. Cloning of the Human FGF1 Gene Locus Spanning 720 kbp and the Mouse FGF1 Gene159
- V. Characterization of the Brain-Specific FGF1.B Promoter160
- VI. Transcriptional Regulation of Vascular-Specific 1.C and 1.D Promoters167
- VII. Transgenic Mouse Tumors in Which the T Antigen Is Driven by the FGF1. B Promoter170
- VIII. Conclusion171
- References172
- Chapter 6. Structure and Function of Branched Chain Aminotransferases175
- I. Branched Chain Aminotransferases (BCATs)176
- II. Transamination176
- III. Identification of BCAT177
- IV. Identi.cation and Distribution of the Mammalian BCAT Isozymes178
- V. BCAT in Bacteria, Plants, Insects, and Lower Eukaryotes180
- VI. Substrate Specificity of the BCAT Enzymes181
- VII. Effects of Sulfhydryl Reagents183
- VIII. BCAT Michaelis Constants.183
- IX. Spectral and Physical Properties185
- X. Cloning and Structure of the BCAT Family Proteins188
- XI. Studies with Inhibitors and Substrate Analogs Provide Evidence Differences in the Structure and195
- XII. Future Directions201
- References201
- Chapter 7. Functional Significance and Mechanism of eIF5-Promoted GTP Hydrolysis in Eukaryotic Trans207
- I. General Overview of Translation Initiation208
- II. Translation Initiation Factor eIF5 Is a Monomeric Protein of about 50 kDa210
- III. Function of eIF5 in the Formation of the 80S Ribosomal Initiation Complex212
- IV. Cloning and Characterization of Mammalian cDNAs and the Yeast Saccharomyces cerevisiae Gene Enco215
- V. eIF5 Functions as a Canonical Translation Initiation Factor in Vivo in Yeast Cells216
- VI. Mammalian eIF5 Can Functionally Substitute for the Homologous Yeast Protein in the Yeast Sacchar217
- VII. Molecular Mechanism of eIF5-Promoted GTP Hydrolysis.217
- VIII. Perspectives and Future Directions227
- References230
- Chapter 8. Nonribosomal Biosynthesis of Microbial Chromopeptides233
- I. Introduction234
- II. Principles of Nonribosomal Peptide Synthesis235
- III. Modular Polyketide Synthases (PKS I) .241
- IV. Structural Features of Nonribosomal Chromopeptides243
- V. Modular Assembly Systems for Chromopeptide Synthesis249
- VI. Modular Assembly Systems for Chromopeptide–Siderophores in Bacteria264
- VII. Assembly Systems for Thiazole-Containing Peptides and Polyketides274
- VIII. Thiazole Ring Biosynthesis in Nonribosomal Peptides and Polyketides277
- IX. Conclusions and Future Prospects of Chromopeptide Biosynthesis282
- References284
- Chapter 9. Manipulation of tRNA Properties by Structure-Based and Combinatorial in Vitro Approaches291
- I. Background and Concepts292
- II. tRNA-Mimics Designed by Structure- and Rationale-Based Approaches296
- III. tRNA-Mimics Selected by Combinatorial Methods309
- IV. Summary and Outlook328
- References329
- Index335
Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.