Progress in Nucleic Acid Research and Molecular Biology
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Table of contents
- Cover
- Copyright Pageiv
- Contentsv
- Some Articles Planned for Future Volumesix
- Chapter 1. The Molecular Biology of Cyclic Nucleotide Phosphodiesterases1
- I. Introduction2
- II. Nomenclature3
- III. Overview of the Domain Organization of a Cyclic Nucleotide Phosphodiesterase4
- IV. Structure of the Genes Encoding Phosphodiesterases8
- V. Localization of the Phosphodiesterase Genes in the Human Genome and Association with Inherited Di12
- VI. Transcription Regulation of Phosphodiesterase Genes14
- VII. Regulation of mRNA Stability18
- VIII. Alternate Splicing and Function of PDE Variants19
- IX. Concluding Remarks31
- References33
- Chapter 2. PriA: At the Crossroads of DNA Replication and Recombination39
- I. Discovery and Initial Characterization40
- II. Helicase Activity and Primosome Function44
- III. Cloning and Structure–Function Analysis48
- IV. Characterization of priA Null Strains51
- V. PriA Binding to D Loops58
- VI. Replication Fork Assembly at D Loops61
- VII. Conclusions62
- References64
- Chapter 3. The Cell Biology of the Prohormone Convertases PC1 and PC269
- I. Prohormone Processing„General Features70
- II. The Cell Biology of PC173
- III. The Cell Biology of PC2 and Its Binding Protein 7B280
- IV. Are There Other 7B2-like Molecules in the Secretory Pathway?100
- V. Summary and Perspective: Future Research102
- References103
- Chapter 4. Transcriptional Regulation of Syndecan-1 Expression by Growth Factors109
- I. Structure of Syndecan-1110
- II. Functions of Syndecan-1111
- III. Expression of Syndecan-1113
- IV. Regulation of Syndecan-1 Expression115
- V. Growth Factor-Induced Transcriptional Regulation of Syndecan-1 by a Novel FGF-Inducible Response118
- VI. Discussion128
- References134
- Chapter 5. Retinoic Acid: Its Biosynthesis and Metabolism139
- I. Approaches to Identifying Enzymes That Catalyze Retinoid Metabolism140
- II. Retinoid-Binding Proteins141
- III. Effects of Retinoid-Binding Proteins on Enzyme Access to Retinoids146
- IV. A Model of Retinoic Acid Metabolic Homeostasis152
- V. Retinyl Ester Hydrolase159
- VI. Lecithin: Retinol Acyltransferase160
- VII. Retinol Dehydrogenases160
- VIII. Retinoid–Androgen Interactions167
- IX. Retinal Dehydrogenases170
- X. Retinoic Acid Metabolism174
- XI. Do Alcohol Dehydrogenases Function Universally in Retinoic Acid Biosynthesis?177
- XII. Does Ethanol Cause Fetal Alcohol Syndrome by Competitive Inhibition of Retinol Dehydrogenation?180
- References182
- Chapter 6. Genetic Disorders Associated with Cancer Predisposition and Genomic Instability189
- I. Introduction190
- II. Genomic Instability A Universal Aspect of Early Tumorigenesis?213
- References214
- Chapter 7. The Role of POU Domain Proteins in the Regulation of Mammalian Pituitary and Nervous Syst223
- I. Introduction224
- II. Class I POU Domain Proteins225
- III. Class III POU Domain Proteins228
- IV. Class IV POU Domain Proteins239
- V. Discussion247
- References251
- Chapter 8. DNA Repair and Chromatin Structure in Genetic Diseases257
- I. Introduction258
- II. DNA Endonuclease Complexes260
- III. Activity of Endonuclease Complexes on Damaged Naked Dna263
- IV. DNA Damage-Recognition Proteins277
- V. Activity of Endonuclease Complexes on Damaged Nucleosomal DNA281
- VI. Correction of the XP Repair Defect at the Cellular and Nucleosomal Levels290
- VII. Mechanism of Location of Sites of Damage291
- VIII. Models for the Repair Defect in XPA Cells299
- IX. Conclusions300
- References302
- Chapter 9. Recombinational DNA Repair in Bacteria and the RecA Protein311
- I. Recombinational DNA Repair in Bacteria312
- II. The Reca Protein331
- III. Summary and Prospects357
- References357
- Chapter 10. A Survey of the Sequence-Specific Interaction of Damaging Agents with DNA: Emphasis on A367
- I. Introduction and Short History368
- II. Methods for Determining the Sequence Specificity of DNA-Damaging Agents370
- III. Survey of the Sequence Specificity of DNA-Damaging Agents377
- IV. Sequence Specificity Issues402
- V. Summary and Future Prospects405
- References407
- Index417
Key Features
* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology
* Features contributions from leaders in their fields
* Contains abundant references
* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology
* Features contributions from leaders in their fields
* Contains abundant references