Progress in Nucleic Acid Research and Molecular Biology
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Table of contents
- Cover
- Contentsvii
- Chapter 1. ATP-Dependent Restriction Enzymes1
- I. Introduction2
- II. Classification of Restriction–Modification Systems3
- III. Type I Restriction–Modification Enzymes8
- IV. Type III Restriction–Modification Enzymes31
- V. Biological and Evolutionary Significance of Restriction–Modification Systems50
- References55
- Chapter 2. DNA Polymerase of the T4-Related Bacteriophages65
- I. Introduction66
- II. T4 as an Experimental System for Studies of DNA Replication67
- III. Biological Properties of T4 DNA Polymerase72
- IV. Structure of gp4383
- V. Perspectives and Concluding Remarks89
- References91
- Chapter 3. The Peripheral Myelin Protein 22 and Epithelial Membrane Protein Family97
- I. Introduction98
- II. Cloning and Expression of PMP22 and EMPs99
- III. Structure of PMP22 and EMPs103
- IV. Genomic Structure and Regulation107
- V. Putative Functions of PMP22 and EMPs in Cell Growth and Differentiation111
- VI. PMP22 in Myelination and Disease113
- VII. Summary122
- References122
- Chapter 4.Translational Frameshifting: Implications for the Mechanism of Translational Frame Mainten131
- I. Introduction132
- II. Nature of Translational Errors133
- III. Translational Accuracy and Inaccuracy134
- IV. Genetics of Translational Frame Maintenance135
- V. Programmed Alternative Decoding149
- VI. A Synthesis of Alternative Decoding Events162
- VII. Summary165
- References166
- Chapter 5. Syndromes Associated with Homo sapiens Pol II Regulatory Genes171
- I. Introduction172
- II. Background172
- III. Syndromes Associated with Regulators of Transcription178
- IV. Perspective209
- References210
- Chapter 6. Topoisomerase II as a Target for Anticancer Drugs: When Enzymes Stop Being Nice221
- I. Introduction222
- II. Type II Topoisomerases223
- III. Topoisomerase II Poisons229
- IV. Mechanism of Action of Topoisomerase II Poisons231
- V. Interactions between Topoisomerase II and PoisoningŽ Drugs236
- VI. The Positional Poison Model239
- VII. Mechanistic Basis for Altered Sensitivity to Topoisomerase II Poisons241
- VIII. Topoisomerase II Catalytic Inhibitors242
- IX. Conclusions and Perspectives244
- References245
- Chapter 7. The Biological Properties and Evolutionary Dynamics of Mammalian LINE-1 Retrotransposons255
- I. Introduction256
- II. Biological Properties of L1 Elements257
- III. History and Mechanisms of L1 Evolution279
- IV. Impact of L1 Elements of Mammals288
- References290
- Chapter 8.Regulation of the Mammalian Alcohol Dehydrogenase Genes295
- I. The ADH Gene Family: Overview296
- II. Class I ADH303
- III. Class II ADH323
- IV. Class III ADH325
- V. Class IV ADH328
- VI. Class V ADH331
- VII. Class VI ADH332
- VIII. Common Themes and Elements333
- References334
- Chapter 9. Transcriptional Regulation by Cyclic AMP-Responsive Factors343
- I. Introduction344
- II. A Multigene Family of cAMP-Responsive Transcription Factors345
- III. Mechanisms of Transcriptional Activation by CREM and CREB349
- IV. Modularity and Versatility of the CREM Gene354
- V. A Physiological Outlook at CREB and CREM Functions358
- VI. Conclusions and Perspectives366
- References366
- Index371
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes.
Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology.
Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.
Key Features
* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology
* Includes contributions from leaders in the field
* Contains abundant references
Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology.
Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.
Key Features
* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology
* Includes contributions from leaders in the field
* Contains abundant references