Progress in Nucleic Acid Research and Molecular Biology
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Table of contents
- Cover
- Contentsv
- Chapter 1. Cyclic Nucleotide Phosphodiesterases Relating Structure and Function1
- I. Introduction2
- II. Background3
- III. Classification3
- IV. Structural Features of PDEs5
- V. Features of Catalysis8
- VI. Mechanisms Utilized for Regulation of PDEs18
- VII. PDE Families20
- VIII. Concluding Remarks41
- References41
- Chapter 2. Thyroid Hormone Regulation of Apoptotic Tissue Remodeling: Implications from Molecular An53
- I. Introduction54
- II. Thyroid Hormone and Vertebrate Development55
- III. Mechanism of Thyroid Hormone Action58
- IV. Thyroid Hormone-Dependent Morphological and Cellular Changes during Intestinal Remodeling70
- V. TR Expression and Function during Intestinal Remodeling77
- VI. Thyroid Hormone Response Genes in the Intestine80
- VII. Functions of TH Response Genes Implication from Studies on Matrix Metalloproteinases84
- VIII. Conclusions and Prospects91
- References94
- Chapter 3. Role of S6 Phosphorylation and S6 Kinase in Cell Growth101
- I. 40S Ribosomal Protein S6103
- II. S6 Kinase108
- III. Downstream Effectors of S6K117
- IV. Physiological Importance119
- V. Future Perspectives122
- References123
- Chapter 4. Molecular Characterization of Monoamine Oxidases A and B129
- I. Gene Cloning and Structure131
- II. Functional Regions of MAO B135
- III. Tissue and Cell Distribution149
- IV. Physiological Functions150
- V. Future Perspectives152
- References152
- Chapter 5. Squalene Synthase: Structure and Regulation157
- I. History of SQS Research159
- II. Purification of Rat SQS161
- III. Intracellular Location of SQS163
- IV. Isolation of Mammalian SQS Cdna Clones164
- V. Reaction Mechanism166
- VI. Identification of Functional Domains in SQS166
- VII. SQS Genes and mRNAs174
- VIII. SQS Regulation177
- References191
- Chapter 6. Yeast Chromatin Structure and Regulation of GAL Gene Expression197
- I. Yeast Genomic-Level Chromatin Structure198
- II. Yeast GAL Gene Regulation214
- III. GAL Gene-Specific Chromatin Structure223
- References254
- Chapter 7. A Coordinated Interplay Proteins with Multiple Functions in Dna Replication, Dna Repair,261
- I. DNA Polymerases263
- II. DNA Polymerase Accessory Proteins279
- III. Transcription Factors and Their Role in Activation of Dna Replication286
- IV. Perspectives and Conclusions291
- References292
- Chapter 8. Signal Transduction Pathways and the Modification of Chromatin Structure299
- I. Chromatin Organization300
- II. Core Histone Tails302
- III. Transcriptionally Active Chromatin303
- IV. Histone Variants and Modifications305
- V. Karyoskeleton and Organization of Chromatin326
- VI. Karyoskeleton and Transcription Factories327
- VII. Transcriptionally Active Chromatin and the Karyoskeleton327
- VIII. Transcription Factors and the Karyoskeleton328
- IX. Hats, Hdacs, and the Karyoskeleton329
- X. Mechanical Signaling Pathways and Organization of Nuclear DNA329
- XI. Future Directions331
- References332
- Chapter 9. RGS Proteins Lessons from the RGS9 Subfamily341
- I. Discovery of Photoreceptor GAP and RGS Protein Family342
- II. Some Outstanding Problems in RGS Protein Function and Structure344
- III. Contributions to Solving These Problems from RGS9 and Its Subfamily of RGS Proteins349
- IV. Future Prospects355
- References356
- Chapter 10. Regulation of Mammalian Cell Membrane Biosynthesis361
- I. Introduction362
- II. Regulation of Phosphatidylcholine Biosynthesis364
- III. Regulation of Phosphatidylethanolamine Biosynthesis374
- IV. Regulation of Phosphatidylinositol Biosynthesis376
- V. Regulation of a Phosphatidylserine Biosynthesis379
- VI. Cells Maintain a Constant Amount of Membrane Phospholipid380
- VII. Inhibition of Phospatidylcholine Biosynthesis Induces Apoptosis382
- VIII. Future Directions386
- References388
- Index395
Provides a forum for discussion of new discoveries, approaches, and idea in molecular biology. Contains contributions from leaders in their fields and abundant references.
Key Features
* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology
* Features contributions from leaders in their fields
* Contains abundant references
Key Features
* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology
* Features contributions from leaders in their fields
* Contains abundant references