Progress in Nucleic Acid Research and Molecular Biology
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Table of contents
- Cover
- Contentsv
- Some Articles Planned for Future Volumesix
- Chapter 1. T7 RNA Polymerase1
- I. Introduction2
- II. Structure and Structure-Function Relationships2
- III. Sequence and Structural Similarities, Phylogeny, and Origins11
- IV. The Transcription Reaction13
- V. Regulation29
- VI. DNA Replication32
- VII. T7 RNAP„Applications33
- References35
- Chapter 2. DNA Supercoiling and Transcription Control: A Model from the Study of Suppression of the43
- DNA Supercoiling and Gene Expression Regulation44
- II. Suppression of leu-500 Mutation in Salmonella typhimurium topA Mutants: An Old Phenomenon Revisi48
- III. A New Explanation for the Old Phenomenon, the Suppression of leu-500 Mutation in Salmonella typ54
- IV. The Promoter Relay in the ilvIH–leuO–leuABCD Gene Cluster Is a Bacterial Stress Response56
- V. Conlcuding Remarks61
- VI. Perspective62
- References63
- Chapter 3. Protein Tyrosyl Phosphatases in T Cell Activation: Implication for Human Immunodeficiency69
- I. Structure and Function of Protein Tyrosine Phosphatases in T Cells70
- II. Regulation of HIV-1 Replication by PTPs84
- III. Conclusions and Perspectives96
- References97
- Chapter 4. Dynamic Interplay between O-Glycosylation and O-Phosphorylation of Nucleocytoplasmic Prot107
- I. Dynamic Interplay between O-Glycosylation and O-Phosphorylation of Nucleocytoplasmic Proteins108
- II. Future Directions126
- References127
- Chapter 5. Fidelity Mechanisms of DNA Polymerase B137
- I. Introduction138
- II. The DNA Polymerase Reaction Mechanism139
- III. DNA Polymerases Function in Nucleotide Selectivity140
- IV. Inherent Characteristics of Error Production by DNA Polymerase B141
- V. Overview of DNA Polymerase B Fidelity Mechanisms142
- VI. Nucleotide Selectivity during Binding of the Nucleotide Substrate to Pol B144
- VII. Nucleotide Selectivity during Phosphodiester Bond Formation152
- VIII. Precise Positioning of DNA Is Important for Fidelity158
- IX. Positioning of Active Site Residues Is Critical for Fidelity162
- X. Perspectives and Concluding Remarks164
- References165
- Chapter 6. Mechanistic Studies of Protein Tyrosine Phosphatases171
- I. Classification of the PTP Superfamily173
- II. Functional Roles of PTPs in Cellular Signaling177
- III. Structural Features of PTPs178
- IV. Mechanistic Studies of the PTP-Catalyzed Reaction182
- V. A Conserved Mechanism for PTP Satalysis198
- VI. The Nature of the Transition State of the Phosphate Monoester Hydrolysis199
- VII. Concluding Remarks and Future Perspectives209
- References210
- Chapter 7. The CCR4–NOT Complex Plays Diverse Roles in mRNA Metabolism221
- I. Introduction222
- II. The CCR4–NOT Complexes and Their Constituents222
- III. Roles of the CCR4–NOT Complex in mRNA Metabolism234
- IV. CCR4–NOT Roles in Integrating Cell Signaling Pathways241
- V. Perspective243
- References245
- Chapter 8. Transcriptional Control of Multidrug Resistance in the Yeast Saccharomyces251
- I. Introduction251
- II. Positive Transcriptional Regulators253
- III. Negative Regulators263
- IV. Conclusions269
- References271
- Index281
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.
* Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology
* Includes contributions from the leaders in the field
* Has abundant references
* Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology
* Includes contributions from the leaders in the field
* Has abundant references