Progress in Nucleic Acid Research and Molecular Biology
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Table of contents
- Cover
- Contentsv
- Some Articles Planned for Future Volumesix
- Chapter 1. Fine Tuning the Transcriptional Regulation of the CXCL1 Chemokine .1
- I. Chemotactic Cytokines2
- II. Receptors of Chemokines5
- III. Chemokines in Wound Healing and Diseases7
- IV. Differential Expression of Chemokines10
- V. Transcriptional Regulation of CXC Chemokines11
- VI. Regulation of NF- kB Activation13
- VII. Role of CBP in CXCL1 Transcription18
- VIII. PARP as a Transcriptional Activator of the CXCL1 Gene20
- IX. CDP as a Transcriptional Repressor of the CXCL1 Gene23
- X. Reflection25
- XI. References26
- Chapter 2. Enzymes That Cleave and Religate DNA at High Temperature: The Same Story with Different A37
- I. Topoisomerases38
- II. Recombinases59
- III. Concluding Remarks73
- References74
- Chapter 3. Molecular Mimicry in the Decoding of Translational Stop Signals83
- I. Introduction84
- II. Atomic Level Structures of the Ribosome and Its Subunits85
- III. The Active Center of the Ribosome87
- IV. The Three-Dimensional Space of the Active Center90
- V. The Mimicry Complex in Termination94
- VI. The RF Structure: Does It Look Like a tRNA?99
- VII. The Paradox between the Structural and Functional Evidence for the Bacterial RF ‘‘Anticodon103
- VIII. Specific Interactions within the Bacterial Termination Complex106
- IX. The Termination Mechanism111
- X. Summary114
- References115
- Chapter 4. Phylogenetics and Functions of the Double-Stranded RNA-Binding Motif: A Genomic Survey123
- I. Introduction124
- II. Survey Methods125
- III. dsRBM Occurrence, Frequency, and Conservation126
- IV. Domain Structures of dsRBM Proteins129
- V. dsRBM Protein Families in Five Type Species131
- VI. dsRBMs in Other Taxa146
- VII. Concluding Remarks148
- References152
- Chapter 5. Mending the Break: Two DNA Double-Strand Break Repair Machines in Eukaryotes159
- I. Introduction160
- II. Biological Relevance of the DSB161
- III. Genetic Pathways for Homologous Recombination162
- IV. Recombination Genes: the RAD52 Epistasis Group166
- V. General Introduction to NHEJ178
- VI. Mechanisms and Function of NHEJ in Eukaryotes179
- References191
- Chapter 6. The Yeast and Plant Plasma Membrane H+ Pump ATPase: Divergent Regulation for the Same Fun203
- I. Introduction204
- II. PM H+ -ATPase Gene Organization and Expression205
- III. Structure and Activity206
- IV. Functions209
- V. Translational Regulation212
- VI. Posttranslational Regulation212
- VII. Trafficking218
- VIII. General Conclusions225
- References228
- Chapter 7. The Genes Encoding Human Protein Kinase CK2 and Their Functional Links239
- I. Introduction240
- II. Protein Kinase CK2241
- III. The Human Protein Kinase CK2 Genes245
- IV. Expression of Human CK2 Genes250
- V. Functional Links of CK2 Genes262
- References268
- Chapter 8. Heterochromatin, Position Effects, and the Genetic Dissection of Chromatin275
- I. Introduction276
- II. Heterochromatin and Gene Silencing278
- III. Heterochromatin and Gene Activation278
- IV. Genetic Strategies for Dissection of Heterochromatin279
- V. cis-Spreading trans-Inactivation, and Heterochromatic Associations281
- VI. Molecular Composition of Heterochromatin and the Regulation of Heterochromatin Silencing283
- VII. Setting Up Heterochromatin and Euchromatin Domains291
- VIII. Summary and Future Directions292
- References293
- Index301
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.
* Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology
* Includes contributions from the leaders in the field
* Has abundant references
* Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology
* Includes contributions from the leaders in the field
* Has abundant references