Proteins: Analysis and Design
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Table of contents
- Contentsvii
- Dedicationv
- Contributorsix
- Prefacexi
- Introduction1
- Chapter 1. Current Problems and Technical Solutions in Protein Biochemistry3
- I. Introduction4
- II. Early Events in Signaling by Interferons: From Membrane Receptor to Induced Genes6
- III. Detection of Systems Components8
- IV. Identification of Components of Complex Systems17
- V. Analysis of Regulatory Modifications of Components of Complex Systems50
- VI. Analysis of Protein: Ligand Complexes76
- VII. Conclusion93
- References94
- Chapter 2. Posttranslational Modifications121
- I. Introduction121
- II. Types of Posttranslational Derivatives125
- III. Types of Posttranslational Reactions: How Modifications Are Made159
- IV. Biological Functions of Posttranslational Modifications: Why Modifications Are Made175
- References192
- Chapter 3. Design and Use of Synthetic Peptides as Biological Models207
- I. Peptides as Structural Models of Proteins208
- II. Cell/Peptide Interactions219
- III. Protein/Peptide Interactions228
- IV. Peptides and Modulation of T-Cell Behavior236
- V. Enzyme/Peptide Interactions: Peptides as Enzyme Substrates240
- VI. Summary243
- References243
- Chapter 4. Site-Directed Mutagenesis and Protein Engineering259
- I. Introduction259
- II. Why Alter Proteins?260
- III. Techniques for Oligonucleotide-Directed Mutagenesis261
- IV. Strategies for Engineering Proteins272
- V. Case Studies: Introduction of Function by Site-Directed Mutagenesis291
- VI. Conclusion302
- References303
- Chapter 5. De Novo Design of Protein Structure and Function313
- I. Introduction and Overview313
- II. De Novo Design of Structure314
- III. Characterizing the Design319
- IV. Selected Examples of Designed Proteins320
- V. De Novo Design of Function331
- VI. Design of Catalytic Proteins344
- VII. Summary and Future Directions348
- References348
- Index355
- Color Plate Section363
Proteins: Analysis and Design focuses solely on individual experimental approaches, rather than on specific classes of proteins. The book provides insight into the important issues in protein science and how one can cope with them. These include all issues which explore the detailed relationship of protein structure to function.
Key Features:
* Provides problems and technical solutions
* Includes posttranslational modifications
* Uses synthetic peptides as biological models
* Details mutagenesis and protein engineering
* Covers design of protein structure and function
Key Features:
* Provides problems and technical solutions
* Includes posttranslational modifications
* Uses synthetic peptides as biological models
* Details mutagenesis and protein engineering
* Covers design of protein structure and function