Elsevier S & T

Proteins in Eukaryotic Transcription

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Table of contents
  • Proteins in Eukaryotic Transcriptioniii
  • Copyright Pageiv
  • CONTENTSv
  • PREFACEix
  • Chapter 1. Structure and Function of RNA Polymerase II1
  • I. Perspective1
  • II. Structure of RNA Polymerase II3
  • III. Function of RNA Polymerase II13
  • IV. Comparison with Other Polymerases27
  • V. Conclusions30
  • References31
  • Chapter 2. The Mediator Complex43
  • I. Summary43
  • II. Saccharomyces cerevisiae Mediator43
  • III. Mediator Complexes in Higher Eukaryotes52
  • IV. Mechanism of Transcriptional Activation55
  • V. Concluding Remarks62
  • References62
  • Chapter 3. Structure and Function of the TFIID Complex67
  • I. TFIID and Transcription Initiation67
  • II. TFIID Components and Structure68
  • III. TFIID Functions76
  • IV. The Requirement for TFIID In Vivo82
  • V. Regulation of TFIID84
  • VI. The TFIID-Chromatin Connection85
  • VII. Future Questions87
  • References87
  • Chapter 4.Tetratricopeptide Repeats of TFC4 and a Limiting Step in the Assembly of the Initiation Fa93
  • I. Introduction93
  • II. Brf1-TFIIIC: A Limiting Interaction in Preinitiation Complex Assembly95
  • III. Brf1-Tfc4 Interactions97
  • IV. Bdp1-Tfc4 Interactions105
  • V. Ligand Binding by TPR Arrays in Tfc4107
  • VI. Ordered Binding of TFIIIB Subunits to TFIIIC-DNA and Dynamic Interactions with Tfc4111
  • VII. Tfc4 and Other Pol III Factors114
  • VIII. Conclusion115
  • References116
  • Chapter 5. Mechanism of RNA Polymerase I Transcription123
  • I. Introduction123
  • II. Ribosomal DNA Gene Structure124
  • III. Species-Specificity of Ribosomal RNA Transcription127
  • IV. Factors Involved in Ribosomal RNA Transcription128
  • V. Assembly of an RNA Polymerase I Initiation Complex in Vertebrates136
  • VI. Factors Required for RNA Polymerase I Transcription in Yeast138
  • VII. Regulatory Mechanisms140
  • VIII. Chromatin and RNA Polymerase I Transcription147
  • IX. Conclusions149
  • Acknowledgments149
  • References149
  • Chapter 6. Functional Properties of ATP-Dependent Chromatin Remodeling Enzymes157
  • I. Introduction157
  • II. History of Nucleosome-Remodeling Complexes158
  • III. Requirements for Nucleosome-Remodeling Enzymes163
  • IV. Mechanisms of ATP-Dependent Chromatin Remodeling168
  • V. Initiation of ATP-Dependent Chromatin Remodeling174
  • VI. Conclusions176
  • Acknowledgments177
  • References177
  • Chapter 7. Histone Acetyltransferase Proteins Contribute to Transcriptional Processes at Multiple Le181
  • I. Introduction181
  • II. HATs and HAT Complexes: New Insights into HAT Regulation and Effects on Transcription182
  • III. HAT Complexes Functionally Interact with Chromatin- Remodeling Complexes and Influence Transcri187
  • IV. HAT Proteins Function in Regulating Transcriptional Elongation192
  • V. The Histone Code: Insights into Epigenetic Regulation of Transcription194
  • VI. HATs: New Insight into Transcription and DNA Repair195
  • VII. Conclusion and Perspectives196
  • Acknowledgments196
  • References197
  • Chapter 8. Posttranslational Modifications of Histones by Methylation201
  • I. Introduction201
  • II. Lysine Methyltransferases207
  • III. Arginine Methyltransferases215
  • IV. Epilogue218
  • References219
  • Author Index223
  • Subject Index245
Book details
  • Vendor Elsevier S & T
  • SKU 9780120342679
  • ISBN-13 9780080522418

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Protein Transcription is a key element of cellular and organ regulation. This volume covers structure and function of all major elements associated with transcription.

*Mechanism of RNA polymerase I Transcription
*Structure and function of RNA Polymerase II
*Structure and function of the TFIID complex
*Functional properties of Chromatin Remodeling Enzymes
*Posttranslational modification