Elsevier S & T

Quantitative Functional Brain Imaging with Positron Emission Tomography

Carson, Richard E.; Herscovitch, Peter; Daube-Witherspoon, Margaret E.

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Table of contents

Contentsv
Contributorsxi
Prefacexix
Acknowledgmentsxxi
SECTION I: DATA ACQUISITION AND QUANTIFICATION1
Chapter 1. Brain Imaging in Small Animals Using MicroPET3
Chapter 2. Design of a High-Resolution, High-Sensitivity PET Camera for Human Brains and Small Anima11
Chapter 3. The Road to Simultaneous PET/MR Images of the Brain19
Chapter 4. Brain PET Studies with a High Sensitivity Fully Three-Dimensional Tomograph25
Chapter 5. Emission-Transmission Realignment Using a Simultaneous Emission-Transmission Postinjectio33
Chapter 6. Optimization of H2O Dose and Data Acquisition in Three-Dimensional Activation Studies Usi41
Chapter 7. Parametric Image Reconstruction Using Spectral Analysis of (Rebinned) Three-Dimensional P45
Chapter 8. Multislice PET Quantitation Using Three-Dimensional Volumes of Interest51
Chapter 9. Absolute PET Quantification with Correction for Partial Volume Effects within Cerebral St59
Chapter 10. Pixel- versus Region-Based Partial Volume Correction in PET67
Chapter 11. Impact of Partial Volume Correction on Kinetic Parameters: Preliminary Experience in Pat77
SECTION II: IMAGE PROCESSING83
Chapter 12. Performance Characterization of a Feature-Matching Axial Smoothing Method for Brain PET85
Chapter 13. Registration of Multitracer PET Data91
Chapter 14. Multimodality Brain Image Registration Using a Three-Dimensional Photogrammetrically Der99
Chapter 15. Classification of Dynamic PET Images Using a Priori Kinetic Factors107
Chapter 16. Methodology for Statistical Parametric Mapping of [18F]Fluorodopa Uptake Rate Using Thre117
Chapter 17. Use of Nonlinear Kernel Analysis to Evaluate "Badness-of-Fit" of the Transformation of P125
Chapter 18. Data Extraction from Brain PET Images Using Three-Dimensional Stereotactic Surface Proje133
Chapter 19. A Method for Surface-Based Quantification of Functional Data from the Human Cortex139
SECTION III: APPLICATIONS143
Chapter 20. Sequential Experimental PET: Voxel-Based Analysis Reveals Spatiotemporal Dynamics of Per145
Chapter 21. Estimation of Ischemic Cerebral Blood Flow Using [15O]Water and PET without Arterial Blo151
Chapter 22. Suitability of [15O]Water and PET to Detect Activation-Induced Cerebral Blood Flow Chang155
Chapter 23. Magnetic Resonance Imaging-Guided Language Activation PET in Patients: Technical Aspects159
Chapter 24. Brain Networks of Motor Behavior Assessed by Principal Component Analysis165
Chapter 25. Frequency-Dependent Changes in Cerebral Metabolic Rate of Oxygen during Activation of Hu173
Chapter 26. Validation of an [18F]Fluorodeoxyglucose–PET Protocol in Conscious Vervet Monkey177
Chapter 27. Comparison of Ketamine / Midazolam versus Pentobarbital on [18F]Fluorodopa PET Kinetics183
Chapter 28. Metabolism of [18F]Fluorodopa in Pig Brain Estimated by PET187
Chapter 29. Use of Two- and Three-Dimensional PET and [11C](R)-PK11195 to Image Focal and Regional B195
Chapter 30. Noninvasive Imaging of Serotonin Synthesis Rate Using PET and α-Methyltryptophan in Aut201
Chapter 31. Brain Mapping of the Effects of Aging on Histamine H1 Receptors in Humans: A PET Study w207
SECTION IV: STATISTICAL ANALYSIS215
Chapter 32. PET Analysis Using a Variance Stabilizing Transform217
Chapter 33. Error and t Images Depend on ANOVA Design and Anatomical Standardization in PET Activati223
Chapter 34. Calculation of the Probability That an Activation Site Has Occurred by Chance229
Chapter 35. Multifiltering Signal Detection and Statistical Power in Brain Activation Studies237
Chapter 36. Measuring Activation Pattern Reproducibility Using Resampling Techniques241
Chapter 37. Reproducibility of Regional Metabolic Covariance Patterns: Comparison of Four Population247
Chapter 38. On the Detection of Activation Patterns Using Principal Components Analysis253
SECTION V: TRACER DEVELOPMENT259
Chapter 39. One for All or One for Each? Matching Radiotracers and Regional Brain Pharmacokinetics261
Chapter 40. Use of Information Technology in the Search for New PET Tracers267
Chapter 41. Statistical Power Analysis of in Vivo Studies in the Rat Brain Using PET Radiotracers273
Chapter 42. A Human Liver Model of Metabolism as a Tool in the Identification of Potential PET Radio279
Chapter 43. HPLC Analysis of the Metabolism of 6-[18F]Fluoro-L-DOPA in the Brain of Neonatal Pigs285
Chapter 44. Characterization of the Radiolabeled Metabolites of [18F]Altanserin: Implications for Ki293
Chapter 45. Preliminary Evaluation of the Glycine Site Antagonists [11C]L 703,717 and [3H]MDL 105,51299
SECTION VI: PARAMETER ESTIMATION305
Chapter 46. Evaluation of the Contribution of Protocol Design to Model Parameter Uncertainty307
Chapter 47. An Assessment of Optimal Image Sampling Schedule Design in Dynamic PET–FDG Studies315
Chapter 48. Simultaneous Extraction of Physiological and Input Function Parameters from PET Measurem321
Chapter 49. Suppression of Noise Artifacts in Spectral Analysis of Dynamic PET Data329
Chapter 50. Contraints in Spectral Analysis335
Chapter 51. Generalized Linear Least-Squares Modeling Algorithm for Optimally Sampled PET Image Data339
Chapter 52. Parametric Image Generation with Neural Networks347
Chapter 53. Kinetic Modeling: Achieving Computer Platform Independence with Java353
SECTION VII: KINETIC MODELING357
Chapter 54. Temporally Overlapping Dual-Tracer PET Studies359
Chapter 55. Simultaneous Estimation of Perfusion (K1) and Vascular (V0) Responses in [15O]Water PET367
Chapter 56. Enhancement of the Signal-to-Noise Ratio in [15O]Water Bolus PET Activation Studies Usin371
Chapter 57. Neutral Amino Acids Influence [18F]Fluorodopa Quantification379
Chapter 58. Imaging of the Dopamine Presynaptic System by PET: 6-[18F]Fluoro-L-DOPA versus 6-[18F]Fl387
Chapter 59. Quantitative Measurement of Acetylcholinesterase Activity in Living Human Brain Using a393
Chapter 60. Parametric Imaging of Ligand-Receptor Interactions Using a Reference Tissue Model and Cl401
Chapter 61. Limitation of Binding Potential as a Measure of Receptor Function: A Two-Point Correctio407
Chapter 62. Estimation of Nonspecific Binding of [18F]Setoperone, a 5HT2A Receptor PET Radioligand,415
Chapter 63. Estimation of Binding Potential for the 5HT2 Receptor Ligand [18F]Setoperone by a Noninv421
Chapter 64. [18F]Altanserin PET Studies of Serotonin-2A Binding: Examination of Nonspecific Componen427
Chapter 65. Characteristics of Neurotransmitter Competition Studies Using Constant Infusion of Trace435
Chapter 66. PET Measurement of Endogenous Neurotransmitter Activity Using High and Low Affinity Radi441
Chapter 67. Measuring Neurotransmitter Release withh PET: Methodological Issues449
Chapter 68. Imaging Receptor Occupancy by Endogenous Transmitters in Humans455
Chapter 69. Quantification of Extracellular Dopamine Release in Schizophrenia and Cocaine Use by Mea463
SECTION VIII: BRAINPET97 DISCUSSION469
Index497
Color Plate SectionColor Plate-1

Book details

Vendor Elsevier S & T
SKU 9780121613402
ISBN-13 9780080540115
Author Carson, Richard E.; Herscovitch, Peter; Daube-Witherspoon, Margaret E.
Category Medical
Subject Diagnostic Imaging

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This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain.

Key Features
* Authored by international authorities in PET
* Provides the latest up-to-date techniques and applications
* Covers all fundamental disciplines of PET in one volume
* A comprehensive resource for students, clinicians, and new PET researchers

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