Elsevier S & T

Quinones and Quinone Enzymes, Part B

Sies, Helmut

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Table of contents
  • Table of Contentsvii
  • Contributors to Volume 382xi
  • Prefacexv
  • Volumes in Seriesxvii
  • Section I: Mitochondrial Ubiquinone and Reductases1
  • Chapter 1. Mitochondrial Quinone Reductases: Complex I3
  • Chapter 2. Q-cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes21
  • Chapter 3. Targeting Coenzyme Q Derivatives to Mitochondria45
  • Chapter 4. The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia67
  • Chapter 5. Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency81
  • Chapter 6. Coenzyme Q Cytoprotective Mechanisms89
  • Chapter 7. Dietary Coenzyme Q10 and Mitochondrial Status105
  • Section II: Anticancer Quinones and Quinone Oxidoreductases113
  • Chapter 8. NAD(P)H: Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics115
  • Chapter 9. Structure and Mechanism of NAD[P]H: Quinone Acceptor Oxidoreductases (NQO)144
  • Chapter 10. Diaziridinylbenzoquinones174
  • Chapter 11. Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications194
  • Chapter 12. Bioactivation and Resistance to Mitomycin C221
  • Chapter 13. NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase234
  • Chapter 14. The ‘‘Prochaska’’ Microtiter Plate Bioassay for Inducers of NQO1243
  • Chapter 15. Structure-Activity Relationships in Two-Electron Reduction of Quinones258
  • Chapter 16. p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1278
  • Chapter 17. The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerati293
  • Chapter 18. Induction of NQO1 in Cancer Cells320
  • Section III: Quinone Reductases: Chemoprevention and Nutrition353
  • Chapter 19. Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection Against Toxicity of E355
  • Chapter 20. Activation and Detoxification of Naphthoquinones by NAD(P)H:Quinone Oxidoreductase364
  • Chapter 21. Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens380
  • Chapter 22. Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 En414
  • Chapter 23. Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)423
  • Chapter 24. Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An O449
  • Chapter 25. Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products from Dietary Broc457
  • Section IV: Quinones and Age-Related Diseases471
  • Chapter 26. Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases473
  • Chapter 27. Neuroprotective Actions of Coenzyme Q10 in Parkinson’s Disease488
  • Author Index511
  • Subject Index561
Book details
  • Vendor Elsevier S & T
  • SKU 9780121827861
  • ISBN-13 9780080497204
  • Author Sies, Helmut
  • Category Science
  • Subject Research & Methodology

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Description eBook delivery & access Reviews
Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.

*Mitochondrial Ubiquinone and Reductases
*Anticancer Quinones and Quinone Oxido-Reductases
*Quininone Reductases: Chemoprevention, Nutrition
*Quinones and Age-Related Diseases