Rabies
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Table of contents
- Copyright Pageiv
- Contentsv
- Contributorsxi
- Forewordxiii
- Prefacexvii
- Chapter 1. History1
- I. Text1
- References21
- Chapter 2. Rabies Virus23
- I. Introduction23
- II. Rabies Virus Structure25
- III. Intracellular Life Cycle of Rabies Virus35
- IV. Genome Variability45
- V. Virus Spread46
- VI. Molecular Biology of Rabies Virus Proteins47
- References61
- Chapter 3. Molecular Epidemiology79
- I. Introduction79
- II. Methods and Definition of Terms81
- III. Insights: Aspects of Rabies Epidemiology and Pathogenesis Revealed by Molecular Methods of Epid98
- IV. Conclusions108
- References108
- Chapter 4. Epidemiology113
- I. Introductory Concepts114
- II. The Epidemiology of Human Rabies116
- III. Epidemiology of Rabies in Domestic Animals126
- IV. Epidemiology of Rabies in Wildlife135
- V. Epidemiology of Other Lyssaviruses145
- References149
- Chapter 5. Animal Rabies163
- I. Introduction163
- II. Host Range164
- III. Susceptibility and Transmission165
- IV. Clinical Course168
- V. Differential Diagnosis230
- VI. A Question of Immunity?173
- VII. Reservoirs and Other Lyssaviruses174
- VIII. Rabies in Domestic Animals177
- IX. Wildlife Reservoirs185
- X. Other Animals as Reservoirs201
- XI. Conclusions206
- References207
- Chapter 6. Human Disease219
- I. Introduction219
- II. Exposures and Incubation Period220
- III. Clinical Forms of Disease222
- IV. Investigations227
- V. Differential Diagnosis230
- VI. Therapy232
- VII. Recovery from Rabies232
- VIII. Rabies due to Other Lyssavirus Genotypes235
- References237
- Chapter 7. Pathogenesis245
- I. Introduction246
- II. Events at the Site of Exposure246
- III. Spread to the CNS252
- IV. Spread within the CNS253
- V. Spread from the CNS254
- VI. Animal Models of Rabies Virus Neurovirulence256
- VII. Rabies Virus Receptors260
- VIII. Brain Dysfunction in Rabies262
- IX. Recovery from Rabies and Chronic Rabies Virus Infection272
- X. Summary274
- References274
- Chapter 8. Pathology283
- I. Introduction283
- II. Histopathology of Rabies Encephalomyelitis284
- III. Involvement of the Peripheral Nervous System290
- IV. Involvement of Extraneural Organs292
- V. Pathology of Paralytic Rabies293
- VI. Ultrastructural Observations294
- VII. Conclusions302
- References303
- Chapter 9. Diagnostic Evaluation307
- I. Introduction308
- II. Postmortem Diagnosis of Rabies in Animals309
- III. Virus Isolation322
- IV. Detection of Viral RNA by Molecular Methods323
- V. Diagnosis of Rabies in Humans337
- VI. Rabies Antibody Assays342
- References344
- Chapter 10. Immunology351
- I. Introduction351
- II. Molecular Components of a Specific Immune Response352
- III. Immune Responses during Rabies Virus Infection353
- IV. Immunologic Basis for Postexposure Vaccination Efficiency361
- V. Conclusions364
- References365
- Chapter 11. Vaccines371
- I. Human Rabies Vaccines372
- II. Rabies Vaccines for Domestic Animals378
- III. The Next Generation of Rabies Vaccines385
- References392
- Chapter 12. Public Health Management of Humans at Risk401
- I. Introduction401
- II. Preexposure Vaccination404
- III. Postexposure Treatment409
- IV. Travel to Developing Countries417
- V. Adverse Reactions to Cell-Culture Vaccines419
- VI. Interchangeability of Vaccines419
- VII. Large-Scale Human Exposures420
- VIII. Rabies Vaccination of Animals420
- IX. Postexposure Treatment in Developing Countries421
- References423
- Chapter 13. Control of Dog Rabies429
- I. Introduction429
- II. History430
- III. Dog Accessibility: A New Term in Canine Rabies Control435
- IV. Present Approaches to Dog Rabies Control437
- V. Significance of Public Awareness and Interdisciplinary Collaboration439
- VI. Research on Oral Vaccination440
- VII. Summary441
- References442
- Chapter 14. Rabies Control in Wildlife445
- I. The Concept of Controlling Rabies in Wildlife446
- II. Chiropteran Rabies Control447
- III. Initiation of Wildlife Rabies Control Programs447
- IV. Diagnosis of Suspect Wildlife449
- V. Animal Population Reduction: The First Call for Control449
- VI. Vector Species Biology, Epidemiology, and Genetics450
- VII. Transportation of Wildlife451
- VIII. Oral Rabies Vaccine Development451
- IX. Vaccine Bait Development451
- X. Biomarkers452
- XI. ORV Initiation454
- XII. Importance of the Home Range of Vector Species in Bait Distribution455
- XIII. Large-Scale Vaccine Bait Distribution Technology456
- XIV. Postdrop Surveillance of Target Species458
- XV. Vaccine Baiting Costs459
- XVI. Vaccine Baiting Efficiency and Cost Reduction460
- XVII. Baiting Success Guidelines461
- XVIII. Modeling463
- XIX. Program Perpetuation464
- References465
- Chapter 15. Future Developments and Challenges473
- I. Introduction473
- II. Pathogenesis474
- III. Epidemiology and Molecular Epidemiology474
- IV. Prevention of Human Rabies and Control of Animal Rabies475
- V. Diagnosis and Therapy of Human Disease477
- VI. Summary477
- References478
- Index481
Rabies offers a complete account of one of the oldest known diseases threatening public health today. Unlike most research-oriented descriptions of rabies, this book provides a narrative about the disease and its etiologic agent, encompassing the historical background to recent developments. The emphasis on the basic biology and molecular virology of the disease is intended to convey an understanding of the underlying mechanisms involved in the disease - essential information for diagnosis and prevention strategies. Current methods used in defining geographic origins and animal species of rabies viruses in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. The latest approved methods for controlling rabies in wildlife species are also covered. This account of rabies will interest clinicians, public health advisors, epidemiologists, research scientists, and anyone involved in diagnosing, treating, controlling, and preventing this disease.
Key Features
* A history of rabies from antiquity to the modern era
* Basic biology and molecular virology
* Epidemiological aspects
* Pathogenesis and pathology of the disease
* Clinical manifestations and diagnostic evaluation in humans and animals
* Preventive measures in humans and animals
Key Features
* A history of rabies from antiquity to the modern era
* Basic biology and molecular virology
* Epidemiological aspects
* Pathogenesis and pathology of the disease
* Clinical manifestations and diagnostic evaluation in humans and animals
* Preventive measures in humans and animals