Rabies: Scientific Basis of the Disease and Its Management
Regular price
61.000 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Copyright pageiv
- Contentsv
- Forewordx
- Prefacexvii
- Contributorsxviii
- Chapter 1 The History of Rabies1
- 1 Introduction1
- 2 Remedies for dog rabies from the early and middle ages to the 18th century2
- 3 Rabies in the New World6
- 4 The early role of wild animals in the spread of rabies7
- 5 Development of the first-generation rabies vaccine11
- References19
- Chapter 2 Rabies Virus23
- 1 Introduction23
- 2 Rabies virus structure24
- 3 Rabies virus replication29
- 4 Life cycle of rabies virus infection33
- 5 Virus cell-to-cell spread – perpetuating the virus life cycle41
- 6 Structure of rabies virus proteins in relation to function42
- References56
- Chapter 3 Molecular Epidemiology69
- 1 Introduction69
- 2 Methods and definition of terms70
- 3 Viral taxonomy96
- 4 Aspects of rabies pathogenesis and evolution revealed by molecular epidemiology110
- 5 Conclusions and future trends114
- Acknowledgments115
- References115
- Chapter 4 Epidemiology123
- 1 Introduction to concepts123
- 2 The epidemiology of human rabies129
- 3 Routes of rabies virus transmission to humans143
- 4 Risk and prevention of rabies following an exposure144
- 5 Epidemiology of rabies in mammalian populations147
- 6 Dissemination of canine rabies and evidence for periodic cycles155
- 7 Cross-species transmission (spillover) of rabies virus157
- 8 Spatial spread and epidemiology of wildlife rabies166
- 9 Control of rabies directed toward mammalian reservoir hosts172
- References180
- Chapter 5 Rabies in Terrestrial Animals201
- 1 Introduction201
- 2 Host range and susceptibility203
- 3 Transmission210
- 4 Clinical course211
- 5 Differential diagnosis214
- 6 Viral excretion and public health implications214
- 7 Reservoirs and other lyssaviruses216
- 8 Rabies in domestic animals216
- 9 Wildlife reservoirs226
- 10 Other animals as reservoirs or simply spillover hosts?242
- 11 Conclusions245
- References246
- Chapter 6 Bat Rabies259
- 1 Introduction – general considerations on bat rabies259
- 2 Bat rabies in the New World261
- 3 Bat rabies in the Old World277
- References299
- Chapter 7 Human Disease309
- 1 Introduction309
- 2 Exposures, incubation period and prodromal symptoms309
- 3 Clinical forms of disease314
- 4 Investigations319
- 5 Differential diagnosis323
- 6 Therapy324
- 7 Recovery from rabies325
- 8 Rabies due to other Lyssavirus genotypes329
- References333
- Chapter 8 Pathogenesis341
- 1 Introduction341
- 2 Events at the site of exposure341
- 3 Spread to the CNS348
- 4 Spread within the CNS349
- 5 Spread from the CNS350
- 6 Animal models of rabies virus neurovirulence351
- 7 Rabies virus receptors354
- 8 Brain dysfunction in rabies356
- 9 Recovery from rabies and chronic rabies virus infection368
- 10 Summary371
- References372
- Chapter 9 Pathology383
- 1 Introduction383
- 2 Macroscopic findings383
- 3 Pathology in the central nervous system384
- 4 Pathology in the peripheral nervous system397
- 5 Pathology involving the eye and extraneural organs401
- 6 Summary and conclusions403
- References403
- Chapter 10 Diagnostic Evaluation411
- 1 Introduction411
- 2 Post-mortem diagnosis of rabies in animals413
- 3 Virus isolation429
- 4 Use of molecular methods to detect viral RNA430
- 5 Diagnosis of rabies in humans453
- 6 Rabies antibody assays459
- Acknowledgements462
- References462
- Chapter 11 Rabies Serology471
- 1 Introduction471
- 2 Investigative serology472
- 3 Serologic methods474
- 4 Choosing an assay480
- 5 Quality assurance measures483
- 6 Conclusions486
- References486
- Chapter 12 Immunology489
- 1 Introduction489
- 2 Molecular components of a specific immune response489
- 3 Immune responses during RABV infection491
- 4 Immunological basis for post-exposure vaccination efficiency498
- 5 Conclusions501
- References501
- Chapter 13 Human Rabies Vaccines505
- 1 Introduction505
- 2 Value of vaccination506
- 3 Nerve tissue vaccines508
- 4 Cell culture vaccines509
- 5 Conclusions513
- References513
- Chapter 14 Animal Vaccines517
- 1 Introduction517
- 2 Animal rabies vaccines517
- References527
- Chapter 15 Next Generation Rabies Vaccines531
- 1 Introduction531
- 2 Recombinant virus vaccines531
- 3 DNA-based rabies vaccines537
- 4 Oral rabies vaccines derived from plants539
- References540
- Chapter 16 Public Health Management of Humans at Risk545
- 1 Introduction545
- 2 Pre-exposure vaccination548
- 3 Post-exposure vaccination553
- 4 Adverse reactions to cell culture vaccines561
- 5 Interchangeability of vaccines561
- 6 Rabies in children562
- 7 Travel to canine rabies endemic countries563
- 8 Rabies control in developing countries564
- 9 Educational awareness565
- References566
- Chapter 17 Dog Rabies and its Control573
- 1 Introduction573
- 2 The burden of canine rabies573
- 3 Historical perspectives on dog rabies control576
- 4 Dog accessibility578
- 5 Vaccination coverage580
- 6 The epidemiological theory of dog rabies control582
- 7 Oral vaccination of dogs584
- 8 Age at first vaccination585
- 9 Dog rabies control in wildlife conservation586
- 10 Economics of dog vaccination for rabies control587
- 11 Dog population management588
- 12 Conclusion589
- Acknowledgements590
- References590
- Chapter 18 Rabies Control in Wild Carnivores595
- 1 Introduction595
- 2 Historical aspects of rabies control in wildlife595
- 3 The concept of controlling rabies in wildlife599
- 4 Initiation of wildlife rabies control programs600
- 5 Diagnosis of suspect wildlife602
- 6 Vector species biology in relation to rabies epidemiology602
- 7 Transportation of wildlife603
- 8 Point infection control: the first callfor control603
- 9 Bait development for delivery of oralrabies vaccine605
- 10 ORV initiation/considerations606
- 11 Importance of vector home range and density for vaccine bait distribution612
- 12 Large-scale vaccine bait distribution technology613
- 13 Surveillance prior to, during and after a rabies control program614
- 14 Vaccine baiting costs/benefits and costs of rabies control618
- 15 Vaccine baiting efficiency and baiting success guidelines619
- 16 Contingency planning621
- 17 Modeling621
- 18 Conclusion623
- References624
- Chapter 19 Future Developments and Challenges635
- 1 Introduction635
- 2 Pathogenesis635
- 3 Epidemiology636
- 4 Prevention of human rabies637
- 5 Diagnosis and therapy of human rabies638
- 6 Control of animal rabies639
- 7 Summary641
- References641
- Index645
- A645
- B646
- C647
- D648
- E649
- F650
- G650
- H651
- I651
- J652
- K652
- L652
- M653
- N654
- O654
- P655
- Q656
- R656
- S658
- T658
- U659
- V659
- W660
- Z660
Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes.
* Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow fever, dengue fever, or Japanese encephalitis
* More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year
* New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled
* Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed
* Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation
* Includes an increase in illustrations to more accurately represent this diseases’ unique horror
* Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow fever, dengue fever, or Japanese encephalitis
* More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year
* New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled
* Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed
* Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation
* Includes an increase in illustrations to more accurately represent this diseases’ unique horror