Radicals for Life: the various forms of nitric oxide: the various forms of nitric oxide

van Faassen, Ernst; Vanin, Anatoly

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Table of contents
  • Cover
  • Table of contentsvii
  • Forewordv
  • Part I: Introductory Overview1
  • Chapter 1. Nitric oxide radicals and their reactions3
  • REFERENCES13
  • Part II: DNIC: Physico-chemical Properties and Biological Activity17
  • Chapter 2. DNICs: physico-chemical properties and their observations in cells and tissues19
  • INTRODUCTION19
  • LOW-MOLECULAR-WEIGHT DNIC WITH THIOL-CONTAINING LIGANDS20
  • VIBRATION SPECTROSCOPY OF NITROSYL LIGANDS IN DNIC28
  • MOSSBAUER (γ-RESONANCE) PROPERTIES OF LOW-MOLECULAR DNICS WITH THIOL-CONTAINING LIGANDS31
  • DNIC WITH SULFIDE AND NEOCUPROINE ANIONIC LIGANDS34
  • PROTEIN-BOUND DNICS37
  • LABORATORY SYNTHESIS OF DNIC WITH LOW-MOLECULAR ANIONIC LIGANDS42
  • THE MECHANISM FOR ASSEMBLY OF DNIC WITH THIOL-CONTAINING LIGANDS44
  • STABILITY OF LOW-MOLECULAR-WEIGHT AND PROTEIN-BOUND DNICS IN ANAEROBIC OR AEROBIC SOLUTIONS47
  • GEOMETRIC STRUCTURE AND ELECTRONIC CONFIGURATION OF DNIC IN SOLUTION AND CRYSTALLINE STATE48
  • OBSERVATIONS OF DNICS IN CELLS AND TISSUES56
  • LOOSELY BOUND IRON PARTICIPATES IN THE FORMATION OF DNIC66
  • CONCLUDING REMARKS67
  • ACKNOWLEDGMENT67
  • REFERENCES67
  • Chapter 3. Hypotensive, vasodilatory and anti-aggregative properties of dinitrosyl-iron complexes75
  • HYPOTENSIVE ACTIVITY OF DNICS75
  • THE VASODILATORY ACTIVITY OF DNICS87
  • ROLE OF DNIC/ NITRIC OXIDE STORES IN PROTECTION AGAINST NITRIC OXIDE OVERPRODUCTION90
  • DNIC CAPACITY OF INHIBITING PLATELET AGGREGATION92
  • ACKNOWLEDGMENT94
  • REFERENCES94
  • Chapter 4. DNICs and intracellular iron: nitrogen monoxide (NO)-mediated iron release from cells is97
  • GENERAL INTRODUCTION: NITROGEN MONOXIDE IS A VITAL MESSENGER MOLECULE AND CYTOTOXIC EFFECTOR97
  • NITROGEN MONOXIDE FORMS INTRACELLULAR COMPLEXES WITH IRON97
  • CELLULAR IRON METABOLISM98
  • IRON TRANSPORT AND UPTAKE: TRANSFERRIN AND THE TRANSFERRIN RECEPTOR 1100
  • EFFECT OF NITROGEN MONOXIDE ON INTRACELLULAR IRON METABOLISM100
  • THE MECHANISM OF NITROGEN MONOXIDE-MEDIATED Fe RELEASE FROM CELLS102
  • NITROGEN MONOXIDE MEDIATES IRON EXPORT FROM CELLS BY THE GSH TRANSPORTER, MRP1105
  • BIOLOGICAL RELEVANCE OF NITROGEN MONOXIDE-MEDIATED TRANSPORT VIA MRP1106
  • CONCLUSIONS112
  • ACKNOWLEDGMENTS112
  • REFERENCES113
  • Chapter 5. Low-molecular dinitrosyl iron complexes can catalyze the degradation of active centers of119
  • ACKNOWLEDGMENT135
  • REFERENCES135
  • Chapter 6. Products of the reaction of cytosolic and mitochondrial aconitases with nitric oxide139
  • ACKNOWLEDGMENT144
  • REFERENCES144
  • Chapter 7. Harnessing toxic reactions to signal stress: reactions of nitric oxide with iron–sulfur147
  • INTRODUCTION147
  • DNICS AND NITRIC OXIDE TOXICITY149
  • SoxR AS A SENSOR OF OXIDATIVE STRESS OR NITRIC OXIDE149
  • REPAIR OF PROTEIN DNICs151
  • L-CYSTEINE RELEASES FERROUS IRON FROM THE PROTEIN-BOUND DNIC153
  • IRON–SULFUR CLUSTERS CAN BE RE-ASSEMBLED TO REPLACE DNIC153
  • NEW NITRIC OXIDE SIGNALING PATHWAYS VIA FeS CLUSTERS155
  • A MODEL FOR SoxR ACTIVATION IN RESPONSE TO MULTIPLE SIGNALS155
  • PERSPECTIVE156
  • ACKNOWLEDGMENTS157
  • REFERENCES157
  • Chapter 8. Nitric oxide and dinitrosyl iron complexes: roles in plant iron sensing and metabolism161
  • NITRIC OXIDE FUNCTIONS IN PLANTS161
  • NITRIC OXIDE SYNTHESIS IN PLANTS162
  • NITRIC OXIDE STORAGE, DELIVERY AND DETOXIFICATION IN PLANTS162
  • DNICS IN PLANTS163
  • PLANT IRON NUTRITION: AN OVERVIEW164
  • NITRIC OXIDE AND DNICS PARTICIPATION IN PLANT IRON METABOLISM165
  • PERSPECTIVES166
  • ACKNOWLEDGMENTS167
  • REFERENCES167
  • Part III: Nitrosospecies and S-nitrosothiols: Physico-chemical Properties and Biological Activity171
  • Chapter 9. Low-molecular-weight S-nitrosothiols173
  • SPECTROSCOPIC PROPERTIES175
  • SYNTHESIS AND DETECTION IN VITRO AND IN VIVO175
  • STABILITY OF GSNO IN VITRO179
  • STABILITY OF RSNO IN VIVO184
  • TRANSPORT OF LMW S-NITROSOTHIOLS186
  • BIOLOGICAL ACTIONS OF LMW NITROSOTHIOLS187
  • THERAPEUTIC USES OF LMW NITROSOTHIOLS191
  • REFERENCES193
  • Chapter 10. S-nitrosated proteins: formation, metabolism, and function201
  • INTRODUCTION201
  • BIOLOGICAL CHEMISTRY201
  • DETECTION205
  • PROTEOMICS207
  • FUNCTION OF S-NITROSOTHIOLS208
  • CONCLUSIONS211
  • ACKNOWLEDGMENTS212
  • REFERENCES212
  • Chapter 11. Chemical equilibria between S-nitrosothiols and dinitrosyl iron complexes with thiol-con223
  • INTRODUCTION223
  • THE REDOX REACTIONS OF COPPER224
  • DECOMPOSITION AND SYNTHESIS OF S-NITROSOTHIOLS BY IRON225
  • THE EXPERIMENTS WITH NEOCUPROINE SHOW THAT DECOMPOSITION AND SYNTHESIS OF RS-NO ARE CATALYZED BY COP226
  • THE MECHANISM OF CATALYTIC DECOMPOSITION OF RS-NO BY FERROUS IRON231
  • THE MECHANISM OF RS-NO SYNTHESIS CATALYZED BY IRON240
  • THE EQUILIBRIA BETWEEN THIOL-DNIC AND RS-NO245
  • NITROSOTHIOLS ARE NITRIC OXIDE DONORS THROUGH THEIR TRANSFORMATION INTO DNICS247
  • ACKNOWLEDGMENT250
  • REFERENCES251
  • Chapter 12. Cellular non-heme iron modulates apoptosis and caspase 3 activity253
  • INTRODUCTION253
  • SUMMARY OF OBSERVATIONS254
  • MECHANISTIC CONSIDERATIONS255
  • CONCLUSIONS262
  • REFERENCES263
  • Chapter 13. Nitrite and nitrosospecies in blood and tissue: approaching the gap between bench and be269
  • NITRIC OXIDE AND RED BLOOD CELLS270
  • RBC: A NOVEL SOURCE FOR NITRIC OXIDE271
  • NITRIC OXIDE AND PLASMA272
  • NITROSOSPECIES OTHER THAN RSNOS IN PLASMA273
  • NITRIC OXIDE SOLUTIONS273
  • NITRIC OXIDE CAN BE TRANSPORTED IN ITS FREE FORM ALONG THE VASCULAR TREE274
  • PLASMA RSNOS AS POTENTIAL DISEASE MARKERS274
  • ANALYSIS OF NITRIC OXIDE SPECIES: FINDING THE RIGHT APPROACH275
  • ANALYSIS OF NITRIC OXIDE SPECIES: FINDING THE RIGHT APPROACH275
  • PLASMA NITROSOSPECIES AND CARDIOVASCULAR DISEASE276
  • EFFECTS OF NITRIC OXIDE AND RSNOS ON LEFT VENTRICULAR FUNCTION277
  • PLASMA NITRITE AND ENOS-ACTIVITY277
  • ORIGIN OF PLASMA NITRITE280
  • NITRITE SIGNALING280
  • NITRITE AND DIAGNOSTICS281
  • TISSUE STORES OF NITRIC OXIDE281
  • SUMMARY282
  • REFERENCES282
  • Part IV: Nitrites and Nitrates as a NO Source in Cells and Tissues289
  • Chapter 14. Nitrite as endothelial NO donor under anoxia291
  • AQUEOUS REDUCTION PATHWAYS OF NITRITE294
  • IN VITRO EXPERIMENTS ON eNOS IN BUFFERED SOLUTION295
  • EXPERIMENTS ON ENDOTHELIAL CELL CULTURES298
  • MECHANISTIC HYPOTHESIS302
  • NITRIC OXIDE IS RELEASED FROM FULL-LENGTH eNOS BUT NOT FROM nNOS UNDER ANOXIA304
  • COMPARISON OF THE RATES OF NITRIC OXIDE GEMINATE RECOMBINATION TO THE HEME OF eNOS AND OF nNOS306
  • IMPLICATIONS FOR HUMAN PHYSIOLOGY308
  • REFERENCES309
  • Chapter 15. Nitrite as NO donor in cells and tissues313
  • INTRODUCTION313
  • XANTHINE OXIDASE-CATALYZED NITRITE REDUCTION314
  • EFFECT OF OXYGEN ON XO-MEDIATED NITRIC OXIDE GENERATION FROM NITRITE [2]319
  • MEASUREMENT OF NITRIC OXIDE FORMATION IN ISCHEMIC MYOCARDIUM [6,7,54]323
  • EVALUATION OF THE ROLE OF NITRITE-DERIVED NITRIC OXIDE IN POSTISCHEMIC INJURY326
  • NITROSYL-HEME FORMATION AND NITRIC OXIDE SIGNALING DURING BRIEF MYOCARDIAL ISCHEMIA327
  • CONCLUSION331
  • REFERENCES331
  • Chapter 16. The anti-microbial and cytotoxic actions of nitrite, and the use of DNIC as a marker for337
  • INTRODUCTION337
  • THE ANTI-MICROBIAL AND CYTOTOXIC ACTIVITIES OF NITRITE338
  • DNIC MAY BE USED AS A BIOMARKER FOR THE ANTI-MICROBIAL AND CYTOTOXIC ACTIONS OF NITRITE341
  • CONCLUDING REMARKS342
  • ACKNOWLEDGMENTS343
  • REFERENCES343
  • Chapter 17. Organic nitrates and nitrites as stores of NO bioactivity347
  • INTRODUCTION347
  • NITRATE THERAPEUTICS348
  • NITRITE THERAPEUTICS351
  • NITRATES AS NITRIC OXIDE MIMETICS351
  • ENDOGENOUS NITRATES AND NITRITES355
  • CHEMICAL REACTIVITY OF NITRATES356
  • CHEMICAL REACTIVITY OF NITRITES358
  • BIOLOGICAL REACTIVITY OF NITRATES AND BIOACTIVATION359
  • PATHWAYS FOR REDUCTION TO NITRIC OXIDE361
  • PROTEIN MEDIATORS OF BIOTRANSFORMATION364
  • NITRATE TOLERANCE368
  • SUMMARY369
  • REFERENCES369
  • Part V: Dithiocarbamate Iron Complexes: Implication for NO Studies381
  • Chapter 18. Mononitrosyl-iron complexes with dithiocarbamate ligands: physico-chemical properties383
  • INTRODUCTION383
  • LIGAND STRUCTURE OF IRON–DITHIOCARBAMATE COMPLEXES385
  • TRAPPING OF FREE NITRIC OXIDE BY IRON–DITHIOCARBAMATE COMPLEXES385
  • SPECTROSCOPIC PROPERTIES OF (NITROSYLATED) IRON–DITHIOCARBAMATE COMPLEXES389
  • ISOTOPIC SUBSTITUTIONS AFFECT THE EPR LINESHAPES OF THE MNIC ADDUCTS391
  • THE DETERMINANTS OF MNIC FORMATION IN TISSUES: REDOX STATE AND LIGANDS OF IRON392
  • REDUCTION WITH DITHIONITE ENHANCES MNIC YIELDS IN VIVO394
  • OTHER EFFECTS OF REDUCTION ON EPR SPECTRA396
  • PREVENTION OF REDUCTION OF ENDOGENOUS NITRITE BY BUFFERING397
  • DIFFERENT LIGANDS COMPETE WITH DETC FOR EXOGENOUS IRON IN TISSUES399
  • DIFFERENT LIGANDS COMPETE WITH DETC FOR EXOGENOUS IRON IN CULTURED ENDOTHELIAL CELLS399
  • LOOSELY BOUND IRON PARTICIPATES IN THE REDOX EQUILIBRIUM400
  • ENDOGENOUS COMPOUNDS AS IMPOSTORS FOR TRUE NITRIC OXIDE401
  • THE MEANING OF THE FERRIC HIGH-SPIN SIGNAL AT g = 4.3402
  • CONCLUDING REMARKS402
  • REFERENCES403
  • Chapter 19. Protection against allograft rejection by iron–dithiocarbamate complexes407
  • INTRODUCTION407
  • ROLE OF INOS IN CARDIAC REJECTION: EVIDENCE FROM PHARMACOLOGICAL APPROACHES407
  • ROLE OF INOS IN CARDIAC REJECTION: EVIDENCE FROM GENE DELETION STRATEGIES409
  • EFFECTS OF IRON–DITHIOCARBAMATES ON GRAFT SURVIVAL AND REJECTION409
  • EVIDENCE THAT IRON–DITHIOCARBAMATES ACT IN VIVO TO SCAVENGE NITRIC OXIDE410
  • IRON–DITHIOCARBAMATES FOR QUANTIFYING NITRIC OXIDE LEVELS414
  • EFFECT OF IRON–DITHIOCARBAMATES TO INHIBIT TARGETS OF NITRIC OXIDE414
  • ANTI-INFLAMMATORY ACTIONS OF DITHIOCARBAMATES417
  • EFFECTS ON LYMPHOCYTE ACTIVATION AND PROLIFERATION417
  • THE ROLE OF NITRIC OXIDE IN LYMPHOCYTE PROLIFERATION418
  • OTHER ACTIONS OF IRON–DITHIOCARBAMATES INVOLVING IMMUNOSUPPRESSION418
  • CONCLUSION419
  • ACKNOWLEDGMENTS419
  • REFERENCES419
  • INDEX423
Book details
  • Vendor Elsevier S & T
  • SKU 9780444522368
  • ISBN-13 9780080489599
  • Author van Faassen, Ernst; Vanin, Anatoly
  • Category Medical
  • Subject Pharmacology

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Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans.
Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers.
Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included.

* First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes
* Extensive bibliographic references, written by specialists of human physiology
* Providing high scientific quality with a focus on implications for human diseases