Elsevier S & T

Recent Advances in Nucleosides: Chemistry and Chemotherapy: Chemistry and Chemotherapy

Chu, C.K.

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Table of contents
  • Cover
  • Contentsv
  • Prefaceix
  • Chapter 1. Mission oriented research: An experience in Dr. Jack J. Fox's laboratory1
  • Chapter 2. Development of new radical reactions with a vinylsilyl group and their application to the21
  • Chapter 3. Synthesis of purine acyclonucleosides via ribofuranose-ring cleavage of purine nucleoside57
  • Chapter 4. The chemistry of nucleoside and dinucleotide inhibitors of nosine monophosphate dehydroge71
  • Chapter 5. Nucleoside and nucleotide prodrugs91
  • Chapter 6. Antiviral Isonucleosides: discovery, chemisry and chemical biology149
  • Chapter 7. Synthesis and biological activity of isopolar acyclic nucleotide analogs167
  • Chapter 8. Synthesis of pyranose nucleosides and related nucleosides with a six-membered carbohydrat239
  • Chapter 9. 5'-Norcarbanucleosides in L-like configurations291
  • Chapter 10. Tricyclic nucleosides revisited299
  • Chapter 11. Unusual analogues of nucleosides: chemistry and biological activity327
  • Chapter 12. Lithiation-based silylation and stannylation for nucleoside synthesis359
  • Chapter 13. Purine metabolism in parasites: potential targets for chemotherapy377
  • Chapter 14. Antiviral β-L-nucleosides specific for hepatits B virus infection417
  • Chapter 15. Antiviral activity of nucleoside analogues: the BVDU connection433
  • Chapter 16. The role of the cellular deoxynucleoside kinases in activation of nucleoside analogs use455
  • Chapter 17. Cellular transport of nucleotide analogs477
  • Chapter 18. 5-Aza-7-deazapurines: synthesis and properties of nucleosides and oligonucleotides505
Book details
  • Vendor Elsevier S & T
  • SKU 9780444509512
  • ISBN-13 9780080540368
  • Author Chu, C.K.
  • Category Medical
  • Subject Pharmacology

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The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs.