Selected Topics in the History of Biochemistry. Personal Recollections. VII: Personal Recollections. VII
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Table of contents
- Cover
- Copyright Pageiv
- CONTENTSxi
- Preface to Volume 42v
- Contributors to this Volumeix
- Chapter 1. Fifty Years in the World of Proteins1
- Origins1
- Cohn and Edsall6
- My First Project in Protein Science11
- The Invention of Polymer Science?12
- Macromolecules:Theoretical Research with J.G. Kirkwood14
- Antibodies19
- Genetic Basis forAntibody Diversity23
- Subunits and Allosterism24
- Micelles and Membranes28
- Membrane Proteins33
- Philip Handler and the Einstein Statue36
- Eastman Professor at Oxford39
- Popular Writing: Travel Books42
- Historical Perspective46
- References49
- Chapter 2. Proteins, Life and Evolution53
- Abstract53
- Introduction54
- CV of the Guide Through the Text55
- Early Days, Scientific Fathers56
- Cambridge, the Mecca at the Start57
- Development of Protein Sequence Analysis59
- SeparationTechniques and Continued Progress65
- Amino Acid Analysis, Complementary Approaches, and Further Development66
- Correlationwith 3-D Structures72
- Developments in Molecular Genetics76
- Molecular Evolution: Development from Early Diagonals,Ž over the Atlas Issues, to Bioinformatics79
- Mass Spectrometry85
- Present Situation, Including Comments on Karolinska, Nobel, and Funding89
- Summary of Revolutions93
- Perspectives94
- Acknowledgments97
- References97
- Chapter 3. Pehr Victor Edman:The Solitary Genius103
- Nature is the Guide105
- Science Takes Hold106
- Birth of an Idea109
- Idea Becomes True113
- Automation Must Come120
- End of Journey125
- Edman,The Person127
- Acknowledgments131
- References132
- Selected References from Pehr Edman’s Biography133
- Chapter 4. A Privileged Life137
- Introduction137
- Family Background138
- The Karolinska Institute140
- Establishing a Research Career152
- Permanent Position164
- The Royal Swedish Academy of Sciences192
- The Wenner–Gren Foundations209
- Concluding Thoughts214
- References217
- Chapter 5. RNA Enzymology and Beyond221
- Growing Up221
- Weizmann Institute of Science233
- St. Louis: Polynucleotide Phosphorylase236
- Isolation of High Molecular Weight Ribosomal RNA239
- The Single-Stranded Nature of rRNA240
- Early Studies on the Secondary Structure of RNA242
- tRNA Regulation245
- PNPase Research Applications253
- Differentiation of Artemia salina Cysts257
- Establishment of the Department of Neurobiology259
- Microtubule Proteins264
- Promoting International Links272
- References280
- Chapter 6. Some Selected Recollections from a Life with Biochemistry285
- Introduction285
- StudentYears at the University of Copenhagen286
- Experiments with Penicillin289
- Pupil of Herman Kalckar and Experiments with Xanthine Oxidase289
- Excursion to Two European Strongholds in Biochemistry292
- Ribose 1,5-Diphosphate293
- National Institutes of Health 1952–1953295
- Back in Copenhagen297
- Cancer Research299
- Experiments with 2′ -Deoxyadenosine300
- Experiments with 3′ -Deoxyadenosine303
- Back to the University of Copenhagen305
- Experiments with other Congeners of Adenosine306
- Experiments with DNA Polymerase from E. coli307
- Ribonucleotides Again312
- Regulation of Cellular Content of Nucleoside Triphosphates313
- Conclusion315
- References316
- Chapter 7. A Risky Job: In Search of Noncanonical Pathways319
- Introduction319
- In the Beginning319
- Challenge 1: Nonphosphorylating Respiration in Thermoregulation324
- Challenge 2: Initially any Respiration is Nonphosphorylating; Chemiosmosis337
- Challenge 4: Energy Coupling without H+: The Sodium World359
- Challenge 5: Respiration Which Kills Us364
- Challenge 6: Life without Science386
- Acknowledgments401
- References401
- Chapter 8. Fifty Years of Biochemistry as Enjoyed bya Medical Biochemist Motivated by an Interest in411
- Beginnings411
- Research420
- International Protein Phosphorylation Group432
- Other Activities at Bristol432
- Biochemistry Research at Oxford 1975–1993435
- Mechanisms Mediating the Role of the PDH Complex in Regulating Glucose Oxidation with Special Refere436
- Regulation of the Mitochondrial Branched Chain 2-Oxoacid Dehydrogenase Complex (BCDH Complex) by Rev438
- Other Contributions and Services441
- References442
- Chapter 9.My Happy Days with Lac Repressor-in a Dark World447
- Family and Childhood448
- Chemistry in Freiburg andMunich453
- With Howard Rickenberg in Bloomington, Indiana, 1963–1964458
- In the Watson-Gilbert Group 1965–1968461
- The First Ten Years in Cologne 1968–1977468
- The Next Ten Years in Cologne 1978–1987477
- The Last Ten Years Before my Retirement in Cologne 1988–1997483
- The First Four Years after my Retirement 1998–2001490
- Outlook492
- References494
- Chapter 10. A Dark Side of Science in Difficult Times501
- The Blood from Auschwitz and the Silence of the Scholars502
- Abstract502
- Von Verschuer, Excellent Scientist and Outspoken Anti-semite504
- Von Verschuer as a Practising Anti-Semite and Racist508
- Von Verschuer, Director, and Mengele, Former Post-doc, Now Guest and Collaborator, in the Berlin Kai510
- The Documents of the Auschwitz Research Project513
- Mengele in Auschwitz514
- Von Verschuer’s Research Activities in the Records of the Deutsche Forschungsgemeinschaft518
- Project I: Genetic Defects in Families and Twins519
- Project II: Genetic Differences among Jews, Gypsies and Others in Resistance to Infectious Diseases520
- 1945-1951: Von Verschuer has to Wait for a Professorship527
- Butenandt as Witness at the IG-Farben Trial in Nuremberg531
- Von Verschuer et al. Back to Normal Academic Life532
- The Silence of Von Verschuer and his Colleagues, Scientists and Historians535
- Other Examples of the General Disinterest in the Inglorious Past538
- Is there a Bottom Line?541
- References541
- Selective Perception: The Letters of Adolf Butenandt Nobel Prize Winner and President of The Max-Pla548
- Abstract548
- Introduction548
- Pre-History549
- Letters Exchanged between Butenandt and Von Verschuer from September 1944 to September 1945554
- Letters Exchanged between Butenandt and Hillmann: the Destruction of the Top Secret Papers557
- War Important Projects of Butenandt559
- Butenandt and National Socialism564
- Butenandt: Master of Selective Perception572
- Another View: Opportunisms and Power Hunger575
- Acknowledgments577
- References577
- The Fraud of Abderhalden’s Enzymes580
- Ute Delchmann and Benno Müller-Hill580
- Abderhalden’s Fraud581
- Why No One Stopped Him582
- Sinister Applications584
- Behind the Fraud586
- Can it Happen Again?588
- Acknowledgments589
- References589
- Chapter 11.The Sarcoplasmic Reticulum Ca2+ -ATPase and the Processes of Energy Transduction in Biolo591
- Introduction591
- Personal Memories593
- The Research Work616
- Science and Education636
- Science and Art638
- Final Statement640
- References640
- Name Index643
This book is the latest volume in a highly successful series within Comprehensive Biochemistry and provides a historical and autobiographical perspective of the development of the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. The book is essential reading for everybody, from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.