Elsevier S & T

Singlet Oxygen, UV-A and Ozone

Abelson, John N.; Simon, Melvin I.

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Table of contents

Table of Contentsv
Contributors to Volume 319xi
Prefacexvii
Volumes in Seriesxix
Section I: Singlet Oxygen1
A. Generation and Detection: Chemical Systems1
Chapter 1. Naphthalene Endoperoxides as Generators of Singlet Oxygen in Biological Media3
Chapter 2. Photosensitized Production of Singlet Oxygen20
Chapter 3. Singlet Oxygen from Irradiated Titanium Dioxide and Zinc Oxide29
Chapter 4. Time-Resolved Singlet Oxygen Detection37
Chapter 5.Measurement of Photogenerated Singlet Oxygen in Aqueous Media50
B. Generation and Detection: Biological Systems1
Chapter 6. Assay for Singlet-Oxygen Generation by Peroxidases Using 1270-nm Chemiluminescence59
Chapter 7. Formation of Electronically Excited States during the Oxidation of Arachidonic Acid by Pr67
Chapter 8. Singlet Oxygen Detection with Sterically Hindered Amine Derivatives in Plants under Light77
Chapter 9. Cholesterol as a Singlet Oxygen Detector in Biological Systems85
Chapter 10. Singlet Oxygen Scavenging in Phospholipid Membranes101
Chapter 11. Catalase Modification as a Marker for Singlet Oxygen110
C. Biological Effects: Role in Signaling1
Chapter 12. Nuclear Factor- kB Activation by Singlet Oxygen Produced during Photosensitization119
Chapter 13. Mitogen-Activated Protein Kinase Activation by Singlet Oxygen and Ultraviolet A130
D. Toxic Effects1
Chapter 14. Singlet Oxygen DNA Damage Products: Formation and Measurement143
Chapter 15. Ultraviolet A- and Singlet Oxygen-Induced Mutation Spectra153
Chapter 16. Damage to DNA by Long-Range Charge Transport165
Chapter 17. Cholesterol Photodynamic Oxidation by Ultraviolet Irradiation and Cholesterol Ozonizatio188
Chapter 18. Bactericidal and Virucidal Activities of Singlet Oxygen Generated by Thermolysis of Naph197
Chapter 19. Inactivation of Viruses in Human Plasma207
Chapter 20. 3-(4' -Methyl-1' -naphthyl)propionic Acid, 1' ,4' - Endoperoxide for Dioxygenation of Sq216
E. Protection: Singlet Oxygen Quenchers1
Chapter 21. Biological Singlet Oxygen Quenchers Assessed by Monomol Light Emission222
Chapter 22. Synthetic Singlet Oxygen Quenchers226
Section II: Ultraviolet A243
A. Dosimetry243
Chapter 23. Dosimetry of Ultraviolet A Radiation245
B. Biological Responses: Signaling243
Chapter 24. Radiation-Induced Signal Transduction255
Chapter 25. Signaling Pathways Leading to Nuclear Factor- kB Activation273
Chapter 26. Gene Regulation by Ultraviolet A Radiation and Singlet Oxygen280
Chapter 27. Role for Singlet Oxygen in Biological Effects of Ultraviolet A Radiation290
Chapter 28. Ultraviolet A-1 Irradiation as a Tool to Study the Pathogenesis of Atopic Dermatitis296
Chapter 29. Ultraviolet A Radiation-Induced Apoptosis302
Chapter 30. Singlet Oxygen-Triggered Immediate Preprogrammed Apoptosis309
Chapter 31. Determination of DNA Damage, Peroxide Generation, Mitochondrial Membrane Potential, and331
Chapter 32. Mechanism of Photodynamic Therapy-Induced Cell Death342
C. Biological Responses: Protocarcinogenesis, Photoaging, and Photoallergic Reactions243
Chapter 33. Photocarcinogenesis: UVA vs UVB359
Chapter 34. Photoaging-Associated Large-Scale Deletions of Mitochondrial DNA366
Chapter 35. Role of Activated Oxygen Species in Photodynamic Therapy376
Chapter 36. Gas Chromatography–Mass Spectrometry Analysis of DNA: Optimization of Protocols for Is401
D. Oxidative Damage Markers243
Chapter 37. Sequence Specificity of Ultraviolet A-Induced DNA Damage in the Presence of Photosensiti417
Chapter 38. Protein Oxidative Damage428
Chapter 39. DNA Damage Induced by Ultraviolet and Visible Light and Its Wavelength Dependence436
Chapter 40. Photoprotection of Skin against Ultraviolet A Damage445
E. Protection243
Chapter 41. Topically Applied Antioxidants in Skin Protection465
Chapter 42. Erythropoietic Protoporphyria: Treatment with Antioxidants and Potential Cure with Gene479
Chapter 43. Porphyrias: Photosensitivity and Phototherapy485
Chapter 44. Carotenoids in Human Skin: Noninvasive Measurement and Identification of Dermal Caroteno494
Section III: Ozone503
Chapter 45. Reactive Absorption of Ozone: An Assay for Reaction Rates of Ozone with Sulfhydryl Compo505
Chapter 46. Assay for Singlet Oxygen Generation by Plant Leaves Exposed to Ozone512
Chapter 47. Ozone Effects on Plant Defense520
Chapter 48. High-Pressure Liquid Chromatography Analysis of Ozone-Induced Depletion of Hydrophilic a536
Chapter 49. Reactions of Vitamin E with Ozone546
Chapter 50. Induction of Nuclear Factor-kB by Exposure to Ozone and Inhibition by Glucocorticoids551
Chapter 51. Detection of 4-Hydroxy-2-nonenol Adducts Following Lipid Peroxidation from Ozone Exposur562
Chapter 52. Synthesis of Inflammatory Signal Transduction Species Formed during Ozonation and/or Per570
Section IV: General Methods583
Chapter 53. Assay for Redox-Sensitive Transcription Factor585
Chapter 54. Fluorescent Fatty Acid to Monitor Reactive Oxygen in Single Cells603
Chapter 55. Noninvasive Techniques for Measuring Oxidation Products on the Surface of Human Skin612
Author Index623
Subject Index661

Book details

Vendor Elsevier S & T
SKU 9780121822200
ISBN-13 9780080496764
Author Abelson, John N.; Simon, Melvin I.
Category Medical
Subject Pharmacology

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Recent advances in understanding the biological role of singlet oxygen in the pathways of cellular responses to ultraviolet-A radiation: its key position in photodynamical effects, and its generation by photochemical (dark) reactions, e.g. by cells of the immune system such as eosinophils and macrophages, are the focus of this volume. The new methods and techniques responsible for the rapid progress in this area are presented.

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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