Elsevier S & T

Somitogenesis, Part 2

Pedersen, Roger A.

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Table of contents
  • Contentsv
  • Contributorsix
  • Prefacexi
  • Chapter 1. Evolution and Development of Distinct Cell Lineages Derived from Somites1
  • I. Introduction2
  • II. Metamerism2
  • III. Somite Research Past and Present6
  • IV. Resegmentation14
  • V. The Muscle Lineage26
  • VI. Further Somitic Derivatives: Dermis, Smooth Muscle, and Angioblasts32
  • VII. Evolution of Metamerism in Vertebrates34
  • References40
  • Chapter 2. Duality of Molecular Signaling Involved in Vertebral Chondrogenesis43
  • I. Origin of the Vertebrae and Intervertebral Disks43
  • II. Gene Expression in the Developing Somitic Cells44
  • III. The Dorsal Neural Tube Grafted Ectopically Promotes Dorsal Cartilage Formation in a Subectoderm51
  • IV. Ventral Axial Structures Prevent Subectodermal Cartilage Formation54
  • V. Molecular Pathways Leading to Chondrogenesis in the Vertebra57
  • VI. Conclusions: A Novel Model for Vertebra Development65
  • References
  • Chapter 3. Sclerotome Induction and Differentiation77
  • I. Introduction77
  • II. Induction: Definitions78
  • III. Anatomical and Morphological Description of Sclerotome Development79
  • IV. Genetics83
  • V. Nonmolecular Approaches85
  • VI. The Molecular Approach98
  • VII. Shh, cAMP, and Sclerotome106
  • VIII. Issues Concerning Shh as the Sclerotome Inducer106
  • IX. Initiation of the Sclerotome108
  • X. Shh, Noggin, and Somite Chondrogenesis109
  • XI. Bone Morphogenetic Proteins and Sclerotome Development110
  • XII. Determination of the Sclerotome110
  • XIII. Epithelial–Mesenchymal Transitions and Sclerotome Formation113
  • XIV. Dorsal–Ventral Patterning of the Somite113
  • XV. Interactions between the Somitic Components114
  • XVI. Discussion115
  • XVII. Summary117
  • References118
  • Chapter 4. Genetics of Muscle Determination and Development129
  • I. Introduction129
  • II. The Origin of Skeletal Muscles in Vertebrate Organisms130
  • III. The MyoD Family of Muscle-Specific Transcription Factors131
  • IV. Development of the Limb Musculature151
  • V. Structures Surrounding the Somites and Signals Emanating from Them Affect Myogenesis153
  • VI. The Myogenic Potential of Mesoderm: Induction or Derepression?155
  • References157
  • Chapter 5. Multiple Tissue Interactions and Signal Transduction Pathways Control Somite Myogenesis165
  • I. Introduction166
  • II. Mesodermal Origins of Skeletal Muscle in Vertebrate Embryos167
  • III. Regulatory Genes That Control Somite Myogenesis170
  • IV. Tissue Interactions That Control Somite Myogenesis174
  • V. Signaling Molecules and Transduction Pathways Controlling Myogenesis in Somites185
  • VI. Overview and Future Perspectives207
  • References212
  • Chapter 6. The Birth of Muscle Progenitor Cells in the Mouse: Spatiotemporal Considerations225
  • I. Introduction225
  • II. Origins of Skeletal Muscle in Vertebrates226
  • III. Domains of the Dermomyotome227
  • IV. Differences between Somites at Different Axial Levels235
  • V. Myogenic Regulatory Factor Expression Patterns in the Somite and Myotome Heterogeneity237
  • VI. Extrinsic Factors Govern Somite Differentiation and the Activation of Myf5 and MyoD242
  • VII. Do Myf5 and MyoD Define Different Subpopulations of Muscle Cells?246
  • VIII. The Roles of Myf5 and MyoD in Muscle Progenitor Cell Determination250
  • IX. Conclusions260
  • References261
  • Chapter 7. Mouse–Chick Chimera: An Experimental System for Study of Somite Development269
  • I. Introduction269
  • II. Technical Aspects271
  • III. Somitic Lineage into Somite Chimera274
  • IV. Epaxial Myogenic Lineage into Neural Tube Chimera289
  • V. What Is the Benefit of the Somite–Neural Tube Chimera?292
  • VI. Concluding Remarks294
  • References296
  • Chapter 8. Transcriptional Regulation during Somitogenesis301
  • I. Introduction301
  • I. Regulation of Hox Gene Expression302
  • III. Control of Myogenic Regulatory Factor Gene Expression306
  • IV. Roles of Non-MRF Transcription Factors in Muscle Development311
  • V. The Identification of Novel Somite-Specific Transcripts312
  • References315
  • Chapter 9. Determination and Morphogenesis in Myogenic Progenitor Cells: An Experimental Embryologic319
  • I. Introduction320
  • II. The Diversity and Location of Muscle Precursor Cells in the Vertebrate Embryo325
  • III. When Do Myotome Precursor Cells Become Determined?344
  • IV. Gene Expression and Determination in Migratory Limb Muscle Precursor Cells350
  • V. A Cellular and Molecular Framework for Understanding Myogenic Tissue Development353
  • VI. Appendix: Key Word Guide360
  • References361
  • Index369
  • Contents of Previous Volumes389
Book details
  • Vendor Elsevier S & T
  • SKU 9780121531485
  • ISBN-13 9780080494388
  • Author Pedersen, Roger A.
  • Category Science
  • Subject Developmental Biology

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Description eBook delivery & access Reviews
The chapters contained in this two-volume set provide a broad perspective on the novel strategies and conceptual paradigms that drive the current resurgence of interest in somitogenesis - the process by which somites form and elaborate differentiated tissues and structures. Because somites are a ubiquitous feature of vertebrate embryos, they can be studied in a variety of experimental animal models including those amenable to genetic (zebrafish, mammalian), molecular/genetic (mammalian, avian) as well as those already well established for classical experimental embryological and cell biological studies (amphibians, avian). The wide variety of experimental approaches to somitogenesis that are presented in these volumes will leave the reader with a broad perspective on how current research in somitogenesis is helping to solve fundamental questions in vertebrate development and morphogenesis.

Key Features
* Novel transcriptional mechanisms that control repetitive pattern formation
* Wide-scale genetic screens for mutations affecting somitogenesis
* Molecular/genetic control of pattern and tissue formation during somitogenesis
* Transplantation of mouse embryo somites
* Classical embryological approaches and concepts
* Evolutionary perspectives on somitogenesis