Elsevier S & T

Stories of Success: Personal Recollections. X

Semenza, Giorgio

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Table of contents
  • Cover
  • Contentsxi
  • Preface to Volume 45v
  • Contributors to this volumeix
  • Chapter 1. Odyssey of a Biochemist1
  • Abstract1
  • Growing Up in Three Different Countries2
  • Diamonds in the Desert5
  • Back to U.S.A.13
  • Discovery of Oxygenases18
  • Kyoto University, My Second Alma Mater22
  • The Mystery of Sleep24
  • Osaka Bioscience Institute31
  • Nature is the Guide34
  • Acknowledgments34
  • References35
  • Chapter 2. A Voyage to the Inner Space of Cells37
  • Abstract38
  • Introduction38
  • Apprenticeship with Great Freedom38
  • Heading into New Directions40
  • The First Decade in Martinsried: Studying Protein Architecture on Prokaryotic Cell Surfaces43
  • The Next Decade: Proteasomes, Thermosomes and Other Elements of Intracellular Protein Quality Contro45
  • The Latest Frontier: Charting Molecular Landscapes Inside Cells by Cryoelectron Tomography52
  • References61
  • Chapter 3. Fixed to Translation: A Recollection69
  • Abstract70
  • Early Years70
  • From Aminoacyl-tRNA Synthetases to Ribosomes73
  • An Excursion to Archaea77
  • Regulation of Fermentation81
  • The Biosynthesis and Insertion of the Metal Centre of [NiFe]– Hydrogenases87
  • Selenium Biochemistry96
  • Relations to Industry117
  • Resume and Outlook120
  • Remarks121
  • References121
  • Chapter 4. Dennis Chapman: Oiling the Path to Biomembrane Structure127
  • Abstract128
  • Dennis Chapman: The Scientist128
  • Gonville and Caius, Cambridge134
  • The Frythe Laboratories, Welwyn135
  • Reckitt & Coleman, Sheffield University139
  • London University, Chelsea College142
  • London University, Royal Free Hospital Medical School147
  • London University, Interdisciplinary Research Centre151
  • Dennis Chapman, The Man151
  • Acknowledgements154
  • References154
  • Chapter 5. Embden–Meyerhof–Parnas, the First Metabolic Pathway: The Fate of Prominent Polish Bio157
  • Abstract157
  • Introduction158
  • Biography: Life, Work and Tragic Fate of Jakub Karol Parnas161
  • Parnas’ and Collaborators’ Contribution to Discovery of Glycolysis183
  • The Parnas’ School of Biochemistry189
  • The Polish Biochemical Society and Its Activities Undertaken to Honor Jakub Karol Parnas198
  • Acknowledgments199
  • References199
  • Biographic Data206
  • Chapter 6. A Journey with Bleeding Time Factor209
  • Abstract209
  • And Then There Was a New Disease210
  • Bleeding Time Factor – Really?213
  • Factor Aims at Platelets222
  • Factor Dimmed and Brought to Light223
  • Factor, A Series of Huge Polymers225
  • Factor, Polymers of a Single-Chain Protein226
  • Factor, We See You!231
  • Factor Loves Factor VIII233
  • Factor in Dialogue with Platelets and Vessel Wall235
  • Factor Missing or Malformed238
  • Factor Checked by Guardian240
  • Has Factor Other Guardians?244
  • Acknowledgment245
  • References246
  • Chapter 7. A Neuropathologist’s Diary257
  • Abstract258
  • Zurich, Part I: Brains of Humans and Mice260
  • The Vienna Experience261
  • Zurich, Part II: Tracking Prions262
  • A Function for the Prion Protein268
  • The Future of Prion Therapeutics269
  • Immunotherapy against Prions?270
  • Soluble Prion Antagonists271
  • Inflammation: A License to Replicate?272
  • Homework for the Next Few Years274
  • Life Science and Animal Experiments275
  • Acknowledgments277
  • References277
  • Chapter 8. An Autobiographical Sketch: 50 Years in Cancer Immunochemistry283
  • Abstract283
  • University285
  • In the Laboratory: Searches and Findings293
  • Resonance and Subsequent Studies316
  • Concluding Remarks322
  • Acknowledgments333
  • References333
  • Index335
  • Colour Plate SectionColour Pla
Book details
  • Vendor Elsevier S & T
  • SKU 9780444522467
  • ISBN-13 9780080553573
  • Author Semenza, Giorgio
  • Category Science
  • Subject Genetics & Genomics

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This book is the latest volume in the highly successful series Comprehensive Biochemistry. It provides a historical and autobiographical perspective of the developments in the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. Volume 45 is essential reading for everyone from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.

* Contributors are distinguished scientists in the field
* Unique series of personal recollections
* Presents scientific research in a historical perspective