T Cell Subsets: Cellular Selection, Commitment and Identity
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Table of contents
- Advances in Immunology: T Cell Subsets: Cellular Selection, Commitment and Identityiii
- Copyright Pageiv
- Contentsv
- Contributorsix
- Introductionxi
- Chapter 1. Lineage Commitment and Developmental Plasticity in Early Lymphoid Progenitor Subsets1
- I. Introduction1
- II. Hematopoietic Stem Cells: Clonogenic Precursors of the Hematolymphoid System2
- III. Cell Fate Determination: How do HSCs Commit to Each of the Hematolymphoid Lineages?3
- IV. Overview of T and B Lymphoid Differentiation6
- V. Defining the Earliest Stage in Lymphoid Commitment: Isolation of Common Lymphoid Progenitors (CLP7
- VI. Is the CLP Stage Necessary for Adult Lymphoid Differentiation?13
- VII. Common Myeloid Progenitors as the Counterpart of CLPs17
- VIII. Lineage Priming by Promiscuous Gene Expression in Multipotent Stem and Progenitor Cells18
- IX. Lymphoid and Myeloid Promiscuity Demonstrated by Single-Cell Analyses19
- X. Fate Choices Made by Combinations of Instructive Signals at Lineage Promiscuous Stages22
- XI. Lineage Plasticity in Lymphoid Progenitors: Fate Choices are Reversible28
- XII. Comparison of Gene Expression Profiles among Early Hematopoietic Stem and Progenitor Cells32
- XIII. Early Lymphoid Progenitors can Differentiate into Antigen-presenting Dendritic Cells33
- XIV. Fetal Hematopoietic Progenitors are Not Fully Committed to the Lymphoid and Myeloid Fates35
- XV. Lymphoid- and Myeloid-restricted Progenitors in Human Bone Marrow38
- XVI. Clinical Relevance39
- XVII. Conclusion39
- References40
- Chapter 2. The CD4/CD8 Lineage Choice: New Insights into Epigenetic Regulation during T Cell Develop55
- I. Introduction55
- II. Role of Coreceptors in T Cell Development56
- III. Regulation of CD4 Gene Expression59
- IV. Regulation of CD8 Gene Expression77
- V. Conclusion86
- References86
- Chapter 3. CD4/CD8 Coreceptors in Thymocyte Development, Selection, and Lineage Commitment: Analysis91
- I. Introduction91
- II. Early Thymocyte Development91
- III. CD4 and CD8 Coreceptor Molecules on DP Thymocytes95
- IV. Selection and Commitment: Classical Models99
- V. Kinetic Signaling as an Alternative to Classical Models of Lineage Commitment110
- VI. Conclusions121
- References121
- Chapter 4. Development and Function of T Helper 1 Cells133
- I. Introduction133
- II. Factors Inducing the Development of Th1 Cells And Their Production of IFN-γ135
- III. Role of Th1 Signaling Components in In Vivo Immune Responses144
- IV. Transcriptional Regulation for Th1 Cells Producing IFN-γ146
- V. New Cytokines: What is Their Role in Th1 Cell Responses?149
- VI. Inherited Disorders of IL-12 and IFN-γ-mediated Immunity: Clinical Outcomes of Defects in Th1 D151
- References153
- Chapter 5. Th2 Cells: Orchestrating Barrier Immunity163
- I. Introduction: History and Definitions163
- II. Activation of IL-4 Expression in Naive CD4 T Cells164
- III. Stabilization of IL-4 Expression in T Cells167
- IV. Phenotype and Genotype Analysis of Th2 Cells170
- V. Mutations Impacting IL-4 Expression in T Cells171
- VI. Expression of IL-4 in Non-Th2 Cells171
- VII. Where Does Type 2 Immunity Operate?177
- VIII. Concluding Remarks179
- References180
- Chapter 6. Generation, Maintenance, and Function of Memory T Cells191
- I. Introduction191
- II. What Is a Memory Cell?192
- III. Where Do Memory CD8+ T Cells Come From?198
- IV. How Are Memory Cells Maintained?212
- V. Conclusions220
- References221
- Chapter 7. CD8+ Effector Cells233
- I. Effector Cells Defined233
- II. Secretion as the Mechanism of Effector Function235
- III. Cytotoxicity In Vivo236
- IV. Cytotoxicity In Vitro238
- V. Perforin-dependent Granule Exocytosis Pathway238
- VI. FasL/Fas Death Pathway242
- VII. Cytokine Secretory Effector Cells243
- VIII. CD8+ T Cell Differentiation245
- IX. Conclusions249
- References250
- Chapter 8. An Integrated Model of Immunoregulation Mediated by Regulatory T Cell Subsets253
- I. Introduction and Objectives253
- II. Historical Considerations: Clonal Selection Theory, Immunoregulation, and Regulatory T Cell Subs254
- III. The T Cell Subsets which Mediate Suppression of the Immune Response261
- IV. An Integrated Model of Immunoregulation by NKT, CD4+CD25+, and Qa-1 Restricted CD8+ T Cell Subse277
- References281
- Index289
- Contents of Recent Volumes301
- Color Plate SectionColor Plate-1
This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity.
T Cell Subsets is a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers
T Cell Subsets is a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers