Elsevier S & T

The Alkaloids: Chemistry and Biology

Cordell, Geoffrey A.

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Table of contents
  • Cover
  • Title Pageiii
  • Copyright Pageiv
  • Contentsv
  • Contributorsvii
  • Prefaceix
  • Chapter 1. Clinical Studies of Camptothecin and Derivatives1
  • I. Introduction1
  • II. Mechanisms of Action3
  • III. Mutagenicity and Resistance Mechanisms7
  • IV. Irinotecan9
  • V. Topotecan19
  • VI. Considerations of Route of Administration27
  • VII. Investigational Derivatives29
  • VIII. Conclusions33
  • References.35
  • Chapter 2. Tremorgenic and Nontremorgenic 2,3-Fused Indole Diterpenoids51
  • I. Introduction51
  • II. Isolation53
  • III. Synthesis125
  • IV. Biosynthesis144
  • V. Structure and Tremorgenicity155
  • References158
  • Chapter 3. The Daphniphyllum Alkaloids165
  • I. Introduction165
  • II. Structures of Representative Alkaloids170
  • III. Biosynthesis and Biogenesis184
  • IV. Synthesis193
  • V. Conclusions202
  • References203
  • Chapter 4. The Manzamine Alkaloids207
  • I. Introduction207
  • II. Isolation and Structure Elucidation from Marine Sponges214
  • III. Biogenesis and Biosynthesis223
  • IV. Synthesis264
  • V. Pharmacology270
  • VI. Conclusions277
  • References278
  • Chapter 5. Sesquiterpene Pyridine Alkaloids287
  • I. Introduction287
  • II. Evoninate Sesquiterpene Pyridine Alkaloids and Derivatives289
  • III. Wilfordate Sesquiterpene Pyridine Alkaloids and Derivatives307
  • IV. Edulinate Sesquiterpene Pyridine Alkaloids315
  • V. Cassinate Sesquiterpene Pyridine Alkaloids317
  • VI. Lower Molecular Weight Sesquiterpene Pyridine Alkaloids.317
  • VII. Non-Celastraceous Sesquiterpene Pyridine Alkaloids318
  • VIII. Biosynthesis and Biogenesis322
  • IX. Biological Activity330
  • X. Taxonomic Considerations334
  • XI. Synthesis334
  • References339
  • Chapter 6. Chemical and Biological Aspects of Melanin345
  • I. Introduction345
  • II. Biogenesis of Melanin347
  • III. Natural Melanins354
  • IV. Investigations of Melanins by Physical Methods373
  • V. Synthetic Melanins376
  • VI. Physicochemical Properties and Biological Functions of Melanins379
  • References384
  • Index393
Book details
  • Vendor Elsevier S & T
  • SKU 9780124695603
  • ISBN-13 9780080521497
  • Author Cordell, Geoffrey A.
  • Category Science
  • Subject Organic

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Description eBook delivery & access Reviews
This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than forty years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective.

Comprehensive dynamic reviews written by the leading authors in the respective fields.

Broader coverage than before on the biological aspects.