Elsevier S & T

The Alkaloids: Chemistry and Biology

Cordell, Geoffrey A.

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Table of contents
  • Contentsv
  • Contributorsvii
  • Prefaceix
  • Chapter 1. Molecular Modes of Action of Cytotoxic Alkaloids: From DNA Intercalation, Spindle Poisoni1
  • I. Introduction1
  • II. Molecular Targets of Secondary Metabolites2
  • III. Cytotoxicity of Alkaloids5
  • IV. Molecular Modes of Action of Cytotoxic Alkaloids8
  • V. Conclusions37
  • Acknowledgments38
  • References38
  • Chapter 2. Calystegines49
  • I. Introduction50
  • II. Structures and Chemical Properties50
  • III. Isolation and Analysis of Calystegines56
  • IV. Occurrence of Calystegines in the Plant Kingdom61
  • V. Biosynthesis71
  • VI. Chemical Synthesis82
  • VII. Biochemical Activities84
  • VIII. Activity of Calystegines in Plants92
  • References94
  • Chapter 3. Recent Studies on the Synthesis of Strychnine103
  • I. Introduction104
  • II. An Overview of the Earlier Syntheses of Strychnine (1954–1999)106
  • III. Recent Syntheses of Strychnine (2000–2006)118
  • IV. Concluding Remarks130
  • Acknowledgments133
  • References134
  • Chapter 4. Alkyl, Aryl, Alkylarylquinoline, and Related Alkaloids139
  • I. Introduction139
  • II. Biosynthesis and Biogenesis140
  • III. Biological Activity185
  • IV. Alkyl, Aryl, Alkylarylquinoline, and Related Alkaloids: Their Distribution and Systematic Signif197
  • V. Summary and Conclusions205
  • References206
  • Cumulative Index of Titles215
  • Subject Index223
Book details
  • Vendor Elsevier S & T
  • SKU 9780123739117
  • ISBN-13 9780080555768
  • Author Cordell, Geoffrey A.
  • Category Science
  • Subject Organic

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Description eBook delivery & access Reviews
This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

* Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective
* Comprehensive dynamic reviews written by the leading authors in their respective fields
* Broader coverage than before on the biological aspects