Elsevier S & T

The Centrosome in Cell Replication and Early Development

Palazzo, Robert E.

In stock

No reviews

83.250 KD inc. VAT

License

perpetual

Table of contents

Contentsvii
Contributorsxv
Prefacexix
Chapter 1. The Centrosome and Parthenogenesis1
I. Introduction1
II. Toward a Functional Description of the Centrosome2
III. The Centrosome Organelle versus Self-Assembled Centers12
IV. Centrosome Reproduction and the Parthenogenetic Activity of the Centrosome13
V. Conclusion18
References19
Chapter 2. y-Tubulin27
I. Centrosomes and Microtubule Nucleation27
II. y-Tubulin and the Tubulin Superfamily of Proteins30
III. Distribution of y-Tubulin in Cells33
IV. Studies of y-Tubulin Function39
V. y-Tubulin and Microtubule Assembly: Current Knowledge and Unanswered Questions45
VI. Concluding Remarks49
References49
Chapter 3. y-Tubulin Complexes and Their Role in Microtubule Nucleation55
I. Introduction55
II. Biochemical and Structural Studies of y TuRC and y TuSC57
III. Evidence That y TuRC Is the Major Microtubule Nucleator at the Centrosome64
IV. The Mechanism of Microtubule Nucleation65
V. Concluding Remarks69
References70
Chapter 4. y-Tubulin of Budding Yeast75
I. Introduction75
II. Tubulins of Yeast80
III. Interactions between Tubulins88
IV. The g -Tubulin Complex in Yeast91
V. Future Directions95
References97
Chapter 5. The Spindle Pole Body of Saccharomyces cerevisiae: Architecture and Assembly of the Core105
I. Introduction105
II. SPB Duplication and Assembly of the Mitotic Spindle106
III. Structure of the SPB107
IV. SPB Core Components109
V. Assembly of the Core SPB Components122
VI. Transcriptional Regulation of Core SPB Components123
VII. Homologs of Spindle Pole Components in Other Organisms124
VIII. Future Directions125
References128
Chapter 6. The Microtubule Organizing Centers of Schizosaccharomyces pombe133
I. Introduction133
II. Cytoplasmic Microtubule Organizing Centers136
III. The Spindle Pole Body138
IV. Molecular Characterization of SPB Components149
V. Perspectives153
References154
Chapter 7. Comparative Structural, Molecular, and Functional Aspects of the Dictyostelium discoideum161
I. Introduction161
II. Comparative Morphology of the Dictyostelium Centrosome163
III. Comparative Analysis of Dictyostelium Centrosome Duplication167
IV. Comparative Molecular Biology of the Dictyostelium Centrosome171
V. Conclusions179
References179
Chapter 8. Are There Nucleic Acids in the Centrosome?187
I. Introduction187
II. Do Centrioles or Centrosomes Contain DNA?188
III. Do Centrosomes Contain RNA?197
IV. Conclusions201
References202
Chapter 9. Basal Bodies and Centrioles: Their Function and Structure207
I. Introduction to Centrioles and Basal Bodies207
II. The Structure of Centrioles and Basal Bodies212
III. The Function of Basal Bodies and Centrioles as Revealed by Mutational Analysis221
IV. Basal Body/Centriole Replication226
References228
Chapter 10. Centriole Duplication and Maturation in Animal Cells235
I. Overview235
II. Centriole Lineage Patterns236
III. Structural Features of Centriole Maturation and Duplication236
IV. Centriolar Duplication, Maturation, and the Cell Cycle239
V. Centriolar Maturation and Centriolar Function242
VI. Ciliogenesis and Cell Cycle244
VII. Future Developments and Directions245
References245
Chapter 11. Centrosome Replication in Somatic Cells: The Significance of the G1 Phase251
I. Introduction251
II. The Cell Cycle in Somatic Mammalian Cells251
III. Electron Microscopic Descriptions of Centrosome Doubling, and the Cellular Events of Centrosome252
IV. Spindle Pole Body Doubling in Yeast Cells255
V. Events in G1 That Trigger Centrosome Replication in Somatic Mammalian Cells260
VI. Summary263
References264
Chapter 12. The Coordination of Centrosome Reproduction with Nuclear Events during the Cell Cycle267
I. Introduction267
II. The Events of Centrosome Reproduction269
III. Controls for Centrosome Reproduction271
IV. Coordination of Centrosome Reproduction with Nuclear Events in the Cell Cycle276
References286
Chapter 13. Regulating Centrosomes by Protein Phosphorylation291
I. Introduction291
II. Protein Phosphorylation: A Major Theme in Cell Cycle Control292
III. Centrosome and Spindle Pole Body Dynamics through the Cell Cycle294
IV. In Control of Centrosome Duplication295
V. Regulating Microtubule Nucleation298
VI. Establishing a Bipolar Mitotic Spindle300
VII. Creating the Zygotic Centrosome305
VIII. Loss of Phosphorylation Control: Cancer Implications306
IX. Perspectives: Into the Next Millennium308
References309
Chapter 14. The Role of the Centrosome in the Development of Malignant Tumors313
I. Introduction313
II. Centrosome Defects and Abnormal Mitoses in Cancer316
III. Amplified Centrosomes and Aneuploidy317
IV. Excess Pericentriolar Material Is Associated with High Frequency of Abnormal Mitoses319
V. Centrosome-Associated Kinases and Cancer320
VI. Tumor Suppressor Proteins and the Centrosome321
VII. Maintenance of Cell and Tissue Polarity Minimizes Tumor Aggression in Model Systems324
VIII. Conclusions325
References326
Chapter 15. The Centrosome-Associated Aurora/Ipl-like Kinase Family331
I. Introduction331
II. The Aurora and Ipl-like Family: Structure, Regulation and Substrates333
III. Summary339
References340
Chapter 16. Centrosome Reduction during Mammalian Spermiogenesis343
I. Introduction343
II. Overview of Mammalian Spermiogenesis345
III. Stages of Centrosome Reduction during Spermiogenesis347
IV. Conclusions357
References357
Chapter 17. The Centrosome of the Early C. elegans Embryo: Inheritance, Assembly, Replication, and D365
I. Why C. elegans?365
II. Origin and Replication of the Zygotic Centrosomes367
III. The Central Role of the Centrosome–Pronucleus Complex in Specifying AP Polarity374
IV. Nuclear Positioning378
V. Concluding Remarks380
References381
Chapter 18. The Centrosome in Drosophila Oocyte Development385
I. Introduction385
II. The Germarium: Centrosomes Are Anchored to Achieve Polarized Cell Divisions387
III. The Oocyte MTOC391
IV. Meiosis396
V. Summary400
References402
Chapter 19. The Centrosome in Early Drosophila Embryogenesis409
I. Introduction410
II. Ultrastructure412
III. Composition415
IV. Duplication and Separation421
V. Fertilization and the First Mitotic Division427
VI. Precortical Divisions430
VII. Cortical Divisions432
References440
Chapter 20. Centrosome Maturation449
I. Introduction449
II. Centrosome Maturation451
III. Centrosome Structure and Microtubule Nucleation Potential453
IV. The Role of the Centriole457
V. The Procentrosome458
VI. Paternal versus Maternal Centrosomes460
VII. Summary462
References463
Index471
Contents of Previous Volumes485

Book details

Vendor Elsevier S & T
SKU 9780121531492
ISBN-13 9780080488622
Author Palazzo, Robert E.
Category Science
Subject Cell Biology

Do you have questions about this book?

Ask an expert!

Centrosomes play an integral role in the growth of cells and the ultimate development of many animals, and sometimes plants. In addition to the normal growth of cells, centrosomes can also play a key role in the spread of cancer and are of increased interest to both the genetics and oncology communities. Volume 49 of Current Topics in Developmental Biology will present all known research surrounding the centrosome, across a variety of systems, will be well referenced, and speculate where the research is headed.

Key Features
* Discusses centrosomes and cancer, centrosomes and early development, and molecular biology of the centrosome
* Heavily illustrated, with many color figures
* Chapters written by international leaders in the field

Instant delivery by email
Your access email arrives within minutes of checkout, with a sign-in link for each book — no shipping, no waiting.

Read on any device
Books open in VitalSource Bookshelf on your phone, tablet, or computer, online or offline. Your library is always available at aafaq.vitalsource.com — just log in with the email you used at checkout.

Lost the email?
Resend it to yourself in seconds from My eBook orders, or email cs@aafaqeducation.com and we'll help.