Elsevier S & T

The Combinatorial Index

Bunin, Barry A.

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Table of contents
  • Contentsv
  • Forewordxv
  • Acknowledgmentsxvii
  • Chapter 1. Introduction1
  • Chapter 2. Background5
  • Chapter 3. Linkers for Solid-Phase Synthesis9
  • 3.1 Resin Derivatization11
  • 3.2 Linkers for Carboxylic Acids15
  • 3.3 Linkers for Amides37
  • 3.4 Linkers for Alcohols and Amines52
  • 3.5 Linkers for Hydrocarbons and Other Functional Groups65
  • Chapter 4. Combinatorial Solid-Phase Synthesis77
  • 4.1 Condensations to Prepare Amides, Esters, Ureas, Imines, and Phosphorus Compounds77
  • 4.2 Carbon-Carbon Bond Formation on Solid Support90
  • 4.3 Mitsunobu Reactions on Solid Support106
  • 4.4 Substitution and Addition Reactions on Solid Support112
  • 4.5 Oxidations on Solid Support130
  • 4.6 Reductions on Solid Support133
  • 4.7 Preparation of Heterocyclic Compounds143
  • Chapter 5. Analytical Methods for Solid-Phase Synthesis213
  • 5.1 Colormetric Assays on Solid Support214
  • 5.2 Identification of Compounds Released from Resin219
  • 5.3 NMR Techniques for Solid-Phase Synthesis220
  • 5.4 IR Techniques for Solid-Phase Synthesis228
  • 5.5 Mass Spectrometry Techniques for Solid-Phase Synthesis233
  • 5.6 Other Analytical Methods for Combinatorial Synthesis235
  • Chapter 6. Preparation of Solution Libraries and Combined Approaches at the Solution/Solid-Phase Int237
  • 6.1 Solution Libraries240
  • 6.2 Resin Capture259
  • 6.3 Support-Bound Reagents262
  • Appendix 1. Summary of Functional Group Transformations for Combinatorial Solid-Phase Synthesis281
  • Appendix 2. Classification of Heterocyclization Reactions295
  • Appendix 3. Unnatural Biopolymers303
  • Appendix 4. Oligosaccharides305
  • Appendix 5. List of Abbreviations307
  • Author Index309
  • Subject Index319
Book details
  • Vendor Elsevier S & T
  • SKU 9780121413408
  • ISBN-13 9780080542409
  • Author Bunin, Barry A.
  • Category Medical
  • Subject Pharmacology

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Description eBook delivery & access Reviews
With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity.

Key Features
* Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods
* Serves as a laboratory manual for bench chemists
* Includes a chapter on linkers to assist in choice of linking strategy
* Discusses strengths and limitations of the various methods
* Contains a structural index showing functional group transformations in solid-phase synthesis