The Complement FactsBook

Morley, Bernard J.; Walport, Mark J.

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Table of contents
  • Cover
  • Contentsv
  • Abbreviationsvii
  • Prefaceviii
  • Section I: THE INTRODUCTORY CHAPTERS1
  • Chapter 1. Introduction3
  • Chapter 2. The Complement System7
  • Section II: THE COMPLEMENT PROTEINS23
  • Part 1: Clq and the Collectins25
  • Chapter 3. C1q26
  • Chapter 4. Mannose-binding lectin31
  • Chapter 5. Bovine conglutinin36
  • Chapter 6. SP-A41
  • Chapter 7. SP-D46
  • Part 2: Serine Proteases51
  • Chapter 8. C1r52
  • Chapter 9.C1s56
  • Chapter 10. MASP-161
  • Chapter 11. MASP-265
  • Chapter 12. Factor D69
  • Chapter 13. C273
  • Chapter 14. Factor B78
  • Chapter 15. Factor I83
  • Part 3: C3 Family87
  • Chapter 16. C388
  • Chapter 17. C495
  • Chapter 18. C5104
  • Part 4: Terminal Pathway Components111
  • Chapter 19. C6112
  • Chapter 20. C7117
  • Chapter 21. C8123
  • Chapter 22. C9131
  • Part 5: Regulators of Complement Activation (RCA)135
  • Chapter 23. CRl136
  • Chapter 24. CR2146
  • Chapter 25. Decay-accelerating factor152
  • Chapter 26. Membrane cofactor protein156
  • Chapter 27. C4b-binding protein161
  • Chapter 28. Factor H168
  • Part 6: Cell Surface Receptors175
  • Chapter 29. ClqRp176
  • Chapter 30. C3a receptor180
  • Chapter 31. C5a receptor184
  • Chapter 32. CR3188
  • Chapter 33. CR4198
  • Part 7: Miscellaneous Complement Components205
  • Chapter 34. C1 inhibitor206
  • Chapter 35. Apolipoprotein J (clusterin)210
  • Chapter 36. Properdin215
  • Chapter 37. CD59219
  • Index223
Book details
  • Vendor Elsevier S & T
  • SKU 9780127333601
  • ISBN-13 9780080529554
  • Author Morley, Bernard J.; Walport, Mark J.
  • Category Medical
  • Subject Immunology

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The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies.

Key Features
* Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies
* Presents detailed structural information including cDNA and gene structure for all proteins
* Introduces complement function, simply described for each function
* Data is as up-to-date as possible, including unpublished work from many contributors
* Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, families
* Each chapter has been written by an expert in the field
* Data is as up-to-date as possible, including unpublished work from many contributors
Entries provide information on:
* Alternative nomenclature
* Physiochemical properties
* Structure and function
* Tissue distribution and regulation expression
* Protein sequence/modules
* Chromosomal location
* Genomic structure
* Database accession numbers
* Deficiency and polymorphic variants
* Key references