The Cytokine Handbook, Two-Volume Set

Thomson, Angus W.; Lotze, Michael T.

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Table of contents
  • Cover
  • The Cytokine Handbookiii
  • Copyright Pageiv
  • Contentsv
  • Preface to the First Editionxii
  • Preface to the Second Editionxv
  • Preface to the Third Editionxvii
  • Preface to the Fourth Editionxix
  • Forewordxxiii
  • Section I: Basic Cytokine Biology1
  • Chapter 1. The cytokines: an overview3
  • Chapter 2. Cytokine genetics – Polymorphisms, functional variations and disease associations19
  • Chapter 3. The phylogeny of cytokines57
  • Chapter 4. Cytokine signaling85
  • Section II: The Cytokines and Chemokines99
  • Subsection A. The Hematopoietin Family Members101
  • Chapter 5. Growth hormone103
  • Chapter 6. Prolactin115
  • Chapter 7. Erythropoietin149
  • Chapter 8. Interleukin-2167
  • Chapter 9. Interleukin-3201
  • Chapter 10. Interleukin-4227
  • Chapter 11. Interleukin-5263
  • Chapter 12. Interleukin-6 Family281
  • Chapter 13. Interleukin-7305
  • Chapter 14. Interleukin-9347
  • Chapter 15. Interleukin-11363
  • Chapter 16. Interleukin-12 Family: [IL-12, 23, 12RA and 27]383
  • Chapter 17. Interleukin-13409
  • Chapter 18. Interleukin-15 and 21431
  • Chapter 19. Interleukin-16465
  • Chapter 20. Interleukin-17 Family [IL-17, IL-25]475
  • Chapter 21. Granulocyte-macrophage colony-stimulating factor503
  • Chapter 22. Granulocyte colony-stimulating factor525
  • Subsection B. The Interferon Family Members547
  • Chapter 23. Type I interferons [IFNa,B, d, k, w, t, IL-28A (IFNk2) IL-28B (IFNk3) and IL-29 (IFNk1)]549
  • Chapter 24. Interferon-y567
  • Chapter 25. Interleukin-10603
  • Chapter 26. The IL-10 Family [Interleukins -19, -20, -22, -24 and -26]627
  • Color Plate Section Volume 1Plate 1
  • Section II: The Cytokines and Chemokines (continued)639
  • SubSection C. The Beta Trefoil Cytokines and Proinflammatory Signaling Receptors641
  • Chapter 27. Interleukin-1 Family [IL-1F1,F2]643
  • Chapter 28. Interleukin-1 receptor antagonist [IL-1F3]669
  • Chapter 29. Interleukin-18 [IL-1F4]709
  • Chapter 30. Interleukin 1 Family [F5 to F10]735
  • Chapter 31. The fibroblast growth factors747
  • Chapter 32. Hepatocyte growth factor and its receptor, MET783
  • Chapter 33. Toll-like receptors809
  • SubSection D. The TNF Family, Receptors, and Related Molecules823
  • Chapter 34. Lymphotoxins825
  • Chapter 35. Tumor necrosis factor837
  • Chapter 36. TRAIL/Apo2L861
  • Chapter 37. RANKL (Receptor activator of NFkB ligand)871
  • Chapter 38. CD95L/FasL and its receptor CD95 (APO-1/Fas)885
  • Chapter 39. HMGB-1913
  • SubSection E. The Tyrosine Kinase Receptor Signaling Molecules925
  • Chapter 40. Macrophage Colony Stimulating Factor [CSF-1]927
  • Chapter 41. EGF family ligands959
  • Chapter 42. FLT3 ligands989
  • Chapter 43. Stem cell factor1011
  • Chapter 44. Vascular endothelial growth factor1017
  • SubSection F. The Chemokines and other Cell Migration Regulating Factors1035
  • Chapter 45. Macrophage migration inhibitory factor (MIF)1037
  • Chapter 46. Interleukin-8 and other CXC chemokines1049
  • Chapter 47. CC chemokines1083
  • Chapter 48. Fractalkine1101
  • SubSection G. The TGF Beta Family Members1117
  • Chapter 49. Transforming growth factor B1119
  • Chapter 50. The activin/inhibin family1153
  • Chapter 51. Bone morphogenic proteins1179
  • Section III: Clinical Application of Cytokines and Cytokine Inhibition1187
  • Chapter 52. Autoimmunity and cytokines: pathogenesis and therapy1189
  • Chapter 53. Cytokines and cancer1213
  • Chapter 54. Interferon a: biology, pharmacology and therapy for chronic viral hepatitis1233
  • Chapter 55. Haemopoietic cytokines1255
  • Chapter 56. Antiangiogenesis and proangiogenic1279
  • Chapter 57. Cytokines and transplantation1297
  • Chapter 58. Cytokines and asthma1313
  • Chapter 59. Cytokine gene transfer1335
  • Chapter 60. Antisense therapy1349
  • Chapter 61. Assays for cytokines1375
  • Indexxxix
  • Color Plate Section Volume 2Plate 15
Book details
  • Vendor Elsevier S & T
  • SKU 9780126896633
  • ISBN-13 9780080518794
  • Author Thomson, Angus W.; Lotze, Michael T.
  • Edition 4th
  • Category Medical
  • Subject Immunology

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Ask an expert!

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses.
Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics.

Key Features
* Covers all main cytokines and chemokines
* Written by experts
* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome
* The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters
* Includes major emphasis on clinical applications
* Extensively illustrated with tables and figures