The Flaviviruses: Detection, Diagnosis and Vaccine Development: Detection, Diagnosis and Vaccine Development
Regular price
70.250 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Contentsv
- Part 1: DIAGNOSIS AND SURVEILLANCE1
- Chapter 1. Serodiagnosis of Flaviviral Infections and Vaccinations in Humans3
- I. Introduction3
- II. Serodiagnostic Tests4
- III. Specimens26
- IV. Variations in Antibody Responses and Antibody Kinetics28
- V. Flavivirus Cross-Reactivity37
- VI. Properties of Serologic Tests41
- VII. Commercial Reagents, Test Kits, and Services46
- VIII. Diagnostic Strategies47
- References48
- Chapter 2. Molecular Amplification Assays for the Detection of Flaviviruses67
- I. Introduction.67
- II. Overview of Molecular Amplification Technologies68
- III. RT-PCR–Based Assays for Flaviviruses81
- IV. NASBA Assays for Flaviviruses93
- V. Conclusion94
- References95
- Part 2: VIRUS EPIDEMIOLOGY, ECOLOGY, AND EMERGENCE101
- Chapter 3. Japanese Encephalitis103
- I. History103
- II. Clinical Description104
- III. Congenital Infection110
- IV. Animal Infections110
- V. Geographic Distribution111
- VI. Geographic Variation in Virus Strains115
- VII. Recent Changes in Geographic Range120
- VIII. Incidence and Prevalence120
- IX. Risk Factors122
- X. Ecological Factors in Disease Transmission124
- XI. Future Directions130
- References131
- Chapter 4. Epidemiology of St. Louis Encephalitis Virus139
- I. History139
- II. Clinical Description and Diagnosis142
- III. Geographical Distribution and Genetic Variation146
- IV. Incidence and Prevalence.147
- V. Risk Factors149
- VI. Transmission Cycles154
- VII. Surveillance and Control168
- VIII. Impact of West Nile Virus Introduction171
- References173
- Chapter 5. West NileVirus: Epidemiology and Ecology in North America185
- I. Introduction185
- II. History186
- III. Clinical Description187
- IV. Geographic Distribution200
- V. Molecular Epidemiology201
- VI. Epidemiology and Epizootiology202
- VII. Ecology208
- VIII. Future Directions224
- References225
- Chapter 6. Dengue Epidemiology:Virus Epidemiology, Ecology,and Emergence235
- I. Introduction235
- II. History236
- III. Clinical Description237
- IV. Pathophysiology of Dengue Hemorrhagic Fever241
- V. Geographical Distribution247
- VI. Ecology of Dengue from a Biological Perspective258
- VII. Control of DF/DHF by Management of the Mosquito Vector262
- VIII. Future Prospects265
- IX. Conclusions266
- References267
- Chapter 7. Epidemiology and Ecology of Yellow Fever Virus291
- I. History291
- II. Classification292
- III. Ecology of Yellow Fever Virus293
- IV. Epidemiology of Yellow Fever Virus298
- V. Molecular Biology of Yellow Fever Virus304
- VI. Reemergence of Yellow Fever as a Major Public Health Problem309
- References313
- Chapter 8. Tick-Borne Flaviviruses317
- I. Introduction318
- II. Tick-Borne Encephalitis Virus, a Major Human Pathogen320
- III. Other Encephalitic Tick-Transmitted Flaviviruses335
- IV. Non-Encephalitic Mammalian Tick-Borne Flaviviruses340
- V. ‘‘Hemorrhagic’’ Tick-Borne Viruses341
- VI. Seabird Tick-Transmitted Viruses347
- VII. Control of Tick-Borne Encephalitis: Prospects for Live Attenuated Tick-Borne Encephalitis Virus348
- VIII. Conclusions359
- References360
- Chapter 9. Epidemiology of Other Arthropod-Borne Flaviviruses Infecting Humans373
- I. Introduction373
- II. Other Flaviviruses of Africa374
- III. Other Flaviviruses of Europe378
- IV. Other Flaviviruses of Asia379
- V. A Flavivirus Common to North America and Asia383
- VI. Other Flaviviruses of North America384
- VII. Other Flaviviruses of South America385
- VIII. Arboviruses of Australia and New Guinea.388
- References389
- Part 3: VACCINES AND ANTIVIRAL AGENTS393
- Chapter 10. Formalin-Inactivated Whole Virus and Recombinant Subunit Flavivirus Vaccines395
- I. Introduction396
- II. Inactivated Whole Virus Vaccines397
- III. Recombinant Subunit Virus Vaccines405
- IV. Summary and Conclusions412
- References413
- Chapter 11. Empirically Derived Live-AttenuatedVaccines against Dengue and Japanese Encephalitis419
- I. Live-Attenuated Dengue Virus Vaccines420
- II. Japanese Encephalitis Virus Vaccine434
- References440
- Chapter 12. DNA Vaccines for Flaviviruses445
- I. Introduction445
- II. DNA Vaccines for Dengue Fever447
- III. DNA Vaccines for Japanese Encephalitis453
- IV. DNA Vaccines for Tick-Borne Encephalitis459
- V. DNA Vaccines for West Nile Encephalitis461
- VI. DNA Vaccines for Other Flavivirus Diseases462
- VII. Conclusion464
- References465
- Chapter 13. Chimeric Flaviviruses:Novel Vaccines against Dengue Fever, Tick-Borne Encephalitis, and469
- I. Introduction470
- II. Flavivirus Full-Length cDNA Clones and Attenuating Mutations474
- III. Chimeric Flaviviruses against Dengue Using DEN4 as the Backbone476
- IV. Chimeric Flaviviruses against TBE Using DEN4 as the Backbone484
- V. Chimeric Flaviviruses against Dengue Using Attenuated DEN2 PDK-53 as the Backbone487
- VI. Chimeric Flaviviruses Using YF 17D Vaccine Strain as the Backbone489
- VII. Summary501
- References501
- Chapter 14. Prospects for Antiviral Therapy511
- I. Introduction511
- II. Targets for Antiviral Therapy511
- III. Antiviral Therapy: Past, Present, and Future527
- IV. Animal Models539
- V. Perspectives541
- References541
- Index555
- Color Plate SectionColor Plate-1
Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.
Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research.
* Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions
* Descibes the technologies that have contributed to our current knowledge about the Flaviviruses
* Identifies the major problems faced in understanding the virus-host interactins that result in disease
* An exhaustive compendium of current and past knowledge on the Flavivirus family
Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research.
* Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions
* Descibes the technologies that have contributed to our current knowledge about the Flaviviruses
* Identifies the major problems faced in understanding the virus-host interactins that result in disease
* An exhaustive compendium of current and past knowledge on the Flavivirus family