The Genetics of Cancer: Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation
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Table of contents
- Cover
- Contentsv
- Prefacexi
- Abbreviationsxv
- Chapter 1. Introduction1
- Chapter 2. Clonal evolution of the metastatic phenotype4
- Manifestation of genetic instability5
- Chromosomal abnormalities in cancer6
- Clonal expansion of tumour cell subpopulations8
- Genetic instability and the generation of metastatic variants9
- DNA repair and repair fidelity in metastatic variants11
- Genetic recombination in the generation metastatic variants13
- Microsatellite instability in cancer progression15
- Telomerase function, genetic instability, cell proliferation and cancer metastasis20
- Chapter 3. Inefficiency of the metastatic process23
- Chapter 4 Tumour growth and metastatic potential25
- Chapter 5. Cell cycle regulation and pathogenesis of cancer27
- The regulatory role of p53 in G1-S and G2-M transition in cell cycle progression28
- Genomic organisation of the p53 gene29
- p53 abnormalities and dysfunction30
- Regulation of p53 function31
- p53, cancer progression and prognosis33
- Subcellular localisation of p53 protein39
- p53 protein as a transcription factor41
- Alternative splicing of the p53 gene transcript42
- Regulation of mdm2 by p5343
- mdm2 abnormalities in cancer43
- mdm2 and tumour progression45
- Transactivation of growth factor receptor genes by p5346
- GADD genes and their regulation by p5346
- Metastasis-associated 18A2/mtsl gene in cell cycle progression48
- Retinoblastoma susceptibility gene (rb) abnormalities in cancer50
- Cyclins, cell cycle progression and cyclins as proto-oncogenes56
- Cyclin-dependent kinase (cdk) inhibitors as tumour suppressors59
- Structural and functional features of group 1 cdk inhibitors60
- Regulation of waf1/cip1 gene expression by p5360
- Is the waf1/cip1 gene altered in cancer?63
- Response of kip1/kip2 genes to antiproliferative signals64
- kip1 gene expression in neoplasia65
- p16/ink4 putative multiple tumour suppressor gene in tumour development and progression66
- Heat shock proteins (HSPs) in development, differentiation and tumorigenesis68
- Chapter 6. Apoptosis in tumour growth and metastasis76
- The nature of apoptotic changes77
- Genetic regulation of apoptosis77
- Chapter 7. Angiogenesis in cancer86
- Induction of neovascularisation by tumours86
- Inhibitors of neovascularisation94
- Angiogenesis as a predictor of prognosis of cancer96
- Chapter 8. Cell surface glycoproteins and their receptors100
- Integrin receptors and their function100
- Vitronectin receptors101
- Laminin receptors102
- Cadherins103
- Tenascin107
- CD44 and its isoforms107
- Cell adhesion molecules (CAMs) in cancer invasion113
- Chapter 9. Proteinases and their inhibitors in cancer invasion123
- Urokinase in cancer invasion and metastasis125
- Cathepsins in cancer invasion and progression128
- Matrix metalloproteinases (MMPs) in cancer135
- Chapter 10. Oncogenes and cancer metastasis144
- The ras oncogene in tumorigenesis146
- Erb genes as predictors of cancer progression and prognosis147
- Epidermal growth factor receptors in cancer153
- Chapter 11. Developmental genes and their putative suppressor function155
- wnt genes in cell differentiation and neoplasia156
- Wilms' tumour gene wt1 in embryonic development and neoplasia163
- Chapter 12. Tumour suppressor genes171
- Progression of colorectal neoplasia172
- BRCA1 tumour suppressor (breast and ovarian carcinoma susceptibility) gene177
- DPC/BRCA2 tumour suppressor genes181
- Chapter 13. Metastasis suppressor genes183
- The putative metastasis suppressor function of the nm23 gene184
- Chapter 14. Dominant metastasis-associated genes190
- mta1 gene expression in mammary carcinoma and adenocarcinoma cell lines190
- The role of murine 18A2/mts1 homologues and other S-100 proteins in cancer progression191
- Cell differentiation and 18A2/mts1 gene expression198
- Are 18A2/mts1 and nm23 genes functionally related?200
- 18A2/mts1 and nm23 genes and cytoskeletal integrity200
- The role of cytoskeletal elements in cancer invasion202
- Growth factor receptors are associated with cytoskeletal elements203
- The p21 ras protein and the transduction of 18A2-mts1/b-mts1 proliferative signals204
- Molecular mechanisms of regulation of metastasis by 18A2/mts1 gene and its homologues205
- Epilogue211
- References215
- Index327
Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology.
Key Features
The contents include:
* Clonal evolution of the metastasis phenotype
* Cell Cycle regulation
* Apoptosis in tumour growth and metastasis
* Angiogenesis in cancer
* Cell surface glycoproteins and their receptors
* Proteinases and their inhibitors in cancer invasion
* Oncogenes and cancer metastasis
* Developmental genes
* Tumour suppressor genes
* Metastasis suppressor genes
* Dominant metastasis-associated genes
Key Features
The contents include:
* Clonal evolution of the metastasis phenotype
* Cell Cycle regulation
* Apoptosis in tumour growth and metastasis
* Angiogenesis in cancer
* Cell surface glycoproteins and their receptors
* Proteinases and their inhibitors in cancer invasion
* Oncogenes and cancer metastasis
* Developmental genes
* Tumour suppressor genes
* Metastasis suppressor genes
* Dominant metastasis-associated genes