The HLA FactsBook
Regular price
36.750 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Cover
- Contentsv
- Prefaceviii
- Abbreviationsx
- SECTION I: THE INTRODUCTORY CHAPTERS1
- Chapter 1. Introduction3
- Chapter 2. Human Leukocyte Antigens (HLA) Determine Histocompatibility in Transplantation5
- Chapter 3. The Organization of HLA Genes Within the HLA Complex7
- Chapter 4. HLA Class I Antigens and Alleles: Workshops and Nomenclature14
- Chapter 5. HLA Class II Antigens and Alleles: Workshops and Nomenclature26
- Chapter 6. HLA Typing at the DNA Level37
- Chapter 7. HLA Class I and II Molecules Present Peptide Antigens to Different Types of T Cell40
- Chapter 8. HLA Class I Molecules Control Natural Killer Cell Function46
- Chapter 9. Three-Dimensional Structures of HLA Class I Molecules52
- Chapter 10. Three-Dimensional Structures of HLA Class II Molecules57
- Chapter 11. HLA Polymorphism, Peptide-binding Motifs and T-Cell Epitopes61
- Chapter 12. Evolution and Anthropology of HLA73
- Chapter 13. HLA and Disease79
- Chapter 14. Alloreactions in Transplantation84
- SECTION II: THE HLA CLASS I AND CLASS II LOCI93
- Guide to FactsBook Tables95
- PART 1: HLA-A99
- PART 2: HLA-B151
- PART 3: HLA-C243
- PART 4: HLA-E273
- PART 5: HLA-F277
- PART 6: HLA-G279
- PART 7: HLA-DM283
- PART 8: HLA-DO287
- PART 9: HLA-DP291
- PART 10: HLA-DQ303
- PART 11: HLA-DR329
- Index391
The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity.
Key Features
* Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists
* Up-to-date, complete listing of HLA alleles
* Invaluable reference resource for immunologists, geneticists, and cell biologists
* Combines both structural and functional information, which has never been compiled in a single reference book previously
* Serological specificity of allotypes
* Identity of material sequenced including ethnic origin
* Database accession numbers
* Population distribution
* Peptide binding specificities
* T cell epitopes
* Amino acid sequences of allotypes
* Key references
Key Features
* Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists
* Up-to-date, complete listing of HLA alleles
* Invaluable reference resource for immunologists, geneticists, and cell biologists
* Combines both structural and functional information, which has never been compiled in a single reference book previously
* Serological specificity of allotypes
* Identity of material sequenced including ethnic origin
* Database accession numbers
* Population distribution
* Peptide binding specificities
* T cell epitopes
* Amino acid sequences of allotypes
* Key references